RHO and SAG

Number of citations of the paper that reports this interaction (PMID 1917988)
22

Data Source:
HPRD (in vitro, in vivo)

		RHO	SAG
Gene Name		rhodopsin	S-antigen; retina and pineal gland (arrestin)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Photoreceptor Outer Segment Photoreceptor Inner Segment Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Golgi-associated Vesicle Membrane Rough Endoplasmic Reticulum Membrane Photoreceptor Outer Segment Membrane Ciliary Membrane Photoreceptor Inner Segment Membrane Photoreceptor Disc Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytosol
	Molecular Function	G-protein Coupled Receptor Activity Protein Binding Photoreceptor Activity Retinal Binding Spectrin Binding Metal Ion Binding	Opsin Binding Protein Phosphatase Inhibitor Activity Phosphoprotein Binding
	Biological Process	Retinoid Metabolic Process Protein Phosphorylation Organelle Organization G-protein Coupled Receptor Signaling Pathway Visual Perception Phototransduction, Visible Light Red, Far-red Light Phototransduction Rhodopsin Mediated Signaling Pathway Protein-chromophore Linkage Regulation Of Rhodopsin Mediated Signaling Pathway Retina Development In Camera-type Eye	Cell Surface Receptor Signaling Pathway Visual Perception Phototransduction, Visible Light Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of Catalytic Activity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Class A/1 (Rhodopsin-like receptors) Opsins VxPx cargo-targeting to cilium Assembly of the primary cilium Metabolic disorders of biological oxidation enzymes GPCR ligand binding Diseases associated with visual transduction Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade GPCR downstream signaling Visual phototransduction The phototransduction cascade The canonical retinoid cycle in rods (twilight vision) G alpha (i) signalling events	Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Visual phototransduction The phototransduction cascade Diseases associated with visual transduction
Drugs		Halothane N-Acetylmethionine 3-[Aminoethylphosphoryl]-[1,2-Di-Palmitoyl]-Sn-Glycerol Phosphonothreonine Beta-D-Mannose Alpha-D-Mannose B-2-Octylglucoside Hexadecanal Palmitic Acid Heptane-1,2,3-Triol Lauryl Dimethylamine-N-Oxide (Hydroxyethyloxy)Tri(Ethyloxy)Octane Heptyl 1-Thiohexopyranoside Phosphonoserine
Diseases
GWAS			Calcium levels ( 20705733) Crohn's disease ( 22412388)
Protein-Protein Interactions		10 interactors: ADRBK1 ARR3 DERL1 GNGT1 GRK1 GRK5 GRK6 PPP2CA PRKCA SAG	3 interactors: ADRA1B CHRM2 RHO
Entrez ID		6010	6295
HPRD ID		01584	01625
Ensembl ID		ENSG00000163914	ENSG00000130561
Uniprot IDs		P08100	A0FDN6 B7Z7L5 P10523
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Rhodopsin Mediated Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Phototransduction, Visible Light Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Light Stimulus Cellular Response To Radiation Signal Transduction Detection Of Abiotic Stimulus Signaling Cell Communication Regulation Of Signal Transduction Negative Regulation Of Signal Transduction G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Response To Light Stimulus Apoptotic Process Response To Radiation Response To Stimulus Programmed Cell Death Cell Death Death Fibroblast Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Visual Perception Sensory Perception Of Light Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Detection Of Stimulus Response To Fibroblast Growth Factor Cellular Protein Modification Process Regulation Of The Force Of Heart Contraction Inactivation Of MAPK Activity Protein Autophosphorylation Protein Phosphorylation Peptidyl-threonine Phosphorylation Photoreceptor Cell Development Activation Of Phospholipase C Activity Protein Metabolic Process Positive Regulation Of Phospholipase C Activity Nuclear Envelope Organization Negative Regulation Of Apoptotic Process	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Red, Far-red Light Phototransduction Vasoconstriction Of Artery Involved In Baroreceptor Response To Lowering Of Systemic Arterial Blood Pressure Regulation Of Heart Contraction Positive Regulation Of Glycogen Catabolic Process Negative Regulation Of Glycogen Catabolic Process Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Response To Light Stimulus Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Regulation Of The Force Of Heart Contraction By Chemical Signal Response To Radiation Regulation Of Glycogen Catabolic Process Positive Regulation Of Systemic Arterial Blood Pressure Behavioral Response To Cocaine Protein-chromophore Linkage G-protein Coupled Acetylcholine Receptor Signaling Pathway Adrenergic Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Adult Heart Development Cell Surface Receptor Signaling Pathway Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Heart Contraction Rhodopsin Mediated Signaling Pathway Chemical Homeostasis Regulation Of The Force Of Heart Contraction Vasoconstriction Positive Regulation Of Glucose Metabolic Process Response To Amphetamine Cell-cell Signaling Positive Regulation Of Blood Pressure Regulation Of Glycogen Metabolic Process Response To Morphine System Development Blood Vessel Remodeling Response To Abiotic Stimulus Response To Cocaine Response To Amine Neurological System Process Regulation Of Vasoconstriction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Visual Learning Multicellular Organismal Development Visual Behavior
Tagcloud ?		3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 seemed steps takes tc10 vdr	33p 35s abundantly anchor anchored antigenic cilia ciliary detergent devoid ethanolamine glycosylphosphatidylinositol gpi labeling moiety named paramecium partitioning phosphatidylinositol phospholipase phosphoric primaurelia sgp1 sgp2 sgp3 sgps triton unreduced weights
Tagcloud (Difference) ?		3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 seemed steps takes tc10 vdr	33p 35s abundantly anchor anchored antigenic cilia ciliary detergent devoid ethanolamine glycosylphosphatidylinositol gpi labeling moiety named paramecium partitioning phosphatidylinositol phospholipase phosphoric primaurelia sgp1 sgp2 sgp3 sgps triton unreduced weights
Tagcloud (Intersection) ?