RHO and ARR3

Number of citations: 0 (PubMedID 9852134)
Data Source: BioGRID (pull down), HPRD (in vivo)

		RHO	ARR3
Name		rhodopsin	arrestin 3
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Photoreceptor Outer Segment Photoreceptor Inner Segment Golgi Apparatus Plasma Membrane Cell-cell Junction Membrane Golgi-associated Vesicle Membrane Photoreceptor Outer Segment Membrane Cell Projection Ciliary Membrane Photoreceptor Inner Segment Membrane Sperm Midpiece Photoreceptor Disc Membrane Rod Photoreceptor Outer Segment Sperm Head Plasma Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cell Projection Synapse
	Molecular Function	G Protein-coupled Receptor Activity 11-cis Retinal Binding Protein Binding G Protein-coupled Photoreceptor Activity Photoreceptor Activity Metal Ion Binding	G Protein-coupled Receptor Binding Opsin Binding Protein Binding Phosphoprotein Binding
	Biological Process	Microtubule Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Phototransduction, Visible Light Response To Light Stimulus Detection Of Light Stimulus Response To Light Intensity Gene Expression Absorption Of Visible Light G Protein-coupled Opsin Signaling Pathway Thermotaxis Photoreceptor Cell Maintenance Sensory Perception Of Light Stimulus Detection Of Temperature Stimulus Involved In Thermoception Retina Development In Camera-type Eye Cellular Response To Light Stimulus Podosome Assembly Rod Bipolar Cell Differentiation	G Protein-coupled Receptor Internalization Endocytosis Signal Transduction Visual Perception
Pathways		The canonical retinoid cycle in rods (twilight vision) Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G alpha (i) signalling events Opsins VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	None
Drugs		Halothane N-Acetylmethionine 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine B-nonylglucoside Phosphonothreonine B-2-Octylglucoside Hexadecanal Palmitic Acid Heptane-1,2,3-Triol Dodecyldimethylamine N-oxide (Hydroxyethyloxy)Tri(Ethyloxy)Octane e Dexfosfoserine	None
Diseases		Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO) Retinitis pigmentosa (RP) Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)	None
GWAS		Diisocyanate-induced asthma ( 25918132 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	No GWAS studies recorded
Interacting Genes		12 interacting genes: ARR3 ARRB2 CD79A DERL1 GNGT1 GRK1 GRK2 GRK5 GRK6 PPP2CA PRKCA SAG	20 interacting genes: ADRB2 AP3B1 CAPNS1 CLTC CSNK2A1 DVL2 FSHR GNMT MAP2K7 MARCHF8 OPN1MW OPN4 PLK4 PTAFR RCOR2 RHO RNASE6 SRC ZBTB43 ZNF496
Entrez ID		6010	407
HPRD ID		01584	02358
Ensembl ID		ENSG00000163914	ENSG00000120500
Uniprot IDs		P08100	P36575
PDB IDs		4ZWJ 5DGY 5W0P 6CMO	Not available
GO Terms Enriched among Interactors		G Protein-coupled Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Kinase Activity Signal Transduction G Protein-coupled Receptor Internalization Photoreceptor Outer Segment Receptor Internalization G Protein-coupled Receptor Binding Opsin Binding Phototransduction Protein Serine/threonine Kinase Activity Receptor-mediated Endocytosis G Protein-coupled Opsin Signaling Pathway G Protein-coupled Receptor Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Photoreceptor Inner Segment Detection Of Light Stimulus Negative Adaptation Of Signaling Pathway Tachykinin Receptor Signaling Pathway Protein Kinase Activity Kinase Activity Detection Of Abiotic Stimulus Photoreceptor Disc Membrane Endocytosis Nervous System Process System Process Sensory Perception Membrane Phosphoprotein Binding Positive Regulation Of Cardiac Muscle Hypertrophy Postsynaptic Signal Transduction Negative Regulation Of Relaxation Of Smooth Muscle Import Into Cell Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Muscle System Process Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Detection Of Stimulus RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Edg-2 Lysophosphatidic Acid Receptor Binding Angiotensin Receptor Binding Response To Light Stimulus RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Derlin-1-VIMP Complex Protein Phosphorylation	Photoreceptor Activity G Protein-coupled Photoreceptor Activity Thermotaxis Photoreceptor Disc Membrane G Protein-coupled Receptor Activity Detection Of Visible Light Sperm Head Plasma Membrane Absorption Of Visible Light Phototransduction Detection Of Temperature Stimulus Involved In Thermoception 11-cis Retinal Binding G Protein-coupled Receptor Signaling Pathway Response To Temperature Stimulus Detection Of Light Stimulus Positive Regulation Of MAPK Cascade Lysosome Transcytosis Regulation Of Organelle Organization Cellular Response To Light Stimulus Detection Of Temperature Stimulus Involved In Sensory Perception Uterus Development Clathrin-coated Endocytic Vesicle Detection Of Temperature Stimulus Bone Resorption Detection Of Abiotic Stimulus Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Light Stimulus Enzyme Binding Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Vacuolar Transport Regulation Of Systemic Arterial Blood Pressure Regulation Of MAPK Cascade Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of Bone Remodeling Regulation Of Bone Resorption Follicle-stimulating Hormone Receptor Activity Regulation Of Acetylcholine Metabolic Process Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Radiation Rod Bipolar Cell Differentiation RNA Polymerase III General Transcription Initiation Factor Binding Glycine N-methyltransferase Activity Positive Regulation Of ERK1 And ERK2 Cascade Visual Perception Sensory Perception Of Light Stimulus Regulation Of Macroautophagy Response To Radiation Protein Targeting To Vacuole Vasodilation Fc Receptor Signaling Pathway