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SENP1 and SP100
Number of citations of the paper that reports this interaction (PubMedID
22878415
)
26
Data Source:
BioGRID
(enzymatic study)
SENP1
SP100
Description
SUMO specific peptidase 1
SP100 nuclear antigen
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Focal Adhesion
Nuclear Membrane
Glutamatergic Synapse
Presynaptic Cytosol
Postsynaptic Cytosol
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Nuclear Body
PML Body
Mre11 Complex
Nuclear Periphery
Molecular Function
Endopeptidase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
DeSUMOylase Activity
SUMO-specific Endopeptidase Activity
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Transcription Corepressor Activity
Protein Binding
Kinase Binding
Protein Domain Specific Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Dimerization Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Chromo Shadow Domain Binding
Biological Process
Proteolysis
Regulation Of Definitive Erythrocyte Differentiation
Protein Sumoylation
Protein Desumoylation
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Metabolic Process
MRNA Destabilization
Regulation Of Primary Metabolic Process
Regulation Of Postsynapse Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Telomere Maintenance
DNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Defense Response
Immune Response
Negative Regulation Of Endothelial Cell Migration
DNA Damage Response, Signal Transduction By P53 Class Mediator
Response To Retinoic Acid
Negative Regulation Of Viral Transcription
Response To Cytokine
Response To Type I Interferon
Response To Type II Interferon
Maintenance Of Protein Location
Regulation Of Angiogenesis
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Protein Export From Nucleus
Retinoic Acid Receptor Signaling Pathway
Regulation Of Viral Process
Type II Interferon-mediated Signaling Pathway
Type I Interferon-mediated Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Fas Signaling Pathway
Pathways
SUMO is proteolytically processed
RHOF GTPase cycle
SUMOylation of DNA damage response and repair proteins
Interferon gamma signaling
Drugs
Diseases
GWAS
Glycated hemoglobin levels (
28898252
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Macular thickness (
30535121
)
Reticulocyte count (
32888494
)
Rheumatoid arthritis (
30891314
)
Cholangiocarcinoma in primary sclerosing cholangitis (time to event) (
28779025
)
Night sleep phenotypes (
27126917
)
Post bronchodilator FEV1 (
26634245
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Interacting Genes
26 interacting genes:
APP
CAV3
EIF5A
GCM1
HDAC1
HIPK1
HIPK2
KCNK1
MORC2
NACC1
PARP1
PIAS3
PIM1
PML
RABGAP1
RANBP2
RANGAP1
RPL11
SP100
SUMO1
SUMO2
SUMO3
UBE2K
USP25
USP28
USP7
39 interacting genes:
ACTN2
AMOTL2
ARID3A
CASP8AP2
CBX1
CBX3
CBX5
CREBBP
CREM
DNMT3A
DYRK2
ETS1
GIPC2
HEMGN
HIPK2
L3MBTL3
LZTR1
MX1
MYB
NIPBL
PHC1
PML
POLR3C
RANBP2
RBM39
RTP5
SENP1
SNIP1
SUMO1
SUMO2
SUMO3
TERF1
TERF2
TERF2IP
TRAF3IP3
TRIM29
UBE2I
USPL1
ZC2HC1A
Entrez ID
29843
6672
HPRD ID
07153
06844
Ensembl ID
ENSG00000079387
ENSG00000067066
Uniprot IDs
Q9P0U3
P23497
PDB IDs
2CKG
2CKH
2G4D
2IY0
2IY1
2IYC
2IYD
2XPH
2XRE
6NNQ
1H5P
4PTB
5FB0
5FB1
5PWE
5PWF
5PWG
5PWH
5PWI
5PWJ
5PWK
5PWL
5PWM
5PWN
5PWO
5PWP
5PWQ
5PWR
5PWS
5PWT
5PWU
5PWV
5PWW
5PWX
5PWY
5PWZ
5PX0
5PX1
5PX2
5PX3
5PX4
5PX5
5PX6
5PX7
5PX8
5PX9
5PXA
5PXB
5PXC
5PXD
5PXE
5PXF
5PXG
5PXH
5PXI
5PXJ
5PXK
5PXL
5PXM
5PXN
5PXO
5PXP
5PXQ
5PXR
5PXS
5PXT
5PXU
5PXV
5PXW
5PXX
5PXY
5PXZ
5PY0
5PY1
5PY2
5PY3
5PY4
5PY5
5PY6
5PY7
5PY8
5PY9
5PYA
5PYB
5PYC
5PYD
5PYE
5PYF
5PYG
5PYH
5PYI
5PYJ
5PYK
5PYL
5PYM
5PYN
5PYO
5PYP
5PYQ
5PYR
5PYS
5PYT
5PYU
5PYV
5PYW
5PYX
5PYY
5PYZ
5PZ0
5PZ1
5PZ2
5PZ3
5PZ4
5PZ5
5PZ6
5PZ7
5PZ8
5PZ9
5PZA
5PZB
5PZC
5PZD
5PZE
5PZF
5PZG
5PZH
5PZI
5PZJ
6G5N
6G5P
Enriched GO Terms of Interacting Partners
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Protein Sumoylation
Regulation Of Ubiquitin-dependent Protein Catabolic Process
PML Body
Regulation Of Proteolysis
Protein Modification Process
Post-translational Protein Modification
Protein Metabolic Process
Macromolecule Metabolic Process
Protein Modification By Small Protein Conjugation
Ubiquitin Protein Ligase Binding
Regulation Of Protein Metabolic Process
Regulation Of Proteasomal Protein Catabolic Process
SUMO Transferase Activity
Nucleoplasm
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Catabolic Process
PML Body Organization
Nucleus
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Signal Transduction By P53 Class Mediator
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Protein Stability
Protein Tag Activity
Protein-containing Complex
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Negative Regulation Of Intracellular Transport
Cellular Response To Stress
Cytoplasmic Periphery Of The Nuclear Pore Complex
DNA Damage Response
Positive Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Nuclear Body Organization
Negative Regulation Of Proteolysis
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Protein Localization
Deubiquitinase Activity
Maintenance Of Protein Location In Nucleus
Ubiquitin-like Protein Ligase Binding
Nuclear Pore
Presynaptic Cytosol
Negative Regulation Of Macromolecule Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Postsynaptic Cytosol
Negative Regulation Of Transcription By RNA Polymerase II
SUMO Ligase Complex
Nuclear Pore Cytoplasmic Filaments
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Sumoylation
Nucleoplasm
PML Body
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Nuclear Body Organization
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
PML Body Organization
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Metabolic Process
Regulation Of Gene Expression
Nucleus
Nuclear Body
SUMO Transferase Activity
Chromosome, Telomeric Region
Shelterin Complex
Presynaptic Cytosol
Postsynaptic Cytosol
DNA Damage Response
Nuclear Telomere Cap Complex
Chromatin Binding
G-rich Strand Telomeric DNA Binding
Negative Regulation Of Telomere Maintenance
Nucleus Organization
Telomere Capping
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Protein Tag Activity
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Negative Regulation Of DNA Recombination At Telomere
Heterochromatin
Negative Regulation Of Transcription By RNA Polymerase II
Post-translational Protein Modification
Chromatin Remodeling
Chromatin Organization
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance
RNA-templated DNA Biosynthetic Process
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Tagcloud (Intersection)
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