RHO and GRK5

Number of citations: 0 (PubMedID 8144599)
Data Source: BioGRID (enzymatic study), HPRD (in vitro)

		RHO	GRK5
Name		rhodopsin	G protein-coupled receptor kinase 5
Structure
GO Annotations	Cellular Component	Golgi Membrane Photoreceptor Outer Segment Photoreceptor Inner Segment Golgi Apparatus Plasma Membrane Cell-cell Junction Membrane Golgi-associated Vesicle Membrane Photoreceptor Outer Segment Membrane Cell Projection Ciliary Membrane Photoreceptor Inner Segment Membrane Sperm Midpiece Photoreceptor Disc Membrane Rod Photoreceptor Outer Segment Sperm Head Plasma Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Speck Nuclear Membrane
	Molecular Function	G Protein-coupled Receptor Activity 11-cis Retinal Binding Protein Binding G Protein-coupled Photoreceptor Activity Photoreceptor Activity Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding Lipid Binding Kinase Activity Transferase Activity Beta-adrenergic Receptor Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Phototransduction, Visible Light Response To Light Stimulus Detection Of Light Stimulus Response To Light Intensity Gene Expression Absorption Of Visible Light G Protein-coupled Opsin Signaling Pathway Thermotaxis Photoreceptor Cell Maintenance Sensory Perception Of Light Stimulus Detection Of Temperature Stimulus Involved In Thermoception Retina Development In Camera-type Eye Cellular Response To Light Stimulus Podosome Assembly Rod Bipolar Cell Differentiation	Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Fat Cell Differentiation Protein Autophosphorylation Regulation Of Cell Cycle
Pathways		The canonical retinoid cycle in rods (twilight vision) Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G alpha (i) signalling events Opsins VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	G alpha (q) signalling events G alpha (s) signalling events
Drugs		Halothane N-Acetylmethionine 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine B-nonylglucoside Phosphonothreonine B-2-Octylglucoside Hexadecanal Palmitic Acid Heptane-1,2,3-Triol Dodecyldimethylamine N-oxide (Hydroxyethyloxy)Tri(Ethyloxy)Octane e Dexfosfoserine	None
Diseases		Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO) Retinitis pigmentosa (RP) Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)	None
GWAS		Diisocyanate-induced asthma ( 25918132 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Appendicular lean mass ( 33097823 ) Coronary artery aneurysm in Kawasaki disease ( 27171184 ) Early onset periodontitis x smoking status interaction ( 31537151 ) Height ( 28552196 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mean platelet volume ( 27863252 32888494 ) Methadone dose in opioid dependence ( 30060048 ) Neutrophil percentage of white cells ( 32888494 ) Obesity-related traits ( 23251661 ) Platelet count ( 32888494 ) Platelet distribution width ( 27863252 32888494 ) Risky sexual behaviors in alcohol dependence ( 28990359 ) Thrombin-induced platelet aggregation ( 32649856 ) Thymus and reactivation regulated chemokine levels ( 33227023 ) Type 2 diabetes ( 22961080 ) Venous thromboembolism ( 31676865 31420334 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		12 interacting genes: ARR3 ARRB2 CD79A DERL1 GNGT1 GRK1 GRK2 GRK5 GRK6 PPP2CA PRKCA SAG	19 interacting genes: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R
Entrez ID		6010	2869
HPRD ID		01584	02926
Ensembl ID		ENSG00000163914	ENSG00000198873
Uniprot IDs		P08100	P34947
PDB IDs		4ZWJ 5DGY 5W0P 6CMO	4TNB 4TND 6PJX 8UAP 8UAQ 9BRE 9BRG 9BRH 9BRI 9BRJ
GO Terms Enriched among Interactors		G Protein-coupled Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Kinase Activity Signal Transduction G Protein-coupled Receptor Internalization Photoreceptor Outer Segment Receptor Internalization G Protein-coupled Receptor Binding Opsin Binding Phototransduction Protein Serine/threonine Kinase Activity Receptor-mediated Endocytosis G Protein-coupled Opsin Signaling Pathway G Protein-coupled Receptor Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Photoreceptor Inner Segment Detection Of Light Stimulus Negative Adaptation Of Signaling Pathway Tachykinin Receptor Signaling Pathway Protein Kinase Activity Kinase Activity Detection Of Abiotic Stimulus Photoreceptor Disc Membrane Endocytosis Nervous System Process System Process Sensory Perception Membrane Phosphoprotein Binding Positive Regulation Of Cardiac Muscle Hypertrophy Postsynaptic Signal Transduction Negative Regulation Of Relaxation Of Smooth Muscle Import Into Cell Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Muscle System Process Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Detection Of Stimulus RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Edg-2 Lysophosphatidic Acid Receptor Binding Angiotensin Receptor Binding Response To Light Stimulus RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Derlin-1-VIMP Complex Protein Phosphorylation	Regulation Of Vasoconstriction Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Blood Circulation Positive Regulation Of Vasoconstriction G Protein-coupled Receptor Activity Regulation Of System Process G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Circulatory System Process Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Cytosolic Calcium Ion Concentration System Process Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure Regulation Of Smooth Muscle Contraction Regulation Of Transport Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of Muscle Contraction Modulation Of Chemical Synaptic Transmission Positive Regulation Of Blood Pressure Vasopressin Receptor Activity Regulation Of Cell Communication Cuprous Ion Binding Presynaptic Endocytosis Regulation Of Muscle System Process Smooth Muscle Contraction Regulation Of Signaling Regulation Of Small Molecule Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Biological Quality Plasma Membrane Regulation Of Secretion Vesicle-mediated Transport In Synapse Endocytosis Sperm Ejaculation Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Endosome Synaptic Vesicle Endocytosis Signal Transduction Membrane Chemical Synaptic Transmission Sperm Midpiece Positive Regulation Of Small Molecule Metabolic Process Regulation Of Secretion By Cell Trans-synaptic Signaling Regulation Of Metal Ion Transport Synaptic Signaling Axon Terminus Aggressive Behavior