CXCR3 and CLDN19

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CXCR3	CLDN19
Description		C-X-C motif chemokine receptor 3	claudin 19
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Nucleus Cytoplasm Plasma Membrane Bicellular Tight Junction Membrane Basolateral Plasma Membrane Cell Junction Paranodal Junction Schmidt-Lanterman Incisure Apical Junction Complex Perinuclear Region Of Cytoplasm Tight Junction Anchoring Junction Mesaxon
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding C-X-C Chemokine Binding Signaling Receptor Activity	Structural Molecule Activity Protein Binding Identical Protein Binding Cell-cell Adhesion Mediator Activity Paracellular Tight Junction Channel Activity
	Biological Process	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Regulation Of Leukocyte Migration Apoptotic Process Chemotaxis Inflammatory Response Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation T Cell Chemotaxis Negative Regulation Of Angiogenesis Calcium-mediated Signaling Regulation Of Cell Adhesion Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Chemotaxis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Chemotaxis Chemokine-mediated Signaling Pathway Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis	Retinal Pigment Epithelium Development Cell Adhesion Visual Perception Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Neuronal Action Potential Propagation Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cell Junction Assembly Apical Junction Assembly Renal Absorption Bicellular Tight Junction Assembly Tight Junction Organization Regulation Of Transepithelial Transport Paracellular Transport
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Tight junction interactions
Drugs
Diseases
GWAS
Interacting Genes		9 interacting genes: C2CD2L CLDN19 CXCL10 CXCL11 CXCL13 CXCL9 FATE1 PF4 TMEM14A	63 interacting genes: AQP6 AQP9 BCL2L13 BIK BSCL2 BTN2A1 CD200R1 CD53 CD74 CLEC14A CLEC2D CLRN1 CREB3 CXCR3 CYSRT1 ERGIC3 FAM209A FCGR1A FCGRT FKBP7 FNDC9 GGT7 GJA8 GORAB GPR161 GPX8 HSD17B13 ICAM3 IFNGR2 IL3RA KEL KIR2DL3 KRT31 KRT34 LAPTM5 LRRC25 LRRC4C MFF MS4A14 MS4A4A MUC1 PDZK1IP1 PKD2L1 PLEKHB2 PVR SAR1A SCARB2 SGPL1 SLAMF6 SLC10A1 SLC35H1 SPACA1 SRPK2 STOM STOML3 SUSD3 SYNE4 TM4SF18 TMEM106C TMEM248 TMEM52B TMEM80 TNFSF14
Entrez ID		2833	149461
HPRD ID		02936	10834
Ensembl ID		ENSG00000186810	ENSG00000164007
Uniprot IDs		P49682	Q8N6F1
PDB IDs		8HNK 8HNL 8HNM 8HNN 8K2W 8K2X 8XXY 8XXZ 8XYI 8XYK 8Y0H 8Y0N
Enriched GO Terms of Interacting Partners?		CXCR3 Chemokine Receptor Binding Chemokine Activity CXCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Killing Of Cells Of Another Organism Leukocyte Chemotaxis Antimicrobial Humoral Response Neutrophil Chemotaxis Cell Killing Neutrophil Migration Cell Chemotaxis Cytokine Activity Granulocyte Chemotaxis Leukocyte Migration Chemokine-mediated Signaling Pathway Granulocyte Migration Humoral Immune Response Mononuclear Cell Migration Lymphocyte Chemotaxis Chemotaxis Myeloid Leukocyte Migration Locomotion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heparin Binding Cytokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Lymphocyte Migration Inflammatory Response Positive Regulation Of Calcium Ion Transmembrane Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Positive Regulation Of Calcium Ion Transport Defense Response To Symbiont Defense Response To Other Organism G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cation Transmembrane Transport Regulation Of T Cell Chemotaxis Positive Regulation Of Monoatomic Ion Transmembrane Transport T Cell Chemotaxis Regulation Of Sequestering Of Calcium Ion Regulation Of Transport Cell Migration Regulation Of Calcium Ion Transmembrane Transport Regulation Of Myoblast Fusion Cellular Response To Lipid Regulation Of Lymphocyte Chemotaxis	Membrane Protein Binding External Side Of Plasma Membrane Plasma Membrane
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