SFN and TSC2

Number of citations of the paper that reports this interaction (PubMedID 36931259)
0

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vivo, in vitro)

		SFN	TSC2
Description		stratifin	TSC complex subunit 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Extracellular Exosome	Nucleus Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Cytosol Postsynaptic Density Membrane TSC1-TSC2 Complex Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Identical Protein Binding Cadherin Binding Phosphoserine Residue Binding Phosphoprotein Binding Protein Sequestering Activity	GTPase Activator Activity Protein Binding Phosphatase Binding Small GTPase Binding Protein Homodimerization Activity Hsp90 Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Release Of Cytochrome C From Mitochondria Keratinocyte Development Negative Regulation Of Protein Kinase Activity Protein Export From Nucleus Signal Transduction Intracellular Protein Localization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Epidermal Cell Division Negative Regulation Of Keratinocyte Proliferation Regulation Of Cell-cell Adhesion Keratinocyte Differentiation Positive Regulation Of Cell Growth Keratinization Regulation Of Protein Localization Defense Response To Bacterium Skin Development Keratinocyte Proliferation Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Innate Immune Response Positive Regulation Of Protein Export From Nucleus Cytolysis In Another Organism Regulation Of Cell Cycle Establishment Of Skin Barrier Stem Cell Proliferation CAMP/PKA Signal Transduction Non-canonical Inflammasome Complex Assembly Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization Negative Regulation Of Stem Cell Proliferation	Neural Tube Closure Cytoplasmic Translation Protein Import Into Nucleus Endocytosis Heart Development Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Vesicle-mediated Transport Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling TORC1 Signaling Anoikis Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Positive Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Mitophagy Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways	Macroautophagy Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer TBC/RABGAPs
Drugs
Diseases			Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS		Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Eosinophil percentage of white cells ( 32888494) Neutrophil percentage of granulocytes ( 27863252)	Major depressive disorder ( 29317602) Obesity-related traits ( 23251661) White blood cell count ( 32888494)
