H1-2

Description		H1.2 linker histone, cluster member
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GO Annotations	Cellular Component	Chromatin Nucleosome Euchromatin Nucleus Chromosome
	Molecular Function	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Histone H3K27me3 Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Chromosome Condensation Negative Regulation Of DNA Recombination Facultative Heterochromatin Formation
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS
Interacting Genes		31 interacting genes: AEBP2 APP ATM CDC73 CEBPA CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 H3C1 IL7R IRAK4 ITCH KPNA7 KPNB1 LEO1 MRE11 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 SNCA VHL WDR12
Entrez ID		3006
HPRD ID		07514
Ensembl ID		ENSG00000187837
Uniprot IDs		P16403
PDB IDs		8H0V 8H0W 8KE0
Enriched GO Terms of Interacting Partners?		Nucleoplasm Endodermal Cell Fate Commitment Cell Fate Commitment Involved In Formation Of Primary Germ Layer Positive Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Cdc73/Paf1 Complex Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Chromatin Organization Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of Immune System Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Hemopoiesis Protein-containing Complex Regulation Of Myeloid Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Myeloid Cell Differentiation Transcription Elongation By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Elongation Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Stem Cell Population Maintenance Regulation Of RNA Metabolic Process Maintenance Of Cell Number Positive Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Programmed Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Enzyme Binding Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II
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