GTF2H2 and SRA1

Number of citations of the paper that reports this interaction (PubMedID 20398657)
0

Data Source:
BioGRID (far western blotting)

		GTF2H2	SRA1
Description		general transcription factor IIH subunit 2	steroid receptor RNA activator 1
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GO Annotations	Cellular Component	Core TFIIH Complex Portion Of Holo TFIIH Complex Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cilium Microtubule Cytoskeleton Intercellular Bridge Ribonucleoprotein Complex
	Molecular Function	Protein Binding Zinc Ion Binding RNA Polymerase II General Transcription Initiation Factor Activity Metal Ion Binding	Steroid Receptor RNA Activator RNA Binding Transcription Coactivator Activity Protein Binding
	Biological Process	G Protein-coupled Receptor Internalization DNA Repair Nucleotide-excision Repair DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter DNA Damage Response Response To UV	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS			Refractive error ( 32231278) Schizophrenia ( 28991256) Serum immune biomarker levels ( 32066700)
Interacting Genes		11 interacting genes: AR CDK7 DNMT3L ERCC2 ERCC3 ERCC8 ERRFI1 GTF2E1 GTF2H1 GTF2H5 SRA1	30 interacting genes: ALX1 ATF1 ATF2 ATF3 ATF4 BLZF1 BTG2 CEBPA CREB1 DDIT3 DMTF1 E2F3 EGR1 EGR2 ESR1 ESR2 ESRRG ETS1 ETS2 FOS FOSB FOSL2 GATA1 GTF2B GTF2H2 GTF3C5 HAND1 NR3C1 TFAP2A UBE2Z
Entrez ID		2966	10011
HPRD ID		03450	18716
Ensembl ID		ENSG00000145736	ENSG00000213523
Uniprot IDs		Q13888	Q9HD15
PDB IDs		1Z60 5IVW 5IY6 5IY7 5IY8 5IY9 5O85 5OF4 6NMI 6O9L 6O9M 6RO4 7AD8 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	2MGX 4NBO
Enriched GO Terms of Interacting Partners?		Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Transcription Initiation At RNA Polymerase II Promoter DNA-templated Transcription Initiation Nucleotide-excision Repair Transcription By RNA Polymerase II Transcription Factor TFIID Complex DNA-templated Transcription DNA-templated Transcription Elongation Transcription-coupled Nucleotide-excision Repair DNA Repair Nucleobase-containing Compound Biosynthetic Process RNA Metabolic Process Nucleic Acid Metabolic Process Macromolecule Biosynthetic Process CAK-ERCC2 Complex Hormone-mediated Signaling Pathway DNA Metabolic Process Transcription Elongation By RNA Polymerase I DNA Damage Response Nucleobase-containing Compound Metabolic Process UV Protection Nucleoplasm Nuclear Receptor-mediated Signaling Pathway Nucleus Cellular Response To Stress Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Hair Cell Differentiation Response To UV Response To Radiation Insulin-like Growth Factor Receptor Signaling Pathway Animal Organ Development Macromolecule Metabolic Process DNA Helicase Activity Cell Death Maturation Of SSU-rRNA Programmed Cell Death Transcription Elongation By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Prostate Induction Intracellular Receptor Signaling Pathway Male Somatic Sex Determination RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity Response To Stress Regulation Of Transcription-coupled Nucleotide-excision Repair Skin Development Positive Regulation Of Mitotic Recombination Nucleotide-excision Repair Factor 3 Complex Male Meiotic Nuclear Division Nucleotide-excision Repair, Preincision Complex Assembly	DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Positive Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulator Complex RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Macromolecule Metabolic Process Skeletal Muscle Cell Differentiation Regulation Of Metabolic Process Estrogen Response Element Binding Negative Regulation Of Macromolecule Biosynthetic Process Promoter-specific Chromatin Binding Negative Regulation Of Biosynthetic Process Response To Hormone ATF4-CREB1 Transcription Factor Complex
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