Interacting Genes		62 interacting genes: ABL1 ARAF BAD BAX BCR BRAF CCAR1 CCDC102B CCDC125 CCNH CDC25B CDK1 CHST1 COP1 DUXAP9 EEF1A1 EGFR EIF2S1 EIF4B ENTREP1 EXO1 FAM53C FAM9B FOXO1 FOXO4 GPRIN2 HDAC5 HNRNPD ING1 KCNK15 KCNK3 KCNK9 KIAA0408 LNX2 LONRF1 MAGEA1 MAP1A MAP3K5 MARK3 MDM4 MKRN3 MST1R NFIA NFIB NFIC NR3C1 NTAQ1 PAX9 PLEKHF2 PLK4 RAB3IP RAF1 RFFL RNF126 SAMSN1 TBL3 TP53 TRIM25 TSC2 YWHAG ZC2HC1C ZFP36	61 interacting genes: ACTN2 AKT1 AKT2 AKT3 ANKRD35 BTG3 CALM1 CBY2 CCND1 CDKN1B EEF1A1 ESR1 FBXL6 FBXW5 GAPDH GRB2 GSK3B LNX1 MAPK1 MAPK3 MAPKAPK2 MDFI MKRN1 MRPL21 NEK1 PAM PHLDB1 PICK1 PIN1 PLK2 PPP1CA PPP2CA PRKAA1 PTK2 PTPN11 RAB5A RABEP1 RHEB RPL4 RPS6KA1 RPSA SEPTIN4 SERPINI1 SFN SLC13A3 SMAD2 SMAD3 SSC4D SUPT6H TK1 TRIM55 TRIM63 TSC1 UBE3A USPL1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		2810	7249
HPRD ID		03185	01850
Ensembl ID		ENSG00000175793	ENSG00000103197
Uniprot IDs		P31947	A0A2R8Y6C9 A0A2R8YDZ2 B3KWH7 H3BMQ0 P49815 Q5HYF7 X5D2U8 X5D7Q2
PDB IDs		1YWT 1YZ5 3IQJ 3IQU 3IQV 3LW1 3MHR 3O8I 3P1N 3P1O 3P1P 3P1Q 3P1R 3P1S 3SMK 3SML 3SMM 3SMN 3SMO 3SP5 3SPR 3T0L 3T0M 3U9X 3UX0 4DAT 4DAU 4DHM 4DHN 4DHO 4DHP 4DHQ 4DHR 4DHS 4DHT 4DHU 4FL5 4FR3 4IEA 4JC3 4JDD 4QLI 4Y32 4Y3B 4Y5I 5BTV 5HF3 5LTW 5LU1 5LU2 5MHC 5MOC 5MXO 5MY9 5MYC 5N5R 5N5T 5N5W 5N75 5OEG 5OEH 5OK9 5OKF 5OM0 5OMA 6FAU 6FAV 6FAW 6FBB 6FBW 6FBY 6FCP 6FI4 6FI5 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GHP 6HHP 6HKB 6HKF 6HMT 6HMU 6HN2 6NV2 6QDR 6QDS 6QDT 6QDU 6QHL 6QHM 6QIU 6QZR 6QZS 6R5L 6RHC 6RJL 6RJQ 6RJZ 6RK8 6RKI 6RKK 6RKM 6RL3 6RL4 6RL6 6RM5 6RM7 6RP6 6RWH 6RWI 6RWS 6RWU 6RX2 6S39 6S3C 6S40 6S9Q 6SIN 6SIO 6SIP 6SIQ 6SLV 6SLW 6SLX 6T5F 6T5H 6T80 6TCH 6TJM 6TL3 6TLF 6TLG 6TM7 6TWZ 6W0L 6XWD 6XXC 6XY5 6Y18 6Y1D 6Y1J 6Y3M 6Y3O 6Y3R 6Y3S 6Y3V 6Y3W 6Y40 6Y44 6Y58 6Y7T 6Y8A 6Y8B 6Y8D 6Y8E 6YE9 6YIA 6YIB 6YIC 6YLU 6YOW 6YOX 6YOY 6YP2 6YP3 6YP8 6YPL 6YPY 6YQ2 6YR5 6YR6 6YR7 6ZCJ 6ZVB 6ZVC 6ZVD 6ZVE 7AEW 7AOG 7AXN 7AYF 7AZ1 7AZ2 7B13 7B15 7B9M 7B9R 7B9T 7BA3 7BA5 7BA6 7BA7 7BA8 7BA9 7BAA 7BAB 7BDP 7BDT 7BDY 7BFW 7BG3 7BGQ 7BGR 7BGV 7BGW 7BI3 7BIQ 7BIW 7BIY 7BJB 7BJF 7BJL 7BJW 7BKH 7BM9 7BMC 7NFW 7NIF 7NIG 7NIX 7NIZ 7NJ6 7NJ8 7NJ9 7NJA 7NJB 7NK3 7NK5 7NLA 7NLE 7NM1 7NM3 7NM9 7NMA 7NMH 7NMW 7NMX 7NN2 7NND 7NNE 7NP2 7NPB 7NPG 7NQP 7NR7 7NRK 7NRL 7NSV 7NV4 7NVI 7NWS 7NXS 7NXT 7NXW 7NXY 7NY4 7NYE 7NYF 7NYG 7NZ6 7NZG 7NZK 7NZV 7O07 7O34 7O3A 7O3F 7O3P 7O3Q 7O3R 7O3S 7O57 7O59 7O5A 7O5C 7O5D 7O5F 7O5G 7O5O 7O5P 7O5S 7O5U 7O5X 7O6F 7O6G 7O6I 7O6J 7O6K 7O6M 7O6O 7OB5 7OB8 7OBC 7OBD 7OBG 7OBH 7OBK 7OBL 7OBS 7OBT 7OBX 7OBY 7OPW 7OQ7 7OQ8 7OQ9 7OQA 7OQG 7OQJ 7OQS 7OQU 7OQW 7OR3 7OR5 7OR7 7OR8 7ORG 7ORH 7ORS 7ORT 7PWT 7PWZ 7QIK 7QIP 7ZMU 7ZMW 8A62 8A65 8A68 8A6F 8A6H 8ADM 8AFN 8AI0 8ALR 8ALT 8ALV 8ALW 8AM7 8ANB 8ANC 8ANF 8AOY 8APS 8AQ1 8AQC 8AQE 8AQZ 8AR4 8AR5 8ARG 8ARO 8ARQ 8ARR 8ARW 8ARX 8ARY 8ARZ 8AS1 8AT9 8ATP 8ATR 8ATS 8AU2 8AUS 8AUY 8AV0 8AV3 8AV4 8AV7 8AV8 8AWG 8AXE 8AXU 8AZE 8B2I 8B2K 8B39 8B4Q 8B5P 8BFC 8BI7 8BJG 8BJN 8BM5 8BTQ 8BWE 8BWH 8BWJ 8BWX 8BWZ 8BX0 8BX3 8BX4 8BXI 8BXM 8BXN 8BXO 8BXQ 8BXS 8BY9 8BYB 8BYC 8BYD 8BYE 8BYF 8BYG 8BYO 8BYY 8BYZ 8BZ0 8BZ9 8BZA 8BZB 8BZC 8BZD 8BZE 8BZF 8BZG 8BZH 8BZT 8BZW 8C04 8C0K 8C0L 8C1Y 8C28 8C2D 8C2E 8C2F 8C2G 8C2Y 8C30 8C3C 8C3Z 8C40 8C42 8C43 8C4F 8C4G 8P0D 8Q4L 8Q55 8Q5C 8R0Z 8RRK 8RRL 8RRM 8S42 9AXA 9F35	7DL2 9CE3
