SENP1 and KCNK1

Number of citations of the paper that reports this interaction (PMID 15820677)
52

Data Source:
HPRD (in vivo)

		SENP1	KCNK1
Gene Name		SUMO1/sentrin specific peptidase 1	potassium channel, two pore domain subfamily K, member 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane	Endosome Plasma Membrane Voltage-gated Potassium Channel Complex Apical Plasma Membrane Brush Border Membrane
	Molecular Function	Endopeptidase Activity Protein Binding SUMO-specific Protease Activity	Inward Rectifier Potassium Channel Activity
	Biological Process	Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Definitive Erythrocyte Differentiation Protein Sumoylation Protein Desumoylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Signaling Pathway	Potassium Ion Transport Synaptic Transmission Regulation Of Ion Transmembrane Transport Response To Nicotine Potassium Ion Transmembrane Transport
Pathways		SUMO is proteolytically processed Post-translational protein modification SUMOylation Processing and activation of SUMO	Tandem pore domain potassium channels Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Potassium Channels
Drugs			Ibutilide Quinidine Quinidine barbiturate
Diseases
GWAS			Diabetic retinopathy ( 21441570) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		15 interactors: APP CAV3 GCM1 HDAC1 HIPK2 KCNK1 PARP1 RABGAP1 RANBP2 RANGAP1 SP100 SUMO1 SUMO2 SUMO3 USP25	4 interactors: KRTAP10-3 SENP1 TCIRG1 UBE2I
Entrez ID		29843	3775
HPRD ID		07153	03447
Ensembl ID		ENSG00000079387	ENSG00000135750
Uniprot IDs		Q6N001 Q7Z3G1 Q9P0U3	O00180
PDB IDs		2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE	3UKM
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Positive Regulation Of Metabolic Process Regulation Of DNA Binding Positive Regulation Of Cellular Metabolic Process Regulation Of Binding Positive Regulation Of Proteolysis Regulation Of Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Proteolysis PML Body Organization Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Catabolic Process Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Regulation Of Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Cellular Protein Modification Process Regulation Of Cellular Process Positive Regulation Of Cellular Protein Metabolic Process Nucleus Organization Positive Regulation Of Protein Metabolic Process Negative Regulation Of Viral Transcription Regulation Of Protein Localization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Homeostatic Process Protein Localization To Nucleus Regulation Of Protein Metabolic Process Regulation Of Protein Export From Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Peptidyl-amino Acid Modification Positive Regulation Of Gene Expression Response To Transforming Growth Factor Beta Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of DNA Binding Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Cellular Protein Metabolic Process Negative Regulation Of DNA Binding Negative Regulation Of Transcription, DNA-templated Response To Organic Substance	Protein Sumoylation Positive Regulation Of SUMO Transferase Activity Post-translational Protein Modification Peptidyl-lysine Modification Protein Desumoylation Regulation Of Definitive Erythrocyte Differentiation Vacuolar Proton-transporting V-type ATPase Complex Assembly Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Vacuolar Acidification Protein Modification By Small Protein Conjugation Intracellular PH Reduction PH Reduction
Tagcloud ?		20a 5p alteration biopsies carcinogenesis ccr coli colibactin colonized consequence crc escherichia genotoxic gut harbors involve island microbiota mucosa paradigm pks producing promote senescence sumoylation suspected sustained uninfected xenograft	actinomycetemcomitans affymetrix aggregatibacter camta1 ceu characterizes checkerboard colonization correction direction fbxo38 genotyping gwa hapmap il33 imputation loci microbiome microbiota orange periodontal periodontitis replicating runx2 shifts suggestive trps1 uhrf2 vamp3
Tagcloud (Difference) ?		20a 5p alteration biopsies carcinogenesis ccr coli colibactin colonized consequence crc escherichia genotoxic gut harbors involve island mucosa paradigm pks producing promote senescence sumoylation suspected sustained uninfected xenograft	actinomycetemcomitans affymetrix aggregatibacter camta1 ceu characterizes checkerboard colonization correction direction fbxo38 genotyping gwa hapmap il33 imputation loci microbiome orange periodontal periodontitis replicating runx2 shifts suggestive trps1 uhrf2 vamp3
Tagcloud (Intersection) ?		microbiota