GUCY2D and S100B

Number of citations of the paper that reports this interaction (PMID 15556616)
7

Data Source:
HPRD (in vivo)

		GUCY2D	S100B
Gene Name		guanylate cyclase 2D, membrane (retina-specific)	S100 calcium binding protein B
Image
Gene Ontology Annotations	Cellular Component	Nuclear Outer Membrane Integral Component Of Plasma Membrane Photoreceptor Disc Membrane	Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Guanylate Cyclase Activity Protein Kinase Activity Receptor Activity ATP Binding GTP Binding	Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Tau Protein Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	CGMP Biosynthetic Process Protein Phosphorylation Receptor Guanylyl Cyclase Signaling Pathway Visual Perception Phototransduction, Visible Light Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Intracellular Signal Transduction	Axonogenesis Central Nervous System Development Learning Or Memory Memory Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Neuronal Synaptic Plasticity Astrocyte Differentiation Response To Glucocorticoid Response To Methylmercury Long-term Synaptic Potentiation Cellular Response To Hypoxia Negative Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Inactivation, recovery and regulation of the phototransduction cascade Visual phototransduction The phototransduction cascade Diseases associated with visual transduction	Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Signaling by ERBB4 MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Nuclear signaling by ERBB4 Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs			Olopatadine Calcium N-Formylmethionine (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide
Diseases
GWAS			Lymphocyte counts ( 22286170)
Protein-Protein Interactions		5 interactors: GUCA1A GUCA1B GUCA2B RGS9 S100B	27 interactors: AGER AHNAK ANXA6 CACYBP CALM1 CAPZA1 DES GFAP GUCY2D IMPA1 IQGAP1 MAPT MDM2 NDRG1 PGM1 S100A1 S100A11 S100A2 S100A4 S100A6 S100P SPG21 STK38 SUGT1 TNIP1 TP53 VAV1
Entrez ID		3000	6285
HPRD ID		02550	01505
Ensembl ID		ENSG00000132518
Uniprot IDs		Q02846	P04271
PDB IDs		1AWL	1MQ1 1UWO 2H61 2PRU 3CZT 3D0Y 3D10 3HCM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Guanylate Cyclase Activity Positive Regulation Of CGMP Biosynthetic Process Positive Regulation Of CGMP Metabolic Process Regulation Of CGMP Biosynthetic Process Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of CGMP Metabolic Process Rhodopsin Mediated Signaling Pathway Positive Regulation Of Lyase Activity Regulation Of Cyclase Activity Phototransduction, Visible Light Positive Regulation Of Cyclic Nucleotide Metabolic Process Detection Of Visible Light Phototransduction Cellular Response To Light Stimulus Detection Of Light Stimulus Cellular Response To Radiation Visual Perception Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Sensory Perception Of Light Stimulus Response To Abiotic Stimulus Response To Light Stimulus Neurological System Process Response To Radiation Positive Regulation Of Catalytic Activity Detection Of Stimulus Body Fluid Secretion Sensory Perception Regulation Of Catalytic Activity Negative Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Signal Transduction G-protein Coupled Receptor Signaling Pathway Regulation Of Signaling Positive Regulation Of Metabolic Process Response To Methylmercury Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Skeletal Muscle Cell Differentiation Response To Steroid Hormone Response To External Stimulus CGMP Biosynthetic Process Negative Regulation Of Skeletal Muscle Tissue Development Regulation Of Body Fluid Levels CGMP Metabolic Process Secretion Dopamine Receptor Signaling Pathway Astrocyte Differentiation Cyclic Purine Nucleotide Metabolic Process Excretion	Regulation Of Voltage-gated Calcium Channel Activity Cellular Response To Light Stimulus Cellular Response To Radiation Cellular Response To Stimulus Response To Stimulus Signal Transduction Response To Metal Ion Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune System Process Signaling Regulation Of Cation Channel Activity Cell Communication DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Wounding Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Immune Response-regulating Signaling Pathway Response To Inorganic Substance Glycogen Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Innate Immune Response Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Polysaccharide Catabolic Process Response To Calcium Ion Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of DNA Replication Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Rhodopsin Mediated Signaling Pathway Immune Response Response To Growth Factor Response To Light Stimulus Energy Reserve Metabolic Process Defense Response Regulation Of Ion Transmembrane Transporter Activity Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Regulation Of Transmembrane Transporter Activity Nervous System Development Positive Regulation Of Cation Channel Activity Regulation Of Cellular Process Immune Response-regulating Cell Surface Receptor Signaling Pathway
Tagcloud ?		acuities acuity advancing aipl1 amaurosis cep290 childhood corrected counseling crb1 crx departments exclusion infancy lca lca5 leber multicentered ophthalmology participating pigmentosa rdh12 retinitis rp rpe65 rpgrip1 tulp1 visit visual	accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized
Tagcloud (Difference) ?		acuities acuity advancing aipl1 amaurosis cep290 childhood corrected counseling crb1 crx departments exclusion infancy lca lca5 leber multicentered ophthalmology participating pigmentosa rdh12 retinitis rp rpe65 rpgrip1 tulp1 visit visual	accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized
Tagcloud (Intersection) ?