SENP1 and SUMO3

Number of citations of the paper that reports this interaction (PubMedID 22878415)
26

Data Source:
BioGRID (enzymatic study)

		SENP1	SUMO3
Description		SUMO specific peptidase 1	small ubiquitin like modifier 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body
	Molecular Function	Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity SUMO-specific Endopeptidase Activity	Protein Binding Protein Tag Activity Ubiquitin-like Protein Ligase Binding
	Biological Process	Proteolysis Regulation Of Definitive Erythrocyte Differentiation Protein Sumoylation Protein Desumoylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process MRNA Destabilization Regulation Of Primary Metabolic Process Regulation Of Postsynapse Assembly	Protein Sumoylation Negative Regulation Of DNA Binding Regulation Of Protein Localization To Nucleus
Pathways		SUMO is proteolytically processed RHOF GTPase cycle	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 28898252) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Macular thickness ( 30535121) Reticulocyte count ( 32888494) Rheumatoid arthritis ( 30891314)	Delirium ( 29631748)
Interacting Genes		26 interacting genes: APP CAV3 EIF5A GCM1 HDAC1 HIPK1 HIPK2 KCNK1 MORC2 NACC1 PARP1 PIAS3 PIM1 PML RABGAP1 RANBP2 RANGAP1 RPL11 SP100 SUMO1 SUMO2 SUMO3 UBE2K USP25 USP28 USP7	62 interacting genes: ANXA7 BLM CCNE2 CDKN1A CEBPA CHAF1A COPS5 CUL3 DAXX EGLN3 FAM221A FOS HIPK1 HIPK2 HOMEZ HSF1 HSF2 JUN KALRN MAPKAPK3 MORC3 PAX6 PCGF2 PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RAD54L2 RANGAP1 RNF111 RNF8 SAE1 SENP1 SENP2 SENP5 SMN1 SNRNP70 SOX10 SOX6 SP100 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USP25 USPL1 VIM WWTR1 YAP1 ZBTB33 ZBTB39 ZCCHC12 ZMYM2 ZNF451 ZNF496
Entrez ID		29843	6612
HPRD ID		07153	03754
Ensembl ID		ENSG00000079387	ENSG00000184900
Uniprot IDs		Q9P0U3	P55854
PDB IDs		2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE 6NNQ	1U4A 2IO1 2MP2 6K5R 6NNQ 7R2E 7ZJU
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Proteolysis Protein Modification Process Post-translational Protein Modification Protein Metabolic Process Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process SUMO Transferase Activity Nucleoplasm Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process PML Body Organization Nucleus Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Stability Protein Tag Activity Protein-containing Complex Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Intracellular Transport Cellular Response To Stress Cytoplasmic Periphery Of The Nuclear Pore Complex DNA Damage Response Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nuclear Body Organization Negative Regulation Of Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Protein Localization Deubiquitinase Activity Maintenance Of Protein Location In Nucleus Ubiquitin-like Protein Ligase Binding Nuclear Pore Presynaptic Cytosol Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Postsynaptic Cytosol Negative Regulation Of Transcription By RNA Polymerase II SUMO Ligase Complex Nuclear Pore Cytoplasmic Filaments	PML Body Protein Sumoylation Nucleus Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Post-translational Protein Modification Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Protein Modification Process Regulation Of Transcription By RNA Polymerase II SUMO Transferase Activity Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process SUMO Binding SMAD Protein Signal Transduction Cellular Response To Stress SUMO Ligase Activity Positive Regulation Of Protein Sumoylation Postsynaptic Cytosol Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Transcription Corepressor Activity Positive Regulation Of Macromolecule Metabolic Process DeSUMOylase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Protein Sumoylation Protein Desumoylation Transcription Coregulator Activity Chromatin Positive Regulation Of RNA Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Presynaptic Cytosol
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