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GTF2H2 and ERCC8
Number of citations of the paper that reports this interaction (PMID
7664335
)
75
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
GTF2H2
ERCC8
Gene Name
general transcription factor IIH, polypeptide 2, 44kDa
excision repair cross-complementation group 8
Image
Gene Ontology Annotations
Cellular Component
Core TFIIH Complex
Nucleoplasm
Holo TFIIH Complex
Nucleotide-excision Repair Complex
Nucleus
Nucleoplasm
Nuclear Matrix
Cul4A-RING E3 Ubiquitin Ligase Complex
Protein Complex
Molecular Function
Nucleic Acid Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Kinase Activity
Protein Binding
DNA-dependent ATPase Activity
Translation Factor Activity, Nucleic Acid Binding
Zinc Ion Binding
RNA Polymerase II Carboxy-terminal Domain Kinase Activity
Protein N-terminus Binding
DNA Helicase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
DNA-dependent ATPase Activity
Protein Complex Binding
Biological Process
Nucleotide-excision Repair, DNA Damage Removal
G-protein Coupled Receptor Internalization
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Translation
Protein Phosphorylation
Response To UV
Gene Expression
Viral Process
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Viral Transcription
Protein Polyubiquitination
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Cellular Response To DNA Damage Stimulus
Response To Oxidative Stress
Response To UV
Response To X-ray
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA Repair
Protein Autoubiquitination
Pathways
RNA Polymerase II Promoter Escape
Formation of HIV-1 elongation complex containing HIV-1 Tat
Nucleotide Excision Repair
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Chain Elongation
RNA Polymerase II Transcription
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Clearance
HIV Infection
Formation of the Early Elongation Complex
Tat-mediated elongation of the HIV-1 transcript
Formation of transcription-coupled NER (TC-NER) repair complex
RNA Pol II CTD phosphorylation and interaction with CE
RNA Polymerase II Pre-transcription Events
Dual incision reaction in TC-NER
NoRC negatively regulates rRNA expression
HIV Transcription Initiation
HIV Life Cycle
RNA Pol II CTD phosphorylation and interaction with CE
RNA Polymerase II HIV Promoter Escape
HIV Transcription Elongation
Dual incision reaction in GG-NER
mRNA Capping
RNA Polymerase I Transcription
RNA Polymerase I Promoter Escape
RNA Polymerase I Transcription Termination
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Late Phase of HIV Life Cycle
Formation of RNA Pol II elongation complex
Global Genomic NER (GG-NER)
RNA Polymerase II Transcription Initiation And Promoter Clearance
Transcription-coupled NER (TC-NER)
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
Formation of incision complex in GG-NER
RNA Polymerase II Transcription Initiation
Transcription of the HIV genome
RNA Polymerase II Transcription Elongation
Nucleotide Excision Repair
Transcription-coupled NER (TC-NER)
Formation of transcription-coupled NER (TC-NER) repair complex
Dual incision reaction in TC-NER
Drugs
Diseases
GWAS
Protein-Protein Interactions
9 interactors:
AR
CDK7
ERCC2
ERCC3
ERCC8
GTF2H1
GTF2H3
GTF2H5
SRA1
8 interactors:
CBR1
CSNK2B
DDB1
ERCC6
GTF2H2
TOP1
UQCRQ
XAB2
Entrez ID
2966
1161
HPRD ID
03450
07523
Ensembl ID
ENSG00000145736
ENSG00000049167
Uniprot IDs
Q13888
B4DGZ9
Q13216
PDB IDs
1Z60
4A11
Enriched GO Terms of Interacting Partners
?
Transcription Elongation From RNA Polymerase I Promoter
Nucleotide-excision Repair
Transcription From RNA Polymerase I Promoter
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, DNA Damage Removal
Termination Of RNA Polymerase I Transcription
DNA-templated Transcription, Elongation
Transcription Initiation From RNA Polymerase I Promoter
7-methylguanosine MRNA Capping
7-methylguanosine RNA Capping
Positive Regulation Of Viral Transcription
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
Regulation Of Viral Transcription
Positive Regulation Of Viral Process
DNA-templated Transcription, Termination
Negative Regulation Of Gene Expression, Epigenetic
DNA-templated Transcription, Initiation
DNA Repair
DNA Catabolic Process
Regulation Of Viral Process
Cellular Response To DNA Damage Stimulus
MRNA Processing
Transcription From RNA Polymerase II Promoter
Regulation Of Gene Expression, Epigenetic
MRNA Metabolic Process
DNA Metabolic Process
RNA Processing
Transcription, DNA-templated
RNA Biosynthetic Process
Cellular Response To Stress
Cellular Macromolecule Catabolic Process
Aromatic Compound Catabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Viral Process
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
RNA Metabolic Process
Gene Expression
Nitrogen Compound Metabolic Process
Nucleotide-excision Repair, DNA Incision
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Transcription, DNA-templated
Nucleotide-excision Repair
Transcription-coupled Nucleotide-excision Repair
DNA Metabolic Process
Response To UV
Nucleotide-excision Repair, DNA Damage Removal
DNA Repair
Transcription Elongation From RNA Polymerase I Promoter
Transcription From RNA Polymerase I Promoter
Cellular Response To DNA Damage Stimulus
Response To Light Stimulus
Positive Regulation Of Viral Process
DNA-templated Transcription, Elongation
Response To Radiation
Viral Process
Subthalamus Development
Cellular Response To Stress
DNA Catabolic Process
Positive Regulation By Virus Of Viral Protein Levels In Host Cell
Regulation Of Viral Process
Cellular Metabolic Process
Phosphorylation
UV-damage Excision Repair
Vitamin K Metabolic Process
Positive Regulation Of Activin Receptor Signaling Pathway
Positive Regulation Of Viral Release From Host Cell
Adiponectin-activated Signaling Pathway
Activation Of JNKK Activity
Wnt Signaling Pathway
Endothelial Tube Morphogenesis
Pyramidal Neuron Development
Pons Development
Histone H2A Monoubiquitination
Pyramidal Neuron Differentiation
Embryonic Cleavage
Pyrimidine Dimer Repair
G-protein Coupled Receptor Internalization
Response To Abiotic Stimulus
Thalamus Development
Histone H2A Ubiquitination
Response To UV-B
Cyclooxygenase Pathway
Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Histone Monoubiquitination
Positive Regulation Of Viral Genome Replication
Regulation Of Activin Receptor Signaling Pathway
Prostaglandin Biosynthetic Process
Regulation Of Viral Release From Host Cell
MRNA Processing
Hypothalamus Development
Tagcloud
?
acetylation
bioflavonoid
ccna2
ccnd1
cdkn1a
chip
crna
ddx5
epigenetic
esp
estrogenic
h4
immunoprecipitation
involving
luteolin
mcf
microarray
modified
ncoa3
ncor1
nras
nrip1
pcna
plk
plk1
polr2a
proliferative
qpcr
taf9
Tagcloud (Difference)
?
acetylation
bioflavonoid
ccna2
ccnd1
cdkn1a
chip
crna
ddx5
epigenetic
esp
estrogenic
h4
immunoprecipitation
involving
luteolin
mcf
microarray
modified
ncoa3
ncor1
nras
nrip1
pcna
plk
plk1
polr2a
proliferative
qpcr
taf9
Tagcloud (Intersection)
?