GPX7 and SGTB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPX7	SGTB
Description		glutathione peroxidase 7	small glutamine rich tetratricopeptide repeat co-chaperone beta
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Membrane TRC Complex
	Molecular Function	Catalase Activity Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Oxidoreductase Activity	Protein Binding Hsp70 Protein Binding Identical Protein Binding Protein-folding Chaperone Binding Molecular Adaptor Activity
	Biological Process	Response To Oxidative Stress Cellular Response To Oxidative Stress Cellular Oxidant Detoxification	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homooligomerization Protein Heterooligomerization
Pathways		Detoxification of Reactive Oxygen Species
Drugs		Glutathione Glutathione Glutathione disulfide Benzoyl peroxide
Diseases
GWAS		Joint mobility (Beighton score) ( 27182965)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intralaminar thalamic nuclei volume ( 34006833) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		13 interacting genes: ASPH CEP70 CPEB2 CPNE7 ERO1A GET3 NCALD NTAQ1 SGTA SGTB TCF25 UBQLN2 UBQLN4	116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B
Entrez ID		2882	54557
HPRD ID		13606	18049
Ensembl ID		ENSG00000116157	ENSG00000197860
Uniprot IDs		Q96SL4	Q96EQ0
PDB IDs		2P31
Enriched GO Terms of Interacting Partners?		TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of ERAD Pathway Regulation Of Proteolysis Regulation Of ERAD Pathway Protein Insertion Into ER Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Establishment Of Protein Localization To Membrane Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Response To Endoplasmic Reticulum Stress Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of Cytoplasmic Translational Elongation Protein Insertion Into Membrane Peptidyl-aspartic Acid 3-dioxygenase Activity Cellular Response To Calcium Ion Protein Targeting To Membrane Negative Regulation Of G Protein-coupled Receptor Internalization Protein-N-terminal Asparagine Amidohydrolase Activity Nuclear Proteasome Complex Autophagosome GET Complex Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway RQC Complex Negative Regulation Of Autophagosome Maturation Regulation Of Protein Catabolic Process BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Proteasomal Protein Catabolic Process Activation Of Store-operated Calcium Channel Activity Cytosolic Proteasome Complex Negative Regulation Of Translational Elongation Positive Regulation Of Store-operated Calcium Channel Activity Regulation Of Sequestering Of Calcium Ion Response To Calcium Ion Regulation Of Protein-containing Complex Disassembly Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein K48-linked Ubiquitination Cellular Response To Hypoxia Thiol Oxidase Activity Negative Regulation Of ERAD Pathway Cellular Response To Decreased Oxygen Levels	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Protein Binding Collagen Trimer Endoplasmic Reticulum Chaperone Complex Endoplasmic Reticulum Extracellular Matrix Protein Folding Smooth Endoplasmic Reticulum Extracellular Matrix Structural Constituent Serine-type Endopeptidase Inhibitor Activity Sarcoplasmic Reticulum Lumen Extracellular Exosome Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Melanosome Response To Bacterium Hormone Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Oncostatin-M Receptor Activity Positive Regulation Of Transport Memory Response To Endoplasmic Reticulum Stress Defense Response To Bacterium Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Oncostatin-M-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Immune System Process Sequestering Of Calcium Ion Biomineral Tissue Development Basement Membrane Ciliary Neurotrophic Factor-mediated Signaling Pathway ERAD Pathway Growth Factor Activity Golgi Lumen Positive Regulation Of Acute Inflammatory Response Ciliary Neurotrophic Factor Receptor Binding Response To Stress Regulation Of Cell-substrate Adhesion
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?