GTF2H2 and GTF2H5

Number of citations of the paper that reports this interaction (PubMedID 15220921)
0

Data Source:
HPRD (in vivo)

		GTF2H2	GTF2H5
Description		general transcription factor IIH subunit 2	general transcription factor IIH subunit 5
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GO Annotations	Cellular Component	Core TFIIH Complex Portion Of Holo TFIIH Complex Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Nuclear Speck	Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Nucleolus Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding RNA Polymerase II General Transcription Initiation Factor Activity Metal Ion Binding	Protein Binding
	Biological Process	G Protein-coupled Receptor Internalization DNA Repair Nucleotide-excision Repair DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter DNA Damage Response Response To UV	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) DNA Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Assembly Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter DNA Damage Response Cellular Response To Gamma Radiation
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS			Lipoprotein (a) levels ( 26377243) Plasma anti-thyroglobulin levels ( 29678681) Systemic sclerosis ( 29293537)
Interacting Genes		11 interacting genes: AR CDK7 DNMT3L ERCC2 ERCC3 ERCC8 ERRFI1 GTF2E1 GTF2H1 GTF2H5 SRA1	8 interacting genes: ANKRD29 CDK7 ERCC3 GSC2 GTF2E1 GTF2H2 INCA1 NGRN
Entrez ID		2966	404672
HPRD ID		03450	10581
Ensembl ID		ENSG00000145736	ENSG00000272047
Uniprot IDs		Q13888	Q6ZYL4
PDB IDs		1Z60 5IVW 5IY6 5IY7 5IY8 5IY9 5O85 5OF4 6NMI 6O9L 6O9M 6RO4 7AD8 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	1YDL 2JNJ 5IVW 5IY6 5IY7 5IY8 5IY9 5OF4 6NMI 6O9L 6O9M 6RO4 7AD8 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVV 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Transcription Initiation At RNA Polymerase II Promoter DNA-templated Transcription Initiation Nucleotide-excision Repair Transcription By RNA Polymerase II Transcription Factor TFIID Complex DNA-templated Transcription DNA-templated Transcription Elongation Transcription-coupled Nucleotide-excision Repair DNA Repair Nucleobase-containing Compound Biosynthetic Process RNA Metabolic Process Nucleic Acid Metabolic Process Macromolecule Biosynthetic Process CAK-ERCC2 Complex Hormone-mediated Signaling Pathway DNA Metabolic Process Transcription Elongation By RNA Polymerase I DNA Damage Response Nucleobase-containing Compound Metabolic Process UV Protection Nucleoplasm Nuclear Receptor-mediated Signaling Pathway Nucleus Cellular Response To Stress Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Hair Cell Differentiation Response To UV Response To Radiation Insulin-like Growth Factor Receptor Signaling Pathway Animal Organ Development Macromolecule Metabolic Process DNA Helicase Activity Cell Death Maturation Of SSU-rRNA Programmed Cell Death Transcription Elongation By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Prostate Induction Intracellular Receptor Signaling Pathway Male Somatic Sex Determination RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity Response To Stress Regulation Of Transcription-coupled Nucleotide-excision Repair Skin Development Positive Regulation Of Mitotic Recombination Nucleotide-excision Repair Factor 3 Complex Male Meiotic Nuclear Division Nucleotide-excision Repair, Preincision Complex Assembly	Transcription Initiation At RNA Polymerase II Promoter Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex DNA-templated Transcription Initiation Transcription Factor TFIID Complex Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase II General Transcription Initiation Factor Activity Transcription Elongation By RNA Polymerase II DNA-templated Transcription Elongation Nucleotide-excision Repair Nucleobase-containing Compound Biosynthetic Process RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity Nucleotide-excision Repair Factor 3 Complex Transcription Factor TFIIE Complex DNA Repair Transcription Factor TFIIK Complex Core TFIIH Complex Portion Of Holo TFIIH Complex CAK-ERCC2 Complex Transcription Pausing By RNA Polymerase II RNA Metabolic Process Response To UV Nucleoplasm Macromolecule Biosynthetic Process Mitochondrial Ribosome Assembly RNA Polymerase II Promoter Clearance DNA Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity DNA Damage Response SnRNA Transcription By RNA Polymerase II DNA Topological Change Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleus Negative Regulation Of Cyclin-dependent Protein Kinase Activity UV Protection Transcription-coupled Nucleotide-excision Repair 3'-5' DNA Helicase Activity Transcription Preinitiation Complex Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity SnRNA Transcription G Protein-coupled Receptor Internalization Positive Regulation Of Mitochondrial Translation DNA Conformation Change Nucleic Acid Metabolic Process Response To Light Stimulus Regulation Of Mitochondrial Translation Ribosome Assembly
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