GUCY2D and GUCA1A

Number of citations: 0 (PubMedID 9931003)
Data Source: HPRD (in vitro)

		GUCY2D	GUCA1A
Name		guanylate cyclase 2D, retinal	guanylate cyclase activator 1A
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Photoreceptor Outer Segment Membrane Cell Projection Photoreceptor Disc Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Membrane Cell Projection Photoreceptor Disc Membrane Cone Photoreceptor Outer Segment
	Molecular Function	Nucleotide Binding Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Signaling Receptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding	Calcium Ion Binding Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Guanylate Cyclase Regulator Activity Metal Ion Binding
	Biological Process	CGMP Biosynthetic Process Receptor Guanylyl Cyclase Signaling Pathway Visual Perception Cyclic Nucleotide Biosynthetic Process CGMP-mediated Signaling Regulation Of Opsin-mediated Signaling Pathway Intracellular Signal Transduction	Signal Transduction Visual Perception Phototransduction Regulation Of Signal Transduction Positive Regulation Of CGMP-mediated Signaling Positive Regulation Of Guanylate Cyclase Activity Cellular Response To Calcium Ion
Pathways		Inactivation, recovery and regulation of the phototransduction cascade	Inactivation, recovery and regulation of the phototransduction cascade
Drugs		None	Myristic acid
Diseases		Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)	Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Refractive error ( 32231278 )	Femur bone mineral density x serum urate levels interaction ( 34046847 ) Spatial processing ( 31596458 )
Novel Interactors		None recorded	1 novel interactors: BCKDK
Interacting Genes		5 interacting genes: GUCA1A GUCA1B GUCA2B RGS9 S100B	9 interacting genes: AGR2 C1QTNF5 DDIT4L DEFB118 GSC2 GUCY2D HSPB1 KATNAL1 PRKAR1B
Entrez ID		3000	2978
HPRD ID		02550	02648
Ensembl ID		ENSG00000132518	ENSG00000048545
Uniprot IDs		Q02846	P43080
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Guanylate Cyclase Regulator Activity Calcium Sensitive Guanylate Cyclase Activator Activity Cone Photoreceptor Outer Segment System Process Visual Perception Sensory Perception Of Light Stimulus Photoreceptor Disc Membrane Nervous System Process Phototransduction Response To Light Stimulus Photoreceptor Inner Segment Detection Of Light Stimulus Response To Radiation Photoreceptor Outer Segment Sensory Perception Body Fluid Secretion Positive Regulation Of Guanylate Cyclase Activity Calcium Ion Binding Detection Of Abiotic Stimulus Dark Adaptation Light Adaption Guanylate Cyclase Activator Activity Response To Anesthetic Response To Methylmercury Sympathetic Neuron Projection Extension Regulation Of Calcium Ion Export Across Plasma Membrane Positive Regulation Of CGMP-mediated Signaling Detection Of Stimulus Microtubule Cytoskeleton Negative Regulation Of Skeletal Muscle Cell Differentiation Reduction Of Food Intake In Response To Dietary Excess Regulation Of Body Fluid Levels Ciliary Basal Body Receptor Guanylyl Cyclase Signaling Pathway RAGE Receptor Binding Regulation Of CGMP-mediated Signaling Regulation Of Signal Transduction S100 Protein Binding Response To Light Intensity Developmental Growth Positive Regulation Of Myelination Regulation Of Cell Communication Positive Regulation Of Lyase Activity Positive Regulation Of Cyclase Activity Regulation Of Signaling Renal Sodium Ion Transport Renal Sodium Ion Absorption Regulation Of Skeletal Muscle Cell Differentiation Adaptive Thermogenesis G Protein-coupled Dopamine Receptor Signaling Pathway	None