CXCR3 and C2CD2L

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CXCR3	C2CD2L
Description		C-X-C motif chemokine receptor 3	C2CD2 like
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Cortical Endoplasmic Reticulum Cytoplasmic Side Of Apical Plasma Membrane Endoplasmic Reticulum-plasma Membrane Contact Site
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding C-X-C Chemokine Binding Signaling Receptor Activity	Protein Binding Lipid Binding Phosphatidylinositol Transfer Activity Phosphatidylinositol Binding Insulin Binding
	Biological Process	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Regulation Of Leukocyte Migration Apoptotic Process Chemotaxis Inflammatory Response Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation T Cell Chemotaxis Negative Regulation Of Angiogenesis Calcium-mediated Signaling Regulation Of Cell Adhesion Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Chemotaxis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Chemotaxis Chemokine-mediated Signaling Pathway Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis	Lipid Transport Phospholipid Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intermembrane Lipid Transfer
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS			Glycated hemoglobin levels ( 34059833) Heel bone mineral density ( 30598549)
Interacting Genes		9 interacting genes: C2CD2L CLDN19 CXCL10 CXCL11 CXCL13 CXCL9 FATE1 PF4 TMEM14A	31 interacting genes: AQP6 ARL13B CD79A CHODL CISD2 CLRN1 CPEB2 CXCR3 EBP EPB41 FCER1G GJA8 GJB1 HIBADH IL3RA MUC1 OPRM1 PDZK1IP1 REEP2 REEP4 SDCBP SLC10A6 SLC18A1 SLC61A1 TMEM14B TMEM179B TMEM31 TMEM86B TMEM9 TMPRSS2 TMX2
Entrez ID		2833	9854
HPRD ID		02936	15533
Ensembl ID		ENSG00000186810	ENSG00000172375
Uniprot IDs		P49682	O14523
PDB IDs		8HNK 8HNL 8HNM 8HNN 8K2W 8K2X 8XXY 8XXZ 8XYI 8XYK 8Y0H 8Y0N	5TOD
Enriched GO Terms of Interacting Partners?		CXCR3 Chemokine Receptor Binding Chemokine Activity CXCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Killing Of Cells Of Another Organism Leukocyte Chemotaxis Antimicrobial Humoral Response Neutrophil Chemotaxis Cell Killing Neutrophil Migration Cell Chemotaxis Cytokine Activity Granulocyte Chemotaxis Leukocyte Migration Chemokine-mediated Signaling Pathway Granulocyte Migration Humoral Immune Response Mononuclear Cell Migration Lymphocyte Chemotaxis Chemotaxis Myeloid Leukocyte Migration Locomotion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heparin Binding Cytokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Lymphocyte Migration Inflammatory Response Positive Regulation Of Calcium Ion Transmembrane Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Positive Regulation Of Calcium Ion Transport Defense Response To Symbiont Defense Response To Other Organism G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cation Transmembrane Transport Regulation Of T Cell Chemotaxis Positive Regulation Of Monoatomic Ion Transmembrane Transport T Cell Chemotaxis Regulation Of Sequestering Of Calcium Ion Regulation Of Transport Cell Migration Regulation Of Calcium Ion Transmembrane Transport Regulation Of Myoblast Fusion Cellular Response To Lipid Regulation Of Lymphocyte Chemotaxis	Membrane Endoplasmic Reticulum Membrane Interleukin-3-mediated Signaling Pathway
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