GUCY2D and GUCA2B

Number of citations: 0 (PubMedID 9698373)
Data Source: HPRD (in vivo)

		GUCY2D	GUCA2B
Name		guanylate cyclase 2D, retinal	guanylate cyclase activator 2B
Structure		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Photoreceptor Outer Segment Membrane Cell Projection Photoreceptor Disc Membrane	Extracellular Region Extracellular Exosome
	Molecular Function	Nucleotide Binding Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Signaling Receptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding	Protein Binding Guanylate Cyclase Activator Activity
	Biological Process	CGMP Biosynthetic Process Receptor Guanylyl Cyclase Signaling Pathway Visual Perception Cyclic Nucleotide Biosynthetic Process CGMP-mediated Signaling Regulation Of Opsin-mediated Signaling Pathway Intracellular Signal Transduction	Reduction Of Food Intake In Response To Dietary Excess Body Fluid Secretion Response To Glucose CGMP-mediated Signaling Multicellular Organism Growth Glucose Homeostasis Negative Regulation Of Blood Pressure Adipose Tissue Development Renal Sodium Ion Absorption Energy Homeostasis
Pathways		Inactivation, recovery and regulation of the phototransduction cascade	Digestion
Diseases		Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)	None
GWAS		Refractive error ( 32231278 )	Apolipoprotein A1 levels ( 32203549 )
Novel Interactors		None recorded	2 novel interactors: B4GALT2 DPCD
Interacting Genes		5 interacting genes: GUCA1A GUCA1B GUCA2B RGS9 S100B	3 interacting genes: GUCY2D UBQLN1 UBQLN2
Entrez ID		3000	2981
HPRD ID		02550	03170
Ensembl ID		ENSG00000132518	ENSG00000044012
Uniprot IDs		Q02846	Q16661
PDB IDs		Not available	1UYA 1UYB
GO Terms Enriched among Interactors		Guanylate Cyclase Regulator Activity Calcium Sensitive Guanylate Cyclase Activator Activity Cone Photoreceptor Outer Segment System Process Visual Perception Sensory Perception Of Light Stimulus Photoreceptor Disc Membrane Nervous System Process Phototransduction Response To Light Stimulus Photoreceptor Inner Segment Detection Of Light Stimulus Response To Radiation Photoreceptor Outer Segment Sensory Perception Body Fluid Secretion Positive Regulation Of Guanylate Cyclase Activity Calcium Ion Binding Detection Of Abiotic Stimulus Dark Adaptation Light Adaption Guanylate Cyclase Activator Activity Response To Anesthetic Response To Methylmercury Sympathetic Neuron Projection Extension Regulation Of Calcium Ion Export Across Plasma Membrane Positive Regulation Of CGMP-mediated Signaling Detection Of Stimulus Microtubule Cytoskeleton Negative Regulation Of Skeletal Muscle Cell Differentiation Reduction Of Food Intake In Response To Dietary Excess Regulation Of Body Fluid Levels Ciliary Basal Body Receptor Guanylyl Cyclase Signaling Pathway RAGE Receptor Binding Regulation Of CGMP-mediated Signaling Regulation Of Signal Transduction S100 Protein Binding Response To Light Intensity Developmental Growth Positive Regulation Of Myelination Regulation Of Cell Communication Positive Regulation Of Lyase Activity Positive Regulation Of Cyclase Activity Regulation Of Signaling Renal Sodium Ion Transport Renal Sodium Ion Absorption Regulation Of Skeletal Muscle Cell Differentiation Adaptive Thermogenesis G Protein-coupled Dopamine Receptor Signaling Pathway	Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Organization Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of G Protein-coupled Receptor Signaling Pathway Peptide Receptor Activity N-acetyllactosamine Synthase Activity Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity Lactose Synthase Activity Third Ventricle Development Positive Regulation Of Proteolysis Vacuole Organization Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Macroautophagy Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Response To Endoplasmic Reticulum Stress Galactosyltransferase Activity Guanylate Cyclase Activity Photoreceptor Outer Segment Membrane Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Opsin-mediated Signaling Pathway Cerebellar Purkinje Cell Layer Development Autophagy CGMP Biosynthetic Process Lateral Ventricle Development Left/right Pattern Formation Regulation Of Toll-like Receptor 3 Signaling Pathway Aggrephagy Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Receptor Internalization Regulation Of Autophagy Regulation Of Clathrin-dependent Endocytosis CGMP Metabolic Process Phosphorus-oxygen Lyase Activity Ventricular System Development Negative Regulation Of Transport Photoreceptor Disc Membrane Cyclic Nucleotide Biosynthetic Process