SENP1 and USP25

Number of citations of the paper that reports this interaction (PMID 18538659)
53

Data Source:
BioGRID (enzymatic study)

		SENP1	USP25
Gene Name		SUMO1/sentrin specific peptidase 1	ubiquitin specific peptidase 25
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane	Nucleus Cytoplasm
	Molecular Function	Endopeptidase Activity Protein Binding SUMO-specific Protease Activity	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity SUMO Binding
	Biological Process	Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Definitive Erythrocyte Differentiation Protein Sumoylation Protein Desumoylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Signaling Pathway	Cellular Protein Modification Process Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		SUMO is proteolytically processed Post-translational protein modification SUMOylation Processing and activation of SUMO
Drugs
Diseases
GWAS			Panic disorder ( 19165232) Parkinson's disease ( 21738487)
Protein-Protein Interactions		15 interactors: APP CAV3 GCM1 HDAC1 HIPK2 KCNK1 PARP1 RABGAP1 RANBP2 RANGAP1 SP100 SUMO1 SUMO2 SUMO3 USP25	14 interactors: ACTA1 FLNC GAPDH MAGEB4 MT2A RAD23A SENP1 SKIL SUMO1 SUMO2 SYK UBC UBE2I ZNF426
Entrez ID		29843	29761
HPRD ID		07153	05296
Ensembl ID		ENSG00000079387	ENSG00000155313
Uniprot IDs		Q6N001 Q7Z3G1 Q9P0U3	Q9UHP3
PDB IDs		2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Positive Regulation Of Metabolic Process Regulation Of DNA Binding Positive Regulation Of Cellular Metabolic Process Regulation Of Binding Positive Regulation Of Proteolysis Regulation Of Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Proteolysis PML Body Organization Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Catabolic Process Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Regulation Of Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Cellular Protein Modification Process Regulation Of Cellular Process Positive Regulation Of Cellular Protein Metabolic Process Nucleus Organization Positive Regulation Of Protein Metabolic Process Negative Regulation Of Viral Transcription Regulation Of Protein Localization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Homeostatic Process Protein Localization To Nucleus Regulation Of Protein Metabolic Process Regulation Of Protein Export From Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Peptidyl-amino Acid Modification Positive Regulation Of Gene Expression Response To Transforming Growth Factor Beta Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of DNA Binding Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Cellular Protein Metabolic Process Negative Regulation Of DNA Binding Negative Regulation Of Transcription, DNA-templated Response To Organic Substance	Protein Sumoylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification Peptidyl-amino Acid Modification Peptidyl-lysine Modification Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Cytokine Regulation Of Cellular Protein Metabolic Process Innate Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Interferon-gamma Positive Regulation Of Cellular Protein Catabolic Process Response To Interferon-gamma Response To Organic Substance Viral Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Cytokine Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Muscle Fiber Development Immune Response Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Defense Response Negative Regulation Of Biosynthetic Process Immune System Process Peptidyl-cysteine S-trans-nitrosylation Positive Regulation Of SUMO Transferase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Metabolic Process JNK Cascade Skeletal Muscle Fiber Adaptation Beta Selection Positive Regulation Of Interleukin-3 Biosynthetic Process Cellular Response To Molecule Of Fungal Origin Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Gene Expression Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Tagcloud ?		20a 5p alteration biopsies carcinogenesis ccr coli colibactin colonized consequence crc escherichia genotoxic gut harbors involve island microbiota mucosa paradigm pks producing promote senescence sumoylation suspected sustained uninfected xenograft	chains cleaved cys178 cysteine deubiquitinated deubiquitinating deubiquitination dub emerged his607 histidine ifn interferon irf3 lost lysine mechanistically polyubiquitin potentiated proteases residue rig screen traf2 traf6 triggered tumornecrosis ubiquitination usps
Tagcloud (Difference) ?		20a 5p alteration biopsies carcinogenesis ccr coli colibactin colonized consequence crc escherichia genotoxic gut harbors involve island microbiota mucosa paradigm pks producing promote senescence sumoylation suspected sustained uninfected xenograft	chains cleaved cys178 cysteine deubiquitinated deubiquitinating deubiquitination dub emerged his607 histidine ifn interferon irf3 lost lysine mechanistically polyubiquitin potentiated proteases residue rig screen traf2 traf6 triggered tumornecrosis ubiquitination usps
Tagcloud (Intersection) ?