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SENP1
Gene Name
SUMO1/sentrin specific peptidase 1
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Focal Adhesion
Nuclear Membrane
Molecular Function
Endopeptidase Activity
Protein Binding
SUMO-specific Protease Activity
Biological Process
Proteolysis
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Definitive Erythrocyte Differentiation
Protein Sumoylation
Protein Desumoylation
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Cellular Protein Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Apoptotic Signaling Pathway
Pathways
SUMO is proteolytically processed
Post-translational protein modification
SUMOylation
Processing and activation of SUMO
Drugs
Diseases
GWAS
Protein-protein Interactions
15 interactors:
APP
CAV3
GCM1
HDAC1
HIPK2
KCNK1
PARP1
RABGAP1
RANBP2
RANGAP1
SP100
SUMO1
SUMO2
SUMO3
USP25
Entrez ID
29843
HPRD ID
07153
Ensembl ID
ENSG00000079387
Uniprot IDs
Q6N001
Q7Z3G1
Q9P0U3
PDB IDs
2CKG
2CKH
2G4D
2IY0
2IY1
2IYC
2IYD
2XPH
2XRE
Enriched GO Terms of Interacting Partners
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Protein Sumoylation
Positive Regulation Of Metabolic Process
Regulation Of DNA Binding
Positive Regulation Of Cellular Metabolic Process
Regulation Of Binding
Positive Regulation Of Proteolysis
Regulation Of Metabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Regulation Of Proteolysis
PML Body Organization
Positive Regulation Of Cellular Protein Catabolic Process
Regulation Of Protein Catabolic Process
Negative Regulation Of Protein Export From Nucleus
Positive Regulation Of Protein Catabolic Process
Regulation Of Signal Transduction
Negative Regulation Of Cellular Metabolic Process
Peptidyl-lysine Modification
Regulation Of Signaling
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
DNA Damage Response, Signal Transduction Resulting In Transcription
Cellular Protein Modification Process
Regulation Of Cellular Process
Positive Regulation Of Cellular Protein Metabolic Process
Nucleus Organization
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Viral Transcription
Regulation Of Protein Localization
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Transforming Growth Factor Beta Receptor Signaling Pathway
Homeostatic Process
Protein Localization To Nucleus
Regulation Of Protein Metabolic Process
Regulation Of Protein Export From Nucleus
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Peptidyl-amino Acid Modification
Positive Regulation Of Gene Expression
Response To Transforming Growth Factor Beta
Regulation Of Proteasomal Protein Catabolic Process
Post-translational Protein Modification
Positive Regulation Of DNA Binding
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Nucleocytoplasmic Transport
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Viral Process
Cellular Protein Metabolic Process
Negative Regulation Of DNA Binding
Negative Regulation Of Transcription, DNA-templated
Response To Organic Substance
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20a
5p
alteration
biopsies
carcinogenesis
ccr
coli
colibactin
colonized
consequence
crc
escherichia
genotoxic
gut
harbors
involve
island
microbiota
mucosa
paradigm
pks
producing
promote
senescence
sumoylation
suspected
sustained
uninfected
xenograft