CXCR3 and PF4

Number of citations: 52 (PubMedID 12782716)
Data Source: BioGRID (pull down), HPRD (in vitro)

		CXCR3	PF4
Name		C-X-C motif chemokine receptor 3	platelet factor 4
Structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Platelet Alpha Granule Lumen
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding C-X-C Chemokine Binding Signaling Receptor Activity	Cytokine Activity Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding Receptor Ligand Activity CXCR3 Chemokine Receptor Binding
	Biological Process	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Regulation Of Leukocyte Migration Apoptotic Process Chemotaxis Inflammatory Response Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation T Cell Chemotaxis Negative Regulation Of Angiogenesis Calcium-mediated Signaling Regulation Of Cell Adhesion Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Chemotaxis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Chemotaxis Chemokine-mediated Signaling Pathway Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis	Monocyte Chemotaxis Chemotaxis Defense Response Inflammatory Response Immune Response Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Platelet Activation Negative Regulation Of Blood Coagulation Neutrophil Chemotaxis Leukocyte Chemotaxis Killing Of Cells Of Another Organism Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Defense Response To Protozoan Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Macrophage Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Platelet degranulation Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall Chemokine receptors bind chemokines G alpha (i) signalling events RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs		None	Drotrecogin alfa Heparin
GWAS		No GWAS studies recorded	Inflammatory bowel disease ( 23128233 ) Metabolite levels ( 22916037 ) Serum metabolite levels ( 31636271 ) Serum metabolite levels (CMS) ( 31636271 )
Interacting Genes		9 interacting genes: C2CD2L CLDN19 CXCL10 CXCL11 CXCL13 CXCL9 FATE1 PF4 TMEM14A	29 interacting genes: CCL11 CCL13 CCL2 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL6 CXCL8 CXCL9 CXCR3 FGF2 LDLR PROC SDC2 SNCA SRGN THBD VCAN XCL1 XCL2
Entrez ID		2833	5196
HPRD ID		02936	01426
Ensembl ID		ENSG00000186810	ENSG00000163737
Uniprot IDs		P49682	P02776
PDB IDs		8HNK 8HNL 8HNM 8HNN 8K2W 8K2X 8XXY 8XXZ 8XYI 8XYK 8Y0H 8Y0N	1DN3 1F9Q 1F9R 1F9S 1PFM 1PFN 1RHP 4R9W 4R9Y 4RAU
GO Terms Enriched among Interactors		CXCR3 Chemokine Receptor Binding Chemokine Activity CXCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Killing Of Cells Of Another Organism Leukocyte Chemotaxis Antimicrobial Humoral Response Neutrophil Chemotaxis Cell Killing Neutrophil Migration Cell Chemotaxis Cytokine Activity Granulocyte Chemotaxis Leukocyte Migration Chemokine-mediated Signaling Pathway Granulocyte Migration Humoral Immune Response Mononuclear Cell Migration Lymphocyte Chemotaxis Chemotaxis Myeloid Leukocyte Migration Locomotion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heparin Binding Cytokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Lymphocyte Migration Inflammatory Response Positive Regulation Of Calcium Ion Transmembrane Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Positive Regulation Of Calcium Ion Transport Defense Response To Symbiont Defense Response To Other Organism G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cation Transmembrane Transport Regulation Of T Cell Chemotaxis Positive Regulation Of Monoatomic Ion Transmembrane Transport T Cell Chemotaxis Regulation Of Sequestering Of Calcium Ion Regulation Of Transport Cell Migration Regulation Of Calcium Ion Transmembrane Transport Regulation Of Myoblast Fusion Cellular Response To Lipid Regulation Of Lymphocyte Chemotaxis	Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Chemotaxis Chemotaxis Antimicrobial Humoral Response Cytokine Activity Locomotion Leukocyte Chemotaxis Chemokine-mediated Signaling Pathway Humoral Immune Response Leukocyte Migration Cell Migration Extracellular Space Cell Motility Granulocyte Chemotaxis Killing Of Cells Of Another Organism Granulocyte Migration Myeloid Leukocyte Migration Cell Killing Inflammatory Response CCR Chemokine Receptor Binding Defense Response To Symbiont Extracellular Region Defense Response To Other Organism Response To External Biotic Stimulus Mononuclear Cell Migration Cytokine-mediated Signaling Pathway Immune Response Positive Regulation Of Locomotion Response To Other Organism Positive Regulation Of Chemotaxis Defense Response Immune System Process Regulation Of Leukocyte Migration Eosinophil Chemotaxis Positive Regulation Of Cell Migration Eosinophil Migration Chemokine Receptor Binding Regulation Of Locomotion Positive Regulation Of Cell Motility G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Chemotaxis CXCR Chemokine Receptor Binding Lymphocyte Migration Regulation Of Cell Motility Positive Regulation Of Calcium Ion Transport T Cell Migration Response To Stress Lymphocyte Chemotaxis