HIST1H1C and NCL

Number of citations of the paper that reports this interaction (PMID 18258596)
25

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		HIST1H1C	NCL
Gene Name		histone cluster 1, H1c	nucleolin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Nuclear Euchromatin	Nucleus Nucleoplasm Nucleolus Cell Cortex Membrane Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Chromatin DNA Binding Poly(A) RNA Binding	Nucleotide Binding RNA Binding Protein Binding Protein C-terminus Binding Telomeric DNA Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Nucleosome Assembly Nucleosome Positioning	Angiogenesis Positive Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Cellular Senescence Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder ( 23728934) Eating disorders (purging via substances) ( 23568457)
Protein-Protein Interactions		29 interactors: AEBP2 ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 RBM39 RBX1 VHL WDR12 WDR5 YBX1	48 interactors: ADAP1 ADAP2 CD3E CD3EAP CDK1 CDKN2A CSNK2A1 CSNK2A2 ERG ETS1 FMR1 GRB2 GZF1 GZMA H2AFX HIST1H1C HIST2H2AC HIST2H2BE HIST3H3 HMGA1 IL7R MDC1 MDK MDM2 MYB MYBL1 NBN NDRG1 NPM1 NR3C1 PARP1 PPARGC1A PPM1D PRKCZ PTGS1 S100A11 SREK1 SSB STAU1 TERF2 TERT TOP1 TP53 VHL XRCC6 YWHAQ ZFP36 ZNF689
Entrez ID		3006	4691
HPRD ID		07514	01245
Ensembl ID		ENSG00000187837
Uniprot IDs		P16403	B3KM80 P19338 Q9BQ02
PDB IDs			2FC8 2FC9 2KRR
Enriched GO Terms of Interacting Partners?		Endodermal Cell Fate Commitment Protein Monoubiquitination Histone Monoubiquitination Positive Regulation Of Gene Expression Chromosome Organization Chromatin Modification Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone H2B Ubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Fate Commitment Involved In Formation Of Primary Germ Layer Regulation Of Nitrogen Compound Metabolic Process Chromatin Organization Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Endodermal Cell Differentiation Stem Cell Maintenance Histone Modification Negative Regulation Of Myeloid Cell Differentiation Histone Ubiquitination Positive Regulation Of Transcription, DNA-templated Regulation Of Myeloid Cell Differentiation Nitrogen Compound Metabolic Process Endoderm Formation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Stem Cell Development RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Wnt Signaling Pathway Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Endoderm Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Stem Cell Differentiation Gastrulation Regulation Of Cell Differentiation Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Cell Differentiation RNA Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter	Chromosome Organization DNA Conformation Change Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Cell Aging Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Cycle Chromatin Organization Response To Stimulus Nucleobase-containing Compound Metabolic Process Cellular Response To Stress DNA Packaging Cellular Response To Stimulus Developmental Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Gene Expression Regulation Of Apoptotic Process Chromatin Assembly Telomere Maintenance Cellular Nitrogen Compound Metabolic Process Cell Cycle Checkpoint Regulation Of Cell Death Chromatin Assembly Or Disassembly Response To Stress Mitotic Cell Cycle Checkpoint Regulation Of Cell Proliferation DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cell Aging Negative Regulation Of Gene Expression Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Aging Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cellular Process RNA Biosynthetic Process Cellular Senescence Double-strand Break Repair Protein Complex Assembly DNA Damage Checkpoint Cell Cycle Process Regulation Of RNA Metabolic Process Mitotic Cell Cycle Process
Tagcloud ?		allow arf cdkn2 chromosomal comprehensive correlates downregulation enable epigenetic epigenomic grades hox hypermethylation hypomethylation inactivates individualized meningioma meningiomas modifications object p14 pertaining profiling thorough timp3 tp73 tumorigenesis upregulation wnk2	affinity capping corresponding deletion eif end eucaryotic fold free germ hairpin initiation interference leader loop mrna noncoding ovalbumin rabbit rate recognition restored reticulocyte secondary sequence structure systems translation wheat
Tagcloud (Difference) ?		allow arf cdkn2 chromosomal comprehensive correlates downregulation enable epigenetic epigenomic grades hox hypermethylation hypomethylation inactivates individualized meningioma meningiomas modifications object p14 pertaining profiling thorough timp3 tp73 tumorigenesis upregulation wnk2	affinity capping corresponding deletion eif end eucaryotic fold free germ hairpin initiation interference leader loop mrna noncoding ovalbumin rabbit rate recognition restored reticulocyte secondary sequence structure systems translation wheat
Tagcloud (Intersection) ?