CXCR3 and CXCL11

Number of citations of the paper that reports this interaction (PubMedID 9625760)
59

Data Source:
HPRD (in vitro, in vivo)

		CXCR3	CXCL11
Description		C-X-C motif chemokine receptor 3	C-X-C motif chemokine ligand 11
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Extracellular Region Extracellular Space
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding C-X-C Chemokine Binding Signaling Receptor Activity	Cytokine Activity Protein Binding Chemokine Activity Heparin Binding CXCR3 Chemokine Receptor Binding
	Biological Process	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Regulation Of Leukocyte Migration Apoptotic Process Chemotaxis Inflammatory Response Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation T Cell Chemotaxis Negative Regulation Of Angiogenesis Calcium-mediated Signaling Regulation Of Cell Adhesion Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Chemotaxis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Chemotaxis Chemokine-mediated Signaling Pathway Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis	Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling T Cell Chemotaxis Killing Of Cells Of Another Organism Regulation Of Cell Population Proliferation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Hippocampal volume ( 29274321) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		9 interacting genes: C2CD2L CLDN19 CXCL10 CXCL11 CXCL13 CXCL9 FATE1 PF4 TMEM14A	25 interacting genes: CCL1 CCL11 CCL13 CCL20 CCL21 CCL24 CCL25 CCL26 CCL5 CCL8 CCR3 CXCL10 CXCL12 CXCL14 CXCL2 CXCL9 CXCR3 DPP4 LRRK2 MTUS2 PF4 PF4V1 PPBP SMARCB1 XCL1
Entrez ID		2833	6373
HPRD ID		02936	05329
Ensembl ID		ENSG00000186810	ENSG00000169248
Uniprot IDs		P49682	O14625
PDB IDs		8HNK 8HNL 8HNM 8HNN 8K2W 8K2X 8XXY 8XXZ 8XYI 8XYK 8Y0H 8Y0N	1RJT 8HNK
Enriched GO Terms of Interacting Partners?		CXCR3 Chemokine Receptor Binding Chemokine Activity CXCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Killing Of Cells Of Another Organism Leukocyte Chemotaxis Antimicrobial Humoral Response Neutrophil Chemotaxis Cell Killing Neutrophil Migration Cell Chemotaxis Cytokine Activity Granulocyte Chemotaxis Leukocyte Migration Chemokine-mediated Signaling Pathway Granulocyte Migration Humoral Immune Response Mononuclear Cell Migration Lymphocyte Chemotaxis Chemotaxis Myeloid Leukocyte Migration Locomotion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heparin Binding Cytokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Lymphocyte Migration Inflammatory Response Positive Regulation Of Calcium Ion Transmembrane Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Positive Regulation Of Calcium Ion Transport Defense Response To Symbiont Defense Response To Other Organism G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cation Transmembrane Transport Regulation Of T Cell Chemotaxis Positive Regulation Of Monoatomic Ion Transmembrane Transport T Cell Chemotaxis Regulation Of Sequestering Of Calcium Ion Regulation Of Transport Cell Migration Regulation Of Calcium Ion Transmembrane Transport Regulation Of Myoblast Fusion Cellular Response To Lipid Regulation Of Lymphocyte Chemotaxis	Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemotaxis Locomotion Antimicrobial Humoral Response Cytokine Activity Leukocyte Chemotaxis Humoral Immune Response Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Leukocyte Migration Granulocyte Migration Cell Migration Killing Of Cells Of Another Organism Myeloid Leukocyte Migration Cell Motility Inflammatory Response Cell Killing CCR Chemokine Receptor Binding Defense Response Eosinophil Chemotaxis Defense Response To Symbiont Eosinophil Migration Defense Response To Other Organism Immune Response Cytokine-mediated Signaling Pathway Immune System Process Response To Other Organism Extracellular Space Response To External Biotic Stimulus Regulation Of Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Response To Stress CXCR Chemokine Receptor Binding Positive Regulation Of Locomotion Extracellular Region Mononuclear Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Migration Positive Regulation Of Leukocyte Migration Regulation Of Cell Motility Chemokine Receptor Binding Regulation Of Chemotaxis Positive Regulation Of T Cell Migration Positive Regulation Of Chemotaxis Positive Regulation Of Lymphocyte Migration Cell Surface Receptor Signaling Pathway
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