SFN and RFWD2

Number of citations of the paper that reports this interaction (PMID 21625211)
10

Data Source:
BioGRID (enzymatic study)

		SFN	RFWD2
Gene Name		stratifin	ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome	Golgi Membrane Nucleoplasm Cytoplasm Centrosome Cytosol Focal Adhesion Nuclear Speck
	Molecular Function	Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Phosphoprotein Binding	Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Release Of Cytochrome C From Mitochondria Keratinocyte Development Negative Regulation Of Protein Kinase Activity Apoptotic Process Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Epidermal Cell Division Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Cell Growth Keratinization Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Protein Export From Nucleus Membrane Organization Establishment Of Skin Barrier Negative Regulation Of Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis	p53-Dependent G1 DNA Damage Response Autodegradation of the E3 ubiquitin ligase COP1 Stabilization of p53 Cell Cycle Checkpoints p53-Dependent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions		49 interactors: ABL1 BAD BAX BCR CCAR1 CCDC102B CCNH CDC25B CDK1 CHST1 EEF1A1 EGFR EIF2S1 EIF4B EXO1 FAM189A2 FAM53C FAM9B FOXO4 GPRIN2 HDAC5 HNRNPD ING1 KCNK15 KCNK3 KCNK9 KIAA0408 LONRF1 MAGEA1 MAP3K5 MARK3 MDM4 MKRN3 MST1R NR3C1 PLEKHF2 PLK4 RAB3IP RFFL RFWD2 SAMSN1 TBL3 TP53 TRIM25 TSC2 WDYHV1 YWHAG ZC2HC1C ZFP36	14 interactors: CCT4 DET1 ETS1 ETS2 JUN JUND PTPN1 RB1CC1 SFN SIPA1 TP53 UBE2D1 UBE2D2 YWHAZ
Entrez ID		2810	64326
HPRD ID		03185	07455
Ensembl ID		ENSG00000175793	ENSG00000143207
Uniprot IDs		P31947	Q05CT6 Q8NHY2
PDB IDs		1YWT 1YZ5 3IQJ 3IQU 3IQV 3LW1 3MHR 3O8I 3P1N 3P1O 3P1P 3P1Q 3P1R 3P1S 3SMK 3SML 3SMM 3SMN 3SMO 3SPR 3T0L 3T0M 3U9X 3UX0 4DAT 4DAU 4DHM 4DHN 4DHO 4DHP 4DHQ 4DHR 4DHS 4DHT 4DHU 4FR3 4HQW 4HRU 4IEA 4JC3 4JDD
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Neuron Death Cell Cycle Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Cellular Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Cellular Response To Organonitrogen Compound Regulation Of Phosphorus Metabolic Process Cell Cycle Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Mitotic Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction ERBB Signaling Pathway Regulation Of Protein Kinase Activity Response To Stress Mitotic Cell Cycle Positive Regulation Of Cell Cycle Response To Organic Substance Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Catalytic Activity Cellular Response To Insulin Stimulus G2/M Transition Of Mitotic Cell Cycle Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Mitochondrion Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Hormone Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of Intracellular Signal Transduction Cellular Response To Hormone Stimulus Regulation Of Cell Proliferation B Cell Activation Fc Receptor Signaling Pathway	Cellular Response To Stress Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Response To Abiotic Stimulus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stress Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Transcription From RNA Polymerase II Promoter Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Mitochondrion Organization Cellular Response To Extracellular Stimulus Regulation Of Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Apoptotic Mitochondrial Changes Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Regulation Of Mitochondrion Organization Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hypoxia Intracellular Signal Transduction Cellular Response To Decreased Oxygen Levels Response To Wounding Regulation Of Cellular Component Organization Toll-like Receptor Signaling Pathway Apoptotic Signaling Pathway Cellular Response To Oxygen Levels Cellular Response To Stimulus Mitochondrion Organization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Immune System Process Cellular Response To Starvation Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Apoptotic Process Organelle Organization RNA Metabolic Process Transcription, DNA-templated Negative Regulation Of Cell Cycle Negative Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Endoplasmic Reticulum Stress Negative Regulation Of Programmed Cell Death Response To Extracellular Stimulus
Tagcloud ?		aging alarm amplitude auditory circuits cortico elderly electrophysiologically employed false finding frontal impairments latency limbic memory n4 p3 perform position potentials prefrontal recency serial sternberg subjects task working young
Tagcloud (Difference) ?		aging alarm amplitude auditory circuits cortico elderly electrophysiologically employed false finding frontal impairments latency limbic memory n4 p3 perform position potentials prefrontal recency serial sternberg subjects task working young
Tagcloud (Intersection) ?