GPX7 and CPNE7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPX7	CPNE7
Description		glutathione peroxidase 7	copine 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Nucleus Cytoplasm Plasma Membrane Membrane Synapse Extracellular Exosome
	Molecular Function	Catalase Activity Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Oxidoreductase Activity	Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding
	Biological Process	Response To Oxidative Stress Cellular Response To Oxidative Stress Cellular Oxidant Detoxification	Lipid Metabolic Process Cellular Response To Calcium Ion
Pathways		Detoxification of Reactive Oxygen Species	Glycerophospholipid biosynthesis
Drugs		Glutathione Glutathione Glutathione disulfide Benzoyl peroxide
Diseases
GWAS		Joint mobility (Beighton score) ( 27182965)	Age at first sexual intercourse ( 27089180) Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Smoking behaviour (cigarette pack-years) ( 30679032)
Interacting Genes		13 interacting genes: ASPH CEP70 CPEB2 CPNE7 ERO1A GET3 NCALD NTAQ1 SGTA SGTB TCF25 UBQLN2 UBQLN4	28 interacting genes: ADAMTSL4 CALCOCO2 CSNK2B DDIT4L DUSP21 EFHC2 GPX7 KRT75 LHX3 MEOX2 NECAB1 OTP PBX4 PICK1 PKLR REL SAXO1 TEPSIN TRIM23 TRIM27 ZFP90 ZMIZ2 ZNF18 ZNF474 ZNF572 ZNF655 ZNF774 ZRANB1
Entrez ID		2882	27132
HPRD ID		13606	05749
Ensembl ID		ENSG00000116157	ENSG00000178773
Uniprot IDs		Q96SL4	Q9UBL6
PDB IDs		2P31
Enriched GO Terms of Interacting Partners?		TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of ERAD Pathway Regulation Of Proteolysis Regulation Of ERAD Pathway Protein Insertion Into ER Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Establishment Of Protein Localization To Membrane Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Response To Endoplasmic Reticulum Stress Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of Cytoplasmic Translational Elongation Protein Insertion Into Membrane Peptidyl-aspartic Acid 3-dioxygenase Activity Cellular Response To Calcium Ion Protein Targeting To Membrane Negative Regulation Of G Protein-coupled Receptor Internalization Protein-N-terminal Asparagine Amidohydrolase Activity Nuclear Proteasome Complex Autophagosome GET Complex Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway RQC Complex Negative Regulation Of Autophagosome Maturation Regulation Of Protein Catabolic Process BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Proteasomal Protein Catabolic Process Activation Of Store-operated Calcium Channel Activity Cytosolic Proteasome Complex Negative Regulation Of Translational Elongation Positive Regulation Of Store-operated Calcium Channel Activity Regulation Of Sequestering Of Calcium Ion Response To Calcium Ion Regulation Of Protein-containing Complex Disassembly Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein K48-linked Ubiquitination Cellular Response To Hypoxia Thiol Oxidase Activity Negative Regulation Of ERAD Pathway Cellular Response To Decreased Oxygen Levels	Metal Ion Binding Zinc Ion Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Regulation Of Transcription By RNA Polymerase II
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