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POLM and IKZF3
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
POLM
IKZF3
Gene Name
polymerase (DNA directed), mu
IKAROS family zinc finger 3 (Aiolos)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Nucleus
Cytoplasm
Plasma Membrane
Molecular Function
DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Metal Ion Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Metal Ion Binding
Protein Heterodimerization Activity
Biological Process
DNA Repair
DNA Recombination
Somatic Hypermutation Of Immunoglobulin Genes
B Cell Differentiation
DNA Biosynthetic Process
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Mesoderm Development
Regulation Of B Cell Proliferation
B Cell Activation
Regulation Of Apoptotic Process
Regulation Of B Cell Differentiation
Regulation Of Lymphocyte Differentiation
Pathways
Drugs
Diseases
GWAS
Crohn's disease (
21102463
)
Inflammatory bowel disease (
23128233
)
Primary biliary cirrhosis (
19458352
23000144
20639880
)
Rheumatoid arthritis (
20453842
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Ulcerative colitis (
21297633
)
Protein-Protein Interactions
10 interactors:
CEP55
IKZF3
PCNA
PNMA1
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2H
71 interactors:
ABLIM3
AES
AKAP9
AQP1
ARMC7
ARNT2
ATPAF2
BCAS2
BCL2L1
C1orf109
CABP5
CDKN1A
CDKN2D
CHCHD2
CHD3
DGCR6
EFHC1
EMC2
EXOC8
EXOSC5
FANCL
FARS2
FBF1
GEM
GRB2
HNRNPF
HRAS
IKZF1
IKZF4
IKZF5
ING5
KAT5
KRT19
LGALS14
LMO1
LMO2
MAGOHB
MORN3
MRPL28
MRPL53
NATD1
NEK6
OAZ3
OSGIN1
PCID2
PFDN5
PIK3R2
PIN1
POLM
POLR1C
PPP1R16B
PRKAA1
PRKAB2
PSMA1
RAD51D
RBBP8
RCOR3
RHOA
SPG21
STAMBPL1
STK16
STX11
TBC1D22B
TCAF1
TEKT4
TRAPPC6A
TRIM42
TSSK3
TSTD2
UBE2I
ZGPAT
Entrez ID
27434
22806
HPRD ID
16208
05869
Ensembl ID
ENSG00000122678
Uniprot IDs
Q9NP87
Q9UKT9
PDB IDs
2DUN
2HTF
Enriched GO Terms of Interacting Partners
?
Protein K48-linked Ubiquitination
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein Catabolic Process
Protein K11-linked Ubiquitination
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Mitotic Spindle Assembly Checkpoint
Spindle Assembly Checkpoint
Cellular Macromolecule Catabolic Process
Mitotic Spindle Checkpoint
Negative Regulation Of Chromosome Segregation
Spindle Checkpoint
Regulation Of Mitotic Sister Chromatid Separation
Negative Regulation Of Mitotic Nuclear Division
Regulation Of Mitotic Metaphase/anaphase Transition
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Proteasomal Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Proteasomal Protein Catabolic Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Cellular Protein Catabolic Process
Positive Regulation Of Ligase Activity
Mitotic Cell Cycle Process
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Cell Division
Regulation Of Chromosome Segregation
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Chromosome Organization
Mitotic Cell Cycle
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Negative Regulation Of Protein Ubiquitination
Toll-like Receptor Signaling Pathway
Cell Cycle
Cell Cycle Process
Mitotic Cell Cycle Process
Organelle Organization
Gene Expression
Mitotic Cell Cycle
Negative Regulation Of Cellular Metabolic Process
Cellular Response To Stress
Cellular Response To DNA Damage Stimulus
Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Radiation
Regulation Of Cell Cycle
Positive Regulation Of Metabolic Process
Cellular Response To Organonitrogen Compound
Response To Hormone
Nucleobase-containing Compound Metabolic Process
Cell Cycle Checkpoint
RNA Metabolic Process
Response To Ionizing Radiation
Cell Cycle Arrest
Regulation Of Signal Transduction
Insulin Receptor Signaling Pathway
Response To Organic Substance
Regulation Of Transcription From RNA Polymerase II Promoter
Heterocycle Metabolic Process
Cellular Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Mitotic Cell Cycle
Immune System Process
Response To Stress
Nitrogen Compound Metabolic Process
Signal Transduction In Response To DNA Damage
Negative Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Cellular Response To Hormone Stimulus
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Gene Expression
Negative Regulation Of Cell Cycle
Cellular Macromolecule Biosynthetic Process
Transcription, DNA-templated
Regulation Of Signaling
Ammonium Transmembrane Transport
Biosynthetic Process
Macromolecule Biosynthetic Process
Neurotrophin TRK Receptor Signaling Pathway
Cellular Response To Insulin Stimulus
Cellular Response To Organic Substance
Response To Organonitrogen Compound
Tagcloud
?
17q12
amplicon
cab2
ccct
darpp32
endued
gc
han
haplotype
histogenesis
immumohistochemical
implied
per1
perld1
ppp1r1b
q21
rs11869286
rs1877031
rs881844
rs9972882
sequenom
signet
stard3
steroidogenic
tcap
titin
tma
top2a
znfn1a3
Tagcloud (Difference)
?
17q12
amplicon
cab2
ccct
darpp32
endued
gc
han
haplotype
histogenesis
immumohistochemical
implied
per1
perld1
ppp1r1b
q21
rs11869286
rs1877031
rs881844
rs9972882
sequenom
signet
stard3
steroidogenic
tcap
titin
tma
top2a
znfn1a3
Tagcloud (Intersection)
?