HIST1H1C and NASP

Number of citations of the paper that reports this interaction (PMID 10893414)
38

Data Source:
HPRD (in vitro)

		HIST1H1C	NASP
Gene Name		histone cluster 1, H1c	nuclear autoantigenic sperm protein (histone-binding)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Nuclear Euchromatin	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Protein Complex
	Molecular Function	Protein Binding Chromatin DNA Binding Poly(A) RNA Binding	Histone Binding Hsp90 Protein Binding
	Biological Process	Nucleosome Assembly Nucleosome Positioning	Blastocyst Development DNA Replication DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Cell Cycle Cell Proliferation Protein Transport Histone Exchange
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Cellular Senescence Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		29 interactors: AEBP2 ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 RBM39 RBX1 VHL WDR12 WDR5 YBX1	14 interactors: H3F3B H3F3C HDAC6 HIST1H1A HIST1H1C HIST1H3G HIST1H3H HIST1H4A HIST2H3C LUC7L2 PTK2 TERF2 TERF2IP ULK2
Entrez ID		3006	4678
HPRD ID		07514	04423
Ensembl ID		ENSG00000187837	ENSG00000132780
Uniprot IDs		P16403	P49321 Q5T626
PDB IDs
Enriched GO Terms of Interacting Partners?		Endodermal Cell Fate Commitment Protein Monoubiquitination Histone Monoubiquitination Positive Regulation Of Gene Expression Chromosome Organization Chromatin Modification Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone H2B Ubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Fate Commitment Involved In Formation Of Primary Germ Layer Regulation Of Nitrogen Compound Metabolic Process Chromatin Organization Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Endodermal Cell Differentiation Stem Cell Maintenance Histone Modification Negative Regulation Of Myeloid Cell Differentiation Histone Ubiquitination Positive Regulation Of Transcription, DNA-templated Regulation Of Myeloid Cell Differentiation Nitrogen Compound Metabolic Process Endoderm Formation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Stem Cell Development RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Wnt Signaling Pathway Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Endoderm Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Stem Cell Differentiation Gastrulation Regulation Of Cell Differentiation Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Cell Differentiation RNA Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter	DNA Methylation On Cytosine Chromatin Silencing At RDNA Chromatin Silencing Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly DNA Methylation Protein-DNA Complex Assembly Negative Regulation Of Gene Expression, Epigenetic DNA Packaging Cellular Macromolecular Complex Assembly Chromosome Organization DNA Modification Regulation Of Gene Expression, Epigenetic Chromatin Organization Gene Silencing DNA Conformation Change Cellular Component Assembly DNA Replication-dependent Nucleosome Assembly Organelle Organization Protein Complex Assembly DNA Metabolic Process Protection From Non-homologous End Joining At Telomere Telomere Capping Methylation Blood Coagulation Hemostasis Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Telomere Maintenance Regulation Of Body Fluid Levels Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Wound Healing Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Stress Response To Wounding Regulation Of Cellular Component Organization Regulation Of Telomere Maintenance Negative Regulation Of Gene Expression RNA-dependent DNA Replication Regulation Of Gene Silencing Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening DNA Replication-independent Nucleosome Assembly Gene Expression
Tagcloud ?		allow arf cdkn2 chromosomal comprehensive correlates downregulation enable epigenetic epigenomic grades hox hypermethylation hypomethylation inactivates individualized meningioma meningiomas modifications object p14 pertaining profiling thorough timp3 tp73 tumorigenesis upregulation wnk2	1990s aerial barkley canada concentrated discharge discharges effort entrance fit fuca grid harbours inform inputs juan oily operations output pacific scenarios shore sound strait surveillance tourist trying vessel zeros
Tagcloud (Difference) ?		allow arf cdkn2 chromosomal comprehensive correlates downregulation enable epigenetic epigenomic grades hox hypermethylation hypomethylation inactivates individualized meningioma meningiomas modifications object p14 pertaining profiling thorough timp3 tp73 tumorigenesis upregulation wnk2	1990s aerial barkley canada concentrated discharge discharges effort entrance fit fuca grid harbours inform inputs juan oily operations output pacific scenarios shore sound strait surveillance tourist trying vessel zeros
Tagcloud (Intersection) ?