GUCY2D and GUCA1B

Number of citations: 0 (PubMedID 9931003)
Data Source: HPRD (in vitro)

		GUCY2D	GUCA1B
Name		guanylate cyclase 2D, retinal	guanylate cyclase activator 1B
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Photoreceptor Outer Segment Membrane Cell Projection Photoreceptor Disc Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleoplasm Plasma Membrane Cilium Microtubule Cytoskeleton Membrane Nuclear Membrane Ciliary Basal Body Cell Projection Photoreceptor Disc Membrane Cone Photoreceptor Outer Segment
	Molecular Function	Nucleotide Binding Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Signaling Receptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding	Calcium Ion Binding Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Guanylate Cyclase Regulator Activity Metal Ion Binding
	Biological Process	CGMP Biosynthetic Process Receptor Guanylyl Cyclase Signaling Pathway Visual Perception Cyclic Nucleotide Biosynthetic Process CGMP-mediated Signaling Regulation Of Opsin-mediated Signaling Pathway Intracellular Signal Transduction	Receptor Guanylyl Cyclase Signaling Pathway Cell-cell Signaling Body Fluid Secretion Visual Perception Phototransduction Regulation Of Signal Transduction
Pathways		Inactivation, recovery and regulation of the phototransduction cascade	Inactivation, recovery and regulation of the phototransduction cascade
Diseases		Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)	Retinitis pigmentosa (RP)
GWAS		Refractive error ( 32231278 )	No GWAS studies recorded
Interacting Genes		5 interacting genes: GUCA1A GUCA1B GUCA2B RGS9 S100B	3 interacting genes: GUCY2D GUCY2F OTX2
Entrez ID		3000	2979
HPRD ID		02550	03783
Ensembl ID		ENSG00000132518	ENSG00000112599
Uniprot IDs		Q02846	Q9UMX6
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Guanylate Cyclase Regulator Activity Calcium Sensitive Guanylate Cyclase Activator Activity Cone Photoreceptor Outer Segment System Process Visual Perception Sensory Perception Of Light Stimulus Photoreceptor Disc Membrane Nervous System Process Phototransduction Response To Light Stimulus Photoreceptor Inner Segment Detection Of Light Stimulus Response To Radiation Photoreceptor Outer Segment Sensory Perception Body Fluid Secretion Positive Regulation Of Guanylate Cyclase Activity Calcium Ion Binding Detection Of Abiotic Stimulus Dark Adaptation Light Adaption Guanylate Cyclase Activator Activity Response To Anesthetic Response To Methylmercury Sympathetic Neuron Projection Extension Regulation Of Calcium Ion Export Across Plasma Membrane Positive Regulation Of CGMP-mediated Signaling Detection Of Stimulus Microtubule Cytoskeleton Negative Regulation Of Skeletal Muscle Cell Differentiation Reduction Of Food Intake In Response To Dietary Excess Regulation Of Body Fluid Levels Ciliary Basal Body Receptor Guanylyl Cyclase Signaling Pathway RAGE Receptor Binding Regulation Of CGMP-mediated Signaling Regulation Of Signal Transduction S100 Protein Binding Response To Light Intensity Developmental Growth Positive Regulation Of Myelination Regulation Of Cell Communication Positive Regulation Of Lyase Activity Positive Regulation Of Cyclase Activity Regulation Of Signaling Renal Sodium Ion Transport Renal Sodium Ion Absorption Regulation Of Skeletal Muscle Cell Differentiation Adaptive Thermogenesis G Protein-coupled Dopamine Receptor Signaling Pathway	Peptide Receptor Activity Guanylate Cyclase Activity Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Opsin-mediated Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Phosphorus-oxygen Lyase Activity Photoreceptor Disc Membrane Cyclic Nucleotide Biosynthetic Process CGMP-mediated Signaling Nuclear Outer Membrane Cyclic Purine Nucleotide Metabolic Process Purine Ribonucleotide Biosynthetic Process Lyase Activity Ribose Phosphate Biosynthetic Process Regulation Of G Protein-coupled Receptor Signaling Pathway Purine Nucleotide Biosynthetic Process Visual Perception Sensory Perception Of Light Stimulus Nucleotide Biosynthetic Process Purine-containing Compound Biosynthetic Process Signaling Receptor Activity Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Positive Regulation Of Gastrulation Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Eukaryotic Initiation Factor 4E Binding Rod Photoreceptor Outer Segment Protein-containing Complex Binding GTP Binding Purine Nucleotide Metabolic Process Photoreceptor Outer Segment Membrane Primitive Streak Formation Nucleotide Metabolic Process Regulation Of Gastrulation Sensory Perception Carbohydrate Derivative Biosynthetic Process Purine-containing Compound Metabolic Process Positive Regulation Of Embryonic Development Protein Kinase Activity Detection Of Light Stimulus Involved In Visual Perception Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Midbrain Development Dopaminergic Neuron Differentiation Enzyme-linked Receptor Protein Signaling Pathway Protein Sequestering Activity