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GTF2H2 and ERCC3
Number of citations of the paper that reports this interaction (PubMedID
9118947
)
35
Data Source:
HPRD
(in vivo, in vitro)
GTF2H2
ERCC3
Description
general transcription factor IIH subunit 2
ERCC excision repair 3, TFIIH core complex helicase subunit
Image
GO Annotations
Cellular Component
Core TFIIH Complex Portion Of Holo TFIIH Complex
Transcription Factor TFIIH Core Complex
Nucleus
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIH Holo Complex
Nuclear Speck
Nucleotide-excision Repair Factor 3 Complex
Transcription Factor TFIIH Core Complex
Nucleus
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIH Holo Complex
Transcription Preinitiation Complex
Molecular Function
Protein Binding
Zinc Ion Binding
RNA Polymerase II General Transcription Initiation Factor Activity
Metal Ion Binding
Nucleotide Binding
DNA Binding
DNA Helicase Activity
Damaged DNA Binding
Helicase Activity
Protein Binding
ATP Binding
Hydrolase Activity
Isomerase Activity
ATP Hydrolysis Activity
3'-5' DNA Helicase Activity
Promoter-specific Chromatin Binding
Biological Process
G Protein-coupled Receptor Internalization
DNA Repair
Nucleotide-excision Repair
DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Transcription Initiation At RNA Polymerase II Promoter
DNA Damage Response
Response To UV
DNA Topological Change
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Transcription By RNA Polymerase II
Transcription Initiation At RNA Polymerase II Promoter
Transcription Elongation By RNA Polymerase II
Apoptotic Process
DNA Damage Response
Response To Oxidative Stress
Intracellular Protein Localization
Response To UV
UV Protection
Hair Cell Differentiation
Positive Regulation Of Apoptotic Process
Embryonic Organ Development
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Interacting Genes
11 interacting genes:
AR
CDK7
DNMT3L
ERCC2
ERCC3
ERCC8
ERRFI1
GTF2E1
GTF2H1
GTF2H5
SRA1
38 interacting genes:
ADAMTSL4
AR
BCR
BLZF1
CCNC
CCNH
CDC42
CDK7
CDK8
CEP70
CEP76
E2F1
ERCC2
GOLGA2
GTF2E1
GTF2E2
GTF2H1
GTF2H2
GTF2H3
GTF2H4
GTF2H5
KPNA3
MAGED1
MCF2
MNAT1
MSANTD2
PSMC5
RAD52
ROPN1
SNW1
SRPK2
TP53
TRIM14
TRIM27
TUBG1
XIAP
XPC
ZSCAN1
Entrez ID
2966
2071
HPRD ID
03450
00593
Ensembl ID
ENSG00000145736
ENSG00000163161
Uniprot IDs
Q13888
B3KRG2
B3KTH1
P19447
PDB IDs
1Z60
5IVW
5IY6
5IY7
5IY8
5IY9
5O85
5OF4
6NMI
6O9L
6O9M
6RO4
7AD8
7EGB
7EGC
7ENA
7ENC
7LBM
7NVR
7NVW
7NVX
7NVY
7NVZ
7NW0
8BVW
8BYQ
8EBS
8EBT
8EBU
8EBV
8EBW
8EBX
8EBY
8GXQ
8GXS
8WAK
8WAL
8WAN
8WAO
8WAP
8WAQ
8WAR
8WAS
4ERN
5IVW
5IY6
5IY7
5IY8
5IY9
5OF4
6NMI
6O9L
6O9M
6RO4
7AD8
7EGB
7EGC
7ENA
7ENC
7LBM
7NVR
7NVV
7NVW
7NVX
7NVY
7NVZ
7NW0
8BVW
8BYQ
8EBS
8EBT
8EBU
8EBV
8EBW
8EBX
8EBY
8GXQ
8GXS
8WAK
8WAL
8WAN
8WAO
8WAP
8WAQ
8WAR
8WAS
Enriched GO Terms of Interacting Partners
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Transcription Factor TFIIH Core Complex
Transcription Factor TFIIH Holo Complex
Transcription Initiation At RNA Polymerase II Promoter
DNA-templated Transcription Initiation
Nucleotide-excision Repair
Transcription By RNA Polymerase II
Transcription Factor TFIID Complex
DNA-templated Transcription
DNA-templated Transcription Elongation
Transcription-coupled Nucleotide-excision Repair
DNA Repair
Nucleobase-containing Compound Biosynthetic Process
RNA Metabolic Process
Nucleic Acid Metabolic Process
Macromolecule Biosynthetic Process
CAK-ERCC2 Complex
Hormone-mediated Signaling Pathway
DNA Metabolic Process
Transcription Elongation By RNA Polymerase I
DNA Damage Response
Nucleobase-containing Compound Metabolic Process
UV Protection
Nucleoplasm
Nuclear Receptor-mediated Signaling Pathway
Nucleus
Cellular Response To Stress
Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Hair Cell Differentiation
Response To UV
Response To Radiation
Insulin-like Growth Factor Receptor Signaling Pathway
Animal Organ Development
Macromolecule Metabolic Process
DNA Helicase Activity
Cell Death
Maturation Of SSU-rRNA
Programmed Cell Death
Transcription Elongation By RNA Polymerase II
Positive Regulation Of Macromolecule Metabolic Process
Prostate Induction
Intracellular Receptor Signaling Pathway
Male Somatic Sex Determination
RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity
Response To Stress
Regulation Of Transcription-coupled Nucleotide-excision Repair
Skin Development
Positive Regulation Of Mitotic Recombination
Nucleotide-excision Repair Factor 3 Complex
Male Meiotic Nuclear Division
Nucleotide-excision Repair, Preincision Complex Assembly
Transcription Factor TFIIH Core Complex
Transcription Factor TFIIH Holo Complex
Transcription Initiation At RNA Polymerase II Promoter
Nucleotide-excision Repair
DNA-templated Transcription Initiation
Transcription Factor TFIID Complex
DNA-templated Transcription
CAK-ERCC2 Complex
RNA Polymerase II General Transcription Initiation Factor Activity
DNA Damage Response
Transcription By RNA Polymerase II
Nucleobase-containing Compound Biosynthetic Process
Transcription Factor TFIIK Complex
DNA Repair
Core TFIIH Complex Portion Of Holo TFIIH Complex
RNA Metabolic Process
Nucleoplasm
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleic Acid Metabolic Process
Nucleus
Regulation Of Cell Cycle
DNA Metabolic Process
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Cellular Response To Stress
Transcription Factor TFIIE Complex
Regulation Of Nucleobase-containing Compound Metabolic Process
Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Protein-containing Complex
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
CKM Complex
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Signal Transduction By P53 Class Mediator
Positive Regulation Of Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Transcription Elongation By RNA Polymerase I
Regulation Of Macromolecule Biosynthetic Process
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Tagcloud (Intersection)
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