POLM and CEP55

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		POLM	CEP55
Description		DNA polymerase mu	centrosomal protein 55
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Cytoplasm Centrosome Centriole Cytoskeleton Membrane Midbody Cleavage Furrow Intercellular Bridge Flemming Body
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity DNA Polymerase Activity Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Somatic Hypermutation Of Immunoglobulin Genes B Cell Differentiation DNA Biosynthetic Process	Mitotic Cytokinesis Nucleus Organization Mitotic Metaphase Chromosome Alignment Establishment Of Protein Localization Cell Division Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Midbody Abscission Cranial Skeletal System Development
Pathways		Nonhomologous End-Joining (NHEJ)
Drugs
Diseases
GWAS			High density lipoprotein cholesterol levels ( 30498476) Metabolite levels ( 23823483)
Interacting Genes		14 interacting genes: CEP55 CTAG1A CTAG1B IKZF3 OGT PCNA PNMA1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H USHBP1	94 interacting genes: AIRIM AKAP9 ANXA11 ARHGEF15 BAG4 C1orf216 CBY2 CCBE1 CCDC120 CCHCR1 CDC37 CDC45 CDK1 CDSN CEP57L1 CFTR COL8A1 CPSF7 DTNB ECSIT EIF1AD ENKD1 ESS2 EXOSC5 FAM161B FAM90A1 FBF1 FXR2 GOLGA2 GOLGA8DP HAUS1 HGS HNRNPA0 HSF2BP KANK2 KIFC3 KRT31 LENG1 LGALS4 LRRC23 MAPK1 MAPK1IP1L MFAP1 MIA3 MORF4L2 NDEL1 NEDD4L NOS3 NTAQ1 NXF1 OGT PCNT PDCD6IP PEF1 PIN1 PLEKHG6 PLK1 POLM POM121 PPP1R16B PRPF6 PSEN2 PSMC2 PTPN23 PWWP3A RAB3D RBM14 RBM17 RBM22 RBM42 RBPMS RCOR3 RNF32 SDCBP SF1 SFPQ SNRPB SNRPN SNW1 SS18L1 SUPT5H TCL1A TEAD4 TEX11 TFG TFIP11 TP53BP2 TSG101 UBC VPS37C VPS37D WASHC1 WASHC3 ZNF48
Entrez ID		27434	55165
HPRD ID		16208	12569
Ensembl ID		ENSG00000122678	ENSG00000138180
Uniprot IDs		Q9NP87	Q53EZ4
PDB IDs		2DUN 2HTF 4LZD 4LZG 4M04 4M0A 4YCX 4YD1 4YD2 5TWP 5TWQ 5TWR 5TWS 5TXX 5TXZ 5TYB 5TYC 5TYD 5TYE 5TYF 5TYG 5TYU 5TYV 5TYW 5TYX 5TYY 5TYZ 5VZ7 5VZ8 5VZ9 5VZA 5VZB 5VZC 5VZD 5VZE 5VZF 5VZG 5VZH 5VZI 5W4F 5ZLC 6AEC 6AEH 6AK5 6AK6 6AK8 6AK9 6AKH 6IPD 6IPE 6IPF 6IPG 6IPH 6IPI 6IPJ 6IPK 6IPL 6IPM 6IPN 6P1M 6P1N 6P1O 6P1P 6P1Q 6P1R 6P1S 6P1T 6P1U 6P1V 6P1W 6VEZ 6VF0 6VF1 6VF2 6VF3 6VF4 6VF5 6VF6 6VF7 6VF8 6VF9 6VFA 6VFB 6VFC 6WIC 6WID 6WIE 7CO6 7CO8 7CO9 7COA 7COB 7COC 7COD 7KSS 7KST 7KSU 7KSV 7KSW 7KSX 7KSY 7KSZ 7KT0 7KT1 7KT2 7KT3 7KT4 7KT5 7KT6 7KT7 7KT8 7KT9 7KTA 7KTB 7KTC 7KTD 7KTE 7KTF 7KTG 7KTH 7KTI 7KTJ 7KTK 7KTL 7KTM 7KTN	3E1R 3WUT 3WUU 3WUV
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K11-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis Post-translational Protein Modification Macromolecule Catabolic Process TRNA Threonylcarbamoyladenosine Metabolic Process Protein Modification Process Ubiquitin Protein Ligase Activity Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Catabolic Process ATP Binding Regulation Of Protein Ubiquitination Proteasomal Protein Catabolic Process PCNA Complex Replisome Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Post-translational Protein Modification Protein Monoubiquitination Macromolecule Metabolic Process Protein Catabolic Process TORC1 Signaling Negative Regulation Of BMP Signaling Pathway PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Nucleotide Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Autoubiquitination TOR Signaling Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Regulation Of Cellular Response To Growth Factor Stimulus Protein O-acetylglucosaminyltransferase Activity Regulation Of TORC1 Signaling Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation ISG15 Transferase Activity Positive Regulation Of Exit From Mitosis Positive Regulation Of Protein Ubiquitination	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Protein Binding Spliceosomal Complex Centrosome MRNA Processing Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway RNA Splicing Nucleoplasm MRNA Metabolic Process Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Catalytic Step 2 Spliceosome Cytoskeleton Multivesicular Body Assembly Multivesicular Body Organization Positive Regulation Of Exosomal Secretion Late Endosome To Vacuole Transport Organelle Organization Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Endosome Transport Via Multivesicular Body Sorting Pathway RNA Processing Calcium-dependent Protein Binding RNA Binding Viral Budding Via Host ESCRT Complex Multivesicular Body Sorting Pathway Positive Regulation Of Exocytosis Viral Budding MRNA Binding Protein Localization To Vacuole Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Component Assembly Nucleic Acid Metabolic Process Microtubule Nucleation Cytosol Establishment Of Protein Localization To Vacuole ESCRT I Complex Centriole Cytoplasm Spindle Nucleic Acid Binding U4/U6 X U5 Tri-snRNP Complex Microtubule Cytoskeleton Organization Involved In Mitosis MRNA Cis Splicing, Via Spliceosome SnRNP Binding Endosome Organization Microtubule Organizing Center Organization Membrane Fission Microtubule-based Process Organelle Assembly
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