GTF2H2 and ERCC2

Number of citations of the paper that reports this interaction (PubMedID 9771713)
0

Data Source:
HPRD (in vitro, in vivo)

		GTF2H2	ERCC2
Description		general transcription factor IIH subunit 2	ERCC excision repair 2, TFIIH core complex helicase subunit
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GO Annotations	Cellular Component	Core TFIIH Complex Portion Of Holo TFIIH Complex Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Nuclear Speck	Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Cytoplasm Spindle Cytosol Cytoskeleton CAK-ERCC2 Complex MMXD Complex
	Molecular Function	Protein Binding Zinc Ion Binding RNA Polymerase II General Transcription Initiation Factor Activity Metal Ion Binding	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Isomerase Activity ATP Hydrolysis Activity Protein-macromolecule Adaptor Activity 5'-3' DNA Helicase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	G Protein-coupled Receptor Internalization DNA Repair Nucleotide-excision Repair DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter DNA Damage Response Response To UV	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Response To Hypoxia In Utero Embryonic Development Nucleobase-containing Compound Metabolic Process DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Apoptotic Process DNA Damage Response Response To Oxidative Stress Chromosome Segregation Determination Of Adult Lifespan Response To UV UV Protection Post-embryonic Development Spinal Cord Development Hair Cycle Process Extracellular Matrix Organization Bone Mineralization Central Nervous System Myelin Formation Multicellular Organism Growth Hair Cell Differentiation Embryonic Cleavage Ribosomal Small Subunit Biogenesis Erythrocyte Maturation Skin Development Positive Regulation Of Mitotic Recombination Insulin-like Growth Factor Receptor Signaling Pathway Embryonic Organ Development Hair Follicle Maturation Hematopoietic Stem Cell Differentiation Hematopoietic Stem Cell Proliferation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript Cytosolic iron-sulfur cluster assembly NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS			Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Lung Cancer (DNA repair capacity) ( 23108145) Sleep (1/2-day periodicity) ( 33075057)
Interacting Genes		11 interacting genes: AR CDK7 DNMT3L ERCC2 ERCC3 ERCC8 ERRFI1 GTF2E1 GTF2H1 GTF2H5 SRA1	16 interacting genes: AR CDK1 CDK7 ERCC3 ERCC5 GTF2E1 GTF2H1 GTF2H2 GTF2H2C_2 GTF2H3 HERC5 MTDH RAD51 RAD52 TP53 TRIM25
Entrez ID		2966	2068
HPRD ID		03450	00530
Ensembl ID		ENSG00000145736	ENSG00000104884
Uniprot IDs		Q13888	P18074
PDB IDs		1Z60 5IVW 5IY6 5IY7 5IY8 5IY9 5O85 5OF4 6NMI 6O9L 6O9M 6RO4 7AD8 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	5IVW 5IY6 5IY7 5IY8 5IY9 5OF4 6NMI 6O9L 6O9M 6RO4 6TUN 7AD8 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Transcription Initiation At RNA Polymerase II Promoter DNA-templated Transcription Initiation Nucleotide-excision Repair Transcription By RNA Polymerase II Transcription Factor TFIID Complex DNA-templated Transcription DNA-templated Transcription Elongation Transcription-coupled Nucleotide-excision Repair DNA Repair Nucleobase-containing Compound Biosynthetic Process RNA Metabolic Process Nucleic Acid Metabolic Process Macromolecule Biosynthetic Process CAK-ERCC2 Complex Hormone-mediated Signaling Pathway DNA Metabolic Process Transcription Elongation By RNA Polymerase I DNA Damage Response Nucleobase-containing Compound Metabolic Process UV Protection Nucleoplasm Nuclear Receptor-mediated Signaling Pathway Nucleus Cellular Response To Stress Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Hair Cell Differentiation Response To UV Response To Radiation Insulin-like Growth Factor Receptor Signaling Pathway Animal Organ Development Macromolecule Metabolic Process DNA Helicase Activity Cell Death Maturation Of SSU-rRNA Programmed Cell Death Transcription Elongation By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Prostate Induction Intracellular Receptor Signaling Pathway Male Somatic Sex Determination RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity Response To Stress Regulation Of Transcription-coupled Nucleotide-excision Repair Skin Development Positive Regulation Of Mitotic Recombination Nucleotide-excision Repair Factor 3 Complex Male Meiotic Nuclear Division Nucleotide-excision Repair, Preincision Complex Assembly	Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Nucleotide-excision Repair DNA Repair DNA-templated Transcription DNA Metabolic Process DNA Damage Response Nucleic Acid Metabolic Process Cellular Response To Stress Nucleobase-containing Compound Biosynthetic Process Nucleobase-containing Compound Metabolic Process Transcription Initiation At RNA Polymerase II Promoter Transcription By RNA Polymerase II Macromolecule Biosynthetic Process DNA-templated Transcription Initiation Transcription Factor TFIID Complex RNA Metabolic Process Macromolecule Metabolic Process Response To Stress Nucleoplasm Core TFIIH Complex Portion Of Holo TFIIH Complex Nucleus RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of Nucleobase-containing Compound Metabolic Process DNA Recombinase Assembly Response To UV Response To Oxidative Stress Regulation Of Primary Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Response To Radiation Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Transcription-coupled Nucleotide-excision Repair Chromatin Binding Transcription Preinitiation Complex Regulation Of Macromolecule Metabolic Process Response To UV-C Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Single-stranded DNA Binding Mitotic Recombination Regulation Of Metabolic Process Response To Light Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Chromosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To X-ray Cyclin-dependent Protein Serine/threonine Kinase Activity
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