GUCY2D and GUCA2B

Number of citations of the paper that reports this interaction (PMID 9698373)
10

Data Source:
HPRD (in vivo)

		GUCY2D	GUCA2B
Gene Name		guanylate cyclase 2D, membrane (retina-specific)	guanylate cyclase activator 2B (uroguanylin)
Image
Gene Ontology Annotations	Cellular Component	Nuclear Outer Membrane Integral Component Of Plasma Membrane Photoreceptor Disc Membrane	Extracellular Vesicular Exosome
	Molecular Function	Guanylate Cyclase Activity Protein Kinase Activity Receptor Activity ATP Binding GTP Binding	Calcium Sensitive Guanylate Cyclase Activator Activity
	Biological Process	CGMP Biosynthetic Process Protein Phosphorylation Receptor Guanylyl Cyclase Signaling Pathway Visual Perception Phototransduction, Visible Light Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Intracellular Signal Transduction	CGMP Biosynthetic Process Excretion Body Fluid Secretion Positive Regulation Of Guanylate Cyclase Activity Negative Regulation Of Blood Pressure
Pathways		Inactivation, recovery and regulation of the phototransduction cascade Visual phototransduction The phototransduction cascade Diseases associated with visual transduction
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: GUCA1A GUCA1B GUCA2B RGS9 S100B	1 interactors: GUCY2D
Entrez ID		3000	2981
HPRD ID		02550	03170
Ensembl ID		ENSG00000132518	ENSG00000044012
Uniprot IDs		Q02846	Q16661
PDB IDs		1AWL	1UYA 1UYB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Guanylate Cyclase Activity Positive Regulation Of CGMP Biosynthetic Process Positive Regulation Of CGMP Metabolic Process Regulation Of CGMP Biosynthetic Process Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of CGMP Metabolic Process Rhodopsin Mediated Signaling Pathway Positive Regulation Of Lyase Activity Regulation Of Cyclase Activity Phototransduction, Visible Light Positive Regulation Of Cyclic Nucleotide Metabolic Process Detection Of Visible Light Phototransduction Cellular Response To Light Stimulus Detection Of Light Stimulus Cellular Response To Radiation Visual Perception Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Sensory Perception Of Light Stimulus Response To Abiotic Stimulus Response To Light Stimulus Neurological System Process Response To Radiation Positive Regulation Of Catalytic Activity Detection Of Stimulus Body Fluid Secretion Sensory Perception Regulation Of Catalytic Activity Negative Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Signal Transduction G-protein Coupled Receptor Signaling Pathway Regulation Of Signaling Positive Regulation Of Metabolic Process Response To Methylmercury Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Skeletal Muscle Cell Differentiation Response To Steroid Hormone Response To External Stimulus CGMP Biosynthetic Process Negative Regulation Of Skeletal Muscle Tissue Development Regulation Of Body Fluid Levels CGMP Metabolic Process Secretion Dopamine Receptor Signaling Pathway Astrocyte Differentiation Cyclic Purine Nucleotide Metabolic Process Excretion	Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process Regulation Of Rhodopsin Mediated Signaling Pathway CGMP Metabolic Process Rhodopsin Mediated Signaling Pathway Cyclic Purine Nucleotide Metabolic Process Cyclic Nucleotide Biosynthetic Process Cyclic Nucleotide Metabolic Process Phototransduction, Visible Light Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Detection Of Light Stimulus Cellular Response To Radiation Purine Nucleotide Biosynthetic Process Visual Perception Ribose Phosphate Biosynthetic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Sensory Perception Of Light Stimulus Ribonucleotide Metabolic Process Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Response To Light Stimulus Response To Radiation
Tagcloud ?		acuities acuity advancing aipl1 amaurosis cep290 childhood corrected counseling crb1 crx departments exclusion infancy lca lca5 leber multicentered ophthalmology participating pigmentosa rdh12 retinitis rp rpe65 rpgrip1 tulp1 visit visual
Tagcloud (Difference) ?		acuities acuity advancing aipl1 amaurosis cep290 childhood corrected counseling crb1 crx departments exclusion infancy lca lca5 leber multicentered ophthalmology participating pigmentosa rdh12 retinitis rp rpe65 rpgrip1 tulp1 visit visual
Tagcloud (Intersection) ?