SENP1 and RABGAP1

Number of citations of the paper that reports this interaction (PMID 16608850)
61

Data Source:
BioGRID (enzymatic study)

		SENP1	RABGAP1
Gene Name		SUMO1/sentrin specific peptidase 1	RAB GTPase activating protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane	Centrosome Cytosol Microtubule Associated Complex
	Molecular Function	Endopeptidase Activity Protein Binding SUMO-specific Protease Activity	DNA Binding GTPase Activator Activity Rab GTPase Activator Activity Protein Binding Tubulin Binding Rab GTPase Binding
	Biological Process	Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Definitive Erythrocyte Differentiation Protein Sumoylation Protein Desumoylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Signaling Pathway	Cell Cycle Positive Regulation Of Rab GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		SUMO is proteolytically processed Post-translational protein modification SUMOylation Processing and activation of SUMO
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: APP CAV3 GCM1 HDAC1 HIPK2 KCNK1 PARP1 RABGAP1 RANBP2 RANGAP1 SP100 SUMO1 SUMO2 SUMO3 USP25	9 interactors: CARM1 DISC1 GABARAPL1 MAP1LC3A RAB4A RAB6A RAB6B SENP1 SENP5
Entrez ID		29843	23637
HPRD ID		07153	06575
Ensembl ID		ENSG00000079387	ENSG00000011454
Uniprot IDs		Q6N001 Q7Z3G1 Q9P0U3	Q9Y3P9
PDB IDs		2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Positive Regulation Of Metabolic Process Regulation Of DNA Binding Positive Regulation Of Cellular Metabolic Process Regulation Of Binding Positive Regulation Of Proteolysis Regulation Of Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Proteolysis PML Body Organization Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Catabolic Process Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Regulation Of Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Cellular Protein Modification Process Regulation Of Cellular Process Positive Regulation Of Cellular Protein Metabolic Process Nucleus Organization Positive Regulation Of Protein Metabolic Process Negative Regulation Of Viral Transcription Regulation Of Protein Localization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Homeostatic Process Protein Localization To Nucleus Regulation Of Protein Metabolic Process Regulation Of Protein Export From Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Peptidyl-amino Acid Modification Positive Regulation Of Gene Expression Response To Transforming Growth Factor Beta Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of DNA Binding Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Cellular Protein Metabolic Process Negative Regulation Of DNA Binding Negative Regulation Of Transcription, DNA-templated Response To Organic Substance	Rab Protein Signal Transduction Nucleophagy Protein Sumoylation Mitochondrion Degradation Ras Protein Signal Transduction Retrograde Vesicle-mediated Transport, Golgi To ER Cell Communication Organelle Disassembly Autophagic Vacuole Assembly Intra-Golgi Vesicle-mediated Transport Macroautophagy Cellular Response To Stimulus Peptidyl-amino Acid Modification Retrograde Transport, Endosome To Golgi Histone H3-R17 Methylation Vacuole Organization Histone H3-R2 Methylation Cellular Protein Localization Membrane Fusion Minus-end-directed Organelle Transport Along Microtubule Peptidyl-cysteine Methylation Cellular Response To Starvation Response To Stimulus Small GTPase Mediated Signal Transduction Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Protein Desumoylation Regulation Of Definitive Erythrocyte Differentiation Autophagy Protein Methylation Cellular Response To Nutrient Levels Response To Starvation Post-translational Protein Modification Endosomal Transport Cellular Response To Extracellular Stimulus Membrane Organization Intracellular Signal Transduction Protein Localization Early Endosome To Golgi Transport Peptidyl-lysine Modification Intracellular Protein Transport Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Golgi Vesicle Transport Antigen Processing And Presentation Signal Transduction Positive Regulation Of Proteolysis Peptidyl-arginine N-methylation Cellular Response To Nitrogen Starvation Mitochondrial Calcium Ion Homeostasis Intracellular Estrogen Receptor Signaling Pathway Signaling
Tagcloud ?		20a 5p alteration biopsies carcinogenesis ccr coli colibactin colonized consequence crc escherichia genotoxic gut harbors involve island microbiota mucosa paradigm pks producing promote senescence sumoylation suspected sustained uninfected xenograft	akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Difference) ?		20a 5p alteration biopsies carcinogenesis ccr coli colibactin colonized consequence crc escherichia genotoxic gut harbors involve island microbiota mucosa paradigm pks producing promote senescence sumoylation suspected sustained uninfected xenograft	akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Intersection) ?