Enriched GO Terms of Interacting Partners?		MAP Kinase Kinase Kinase Activity Regulation Of Protein Metabolic Process Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Peptidyl-serine Phosphorylation MAPK Cascade Kinase Activity Intracellular Signal Transduction Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Response To Wounding Protein Metabolic Process Cellular Response To Oxidative Stress Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Action Potential Firing Rate Apoptotic Process DNA Strand Resection Involved In Replication Fork Processing Response To Starvation Potassium Ion Leak Channel Activity Regulation Of Macromolecule Metabolic Process Programmed Cell Death Cell Death Cellular Response To Reactive Nitrogen Species Nucleus Protein Serine Kinase Activity Cellular Response To Acidic PH Positive Regulation Of RNA Metabolic Process Negative Regulation Of Protein Metabolic Process Response To Oxidative Stress Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process Cellular Response To Chemical Stress Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Starvation Positive Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of DNA-templated Transcription Response To Nutrient Levels Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Programmed Cell Death	Intracellular Signal Transduction Protein Modification Process Protein Metabolic Process Phosphoserine Residue Binding Regulation Of TOR Signaling Cytosol TOR Signaling Negative Regulation Of TOR Signaling Protein Kinase Binding Cytoplasm TORC1 Signaling Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Regulation Of Signal Transduction Protein Domain Specific Binding Macromolecule Metabolic Process Cellular Response To Stress Protein Sequestering Activity Ciliary Basal Body Identical Protein Binding Insulin Receptor Signaling Pathway Signal Transduction Protein Kinase Activity Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Kinase Activity Protein Phosphorylation Protein Serine Kinase Activity Regulation Of Synaptic Plasticity SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Stability Negative Regulation Of Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway Phosphorylation Negative Regulation Of Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Cell Communication Nucleus Regulation Of Immune Response Regulation Of Protein Metabolic Process Protein Serine/threonine Kinase Activity
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