GPR17 and GNA13

Number of citations of the paper that reports this interaction (PubMedID 9092554)
0

Data Source:
HPRD (in vivo)

		GPR17	GNA13
Description		G protein-coupled receptor 17	G protein subunit alpha 13
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Exosome Postsynapse
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Receptor Serine/threonine Kinase Binding	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Signal Transduction G Protein-coupled Receptor Signaling Pathway Oligodendrocyte Differentiation Chemokine-mediated Signaling Pathway	Angiogenesis Branching Involved In Blood Vessel Morphogenesis In Utero Embryonic Development Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Blood Pressure Regulation Of Cell Shape Regulation Of Fibroblast Migration Cell Differentiation Platelet Activation Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynapse Assembly Rho-activating G Protein-coupled Receptor Signaling Pathway
Pathways		Leukotriene receptors G alpha (q) signalling events P2Y receptors G alpha (i) signalling events	NRAGE signals death through JNK G alpha (12/13) signalling events Thromboxane signalling through TP receptor Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) CDC42 GTPase cycle RAC1 GTPase cycle
Drugs		Uridine diphosphate glucose Uridine-5'-Diphosphate Galactose-uridine-5'-diphosphate
Diseases
GWAS		Proportion of activated microglia (inferior temporal cortex) ( 30679421)	Brain morphology (MOSTest) ( 32665545) Periventricular white matter hyperintensities ( 32517579) White matter microstructure (global fractional anisotropy) ( 24736177)
Interacting Genes		2 interacting genes: GNA13 GPR37	31 interacting genes: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR
Entrez ID		2840	10672
HPRD ID		04351	05100
Ensembl ID		ENSG00000144230	ENSG00000120063
Uniprot IDs		G4XH68 Q13304	Q14344
PDB IDs		7Y89	7SF7 7SF8 7T6B 7YDH 8H8J 8KGG 8ZX4 8ZX5 9GE2 9GE3 9IY8 9IZH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nitric-oxide Synthase Activity Alpha-galactosidase Activity Prosaposin Receptor Activity D5 Dopamine Receptor Binding Glycosylceramide Catabolic Process Regulation Of Nitric-oxide Synthase Activity Glycoside Catabolic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Dopamine Metabolic Process Locomotion Involved In Locomotory Behavior Rho-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Oxidoreductase Activity Dopamine Biosynthetic Process Glycosylceramide Metabolic Process Glycosphingolipid Catabolic Process Glycolipid Catabolic Process Ceramide Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Oxidoreductase Activity Regulation Of Dopamine Metabolic Process Catecholamine Biosynthetic Process Neuropeptide Receptor Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Neuropeptide Binding Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Peptide Binding G Protein-coupled Receptor Signaling Pathway Amine Biosynthetic Process Biogenic Amine Biosynthetic Process Dopamine Metabolic Process Branching Involved In Blood Vessel Morphogenesis Heterotrimeric G-protein Complex Sphingolipid Catabolic Process G Protein-coupled Peptide Receptor Activity Membrane Lipid Catabolic Process Dendrite Development Catecholamine Metabolic Process Regulation Of Fibroblast Migration Regulation Of Postsynapse Assembly Hsp70 Protein Binding Glycosphingolipid Metabolic Process Brush Border Membrane Oligosaccharide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Biogenic Amine Metabolic Process Heat Shock Protein Binding Rho Protein Signal Transduction Platelet Activation	G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Membrane G Protein-coupled Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Oxygen-containing Compound Intracellular Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette G Protein-coupled Receptor Binding Sphingosine-1-phosphate Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Vasculature Development Peptidyl-serine Phosphorylation Positive Regulation Of Signal Transduction Modulation Of Chemical Synaptic Transmission Guanyl-nucleotide Exchange Factor Activity Sphingosine-1-phosphate Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Sphingolipid Mediated Signaling Pathway Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Lipid Cell Motility Regulation Of Multicellular Organismal Process Regulation Of Blood Pressure Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Catenin Complex Cell Surface Receptor Signaling Pathway Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity G-protein Alpha-subunit Binding Cell Migration Lamellipodium Regulation Of Protein Localization Regulation Of Vasculature Development Regulation Of Developmental Process Cellular Response To Indole-3-methanol
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