HIST1H1C and WDR12

Number of citations of the paper that reports this interaction (PMID 18258596)
25

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		HIST1H1C	WDR12
Gene Name		histone cluster 1, H1c	WD repeat domain 12
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Nuclear Euchromatin	Nucleoplasm Nucleolus Preribosome, Large Subunit Precursor PeBoW Complex
	Molecular Function	Protein Binding Chromatin DNA Binding Poly(A) RNA Binding	Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Nucleosome Assembly Nucleosome Positioning	Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Notch Signaling Pathway Cell Proliferation Ribosomal Large Subunit Biogenesis
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Cellular Senescence Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS			Coronary heart disease ( 21378990) Myocardial infarction (early onset) ( 19198609)
Protein-Protein Interactions		29 interactors: AEBP2 ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 RBM39 RBX1 VHL WDR12 WDR5 YBX1	2 interactors: HIST1H1C NOTCH1
Entrez ID		3006	55759
HPRD ID		07514	18295
Ensembl ID		ENSG00000187837
Uniprot IDs		P16403	Q53T99 Q9GZL7
PDB IDs
Enriched GO Terms of Interacting Partners?		Endodermal Cell Fate Commitment Protein Monoubiquitination Histone Monoubiquitination Positive Regulation Of Gene Expression Chromosome Organization Chromatin Modification Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone H2B Ubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Fate Commitment Involved In Formation Of Primary Germ Layer Regulation Of Nitrogen Compound Metabolic Process Chromatin Organization Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Endodermal Cell Differentiation Stem Cell Maintenance Histone Modification Negative Regulation Of Myeloid Cell Differentiation Histone Ubiquitination Positive Regulation Of Transcription, DNA-templated Regulation Of Myeloid Cell Differentiation Nitrogen Compound Metabolic Process Endoderm Formation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Stem Cell Development RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Wnt Signaling Pathway Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Endoderm Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Stem Cell Differentiation Gastrulation Regulation Of Cell Differentiation Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Cell Differentiation RNA Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter	Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation Cardiac Right Atrium Morphogenesis Mitral Valve Formation Vasculogenesis Involved In Coronary Vascular Morphogenesis Negative Regulation Of Pro-B Cell Differentiation Growth Involved In Heart Morphogenesis Atrioventricular Node Development Coronary Vein Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cell Migration Involved In Endocardial Cushion Formation Cardiac Right Ventricle Formation Negative Regulation Of Endothelial Cell Chemotaxis Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Pro-B Cell Differentiation Aortic Valve Morphogenesis Cardiac Vascular Smooth Muscle Cell Development Compartment Pattern Specification Regulation Of Extracellular Matrix Assembly Positive Regulation Of Transcription Of Notch Receptor Target Mitral Valve Morphogenesis Apoptotic Process Involved In Embryonic Digit Morphogenesis Pericardium Morphogenesis Glomerular Mesangial Cell Development Nucleosome Positioning Mitral Valve Development Coronary Artery Morphogenesis Mesangial Cell Development Cardiac Vascular Smooth Muscle Cell Differentiation Regulation Of Somitogenesis Renal Interstitial Fibroblast Development Interleukin-4 Secretion Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Notch Signaling Involved In Heart Development Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Auditory Receptor Cell Fate Commitment Pulmonary Valve Morphogenesis Arterial Endothelial Cell Differentiation Positive Regulation Of Astrocyte Differentiation Endocardial Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Endocardium Morphogenesis Vascular Smooth Muscle Cell Development Blood Vessel Endothelial Cell Differentiation Negative Regulation Of Glial Cell Proliferation Venous Blood Vessel Morphogenesis Interleukin-4 Production Coronary Vasculature Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation
Tagcloud ?		allow arf cdkn2 chromosomal comprehensive correlates downregulation enable epigenetic epigenomic grades hox hypermethylation hypomethylation inactivates individualized meningioma meningiomas modifications object p14 pertaining profiling thorough timp3 tp73 tumorigenesis upregulation wnk2	applying cholesterol cxcl12 effectors exact fam174a gfp gwas infarction internalization inversely ldl limitations loci modifies pafah1b1 powerful rarely rnai scalable sez6l surprisingly systematic tagged tbl2 trait traits unbiased unravel
Tagcloud (Difference) ?		allow arf cdkn2 chromosomal comprehensive correlates downregulation enable epigenetic epigenomic grades hox hypermethylation hypomethylation inactivates individualized meningioma meningiomas modifications object p14 pertaining profiling thorough timp3 tp73 tumorigenesis upregulation wnk2	applying cholesterol cxcl12 effectors exact fam174a gfp gwas infarction internalization inversely ldl limitations loci modifies pafah1b1 powerful rarely rnai scalable sez6l surprisingly systematic tagged tbl2 trait traits unbiased unravel
Tagcloud (Intersection) ?