CSN2 and HTRA2

Number of citations of the paper that reports this interaction (PMID 10971580)
33

Data Source:
HPRD (in vitro)

		CSN2	HTRA2
Gene Name		casein beta	HtrA serine peptidase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Chromatin Nucleus Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Membrane CD40 Receptor Complex
	Molecular Function	Enzyme Inhibitor Activity Transporter Activity Calcium Ion Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Unfolded Protein Binding
	Biological Process	Calcium Ion Transport Lactation Negative Regulation Of Catalytic Activity	Proteolysis Ceramide Metabolic Process Mitochondrion Organization Adult Walking Behavior Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Herbicide Positive Regulation Of Cell Death Protein Autoprocessing Pentacyclic Triterpenoid Metabolic Process Forebrain Development Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Interferon-beta Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Catabolic Process Negative Regulation Of Cell Cycle Neuron Development Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Execution Phase Of Apoptosis Negative Regulation Of Neuron Death Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrion Degradation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Pathways		Nuclear signaling by ERBB4 Signaling by ERBB4
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: AURKA CDC42 CDK1 CELA1 CSN3 CSNK2A1 CSNK2B FHL2 GRB2 HTRA2 NEK1 NEK2 NEK8 NFYC PLK1 RAC1 TOLLIP	37 interactors: ACTA1 ALDH1A2 APC APP AREL1 BIRC2 BIRC3 BIRC6 BIRC7 CAD CCAR2 CDK1 CDK5 CSN1S1 CSN2 DIABLO EEF1A1 EIF4G1 HSD17B10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 PAG1 PDXDC1 PDXDC2P PEA15 TRIM28 TUBA1A TUBB TUBB6 TUBB7P USP7 VIM VPS4B XIAP
Entrez ID		1447	27429
HPRD ID		00281	05919
Ensembl ID		ENSG00000135222	ENSG00000115317
Uniprot IDs		P05814	O43464
PDB IDs			1LCY 2PZD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Anatomical Structure Development Mitotic Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Mitotic Nuclear Division Developmental Process Cell Projection Morphogenesis Cell Part Morphogenesis Mitotic Nuclear Division Regulation Of Organelle Organization Anatomical Structure Morphogenesis Neuron Development Neuron Projection Morphogenesis Regulation Of Cellular Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Axon Guidance Mitotic Cell Cycle Process Cell Morphogenesis Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Segregation Cell Division Neuron Differentiation Regulation Of Protein Metabolic Process Cell Projection Organization Centrosome Organization Regulation Of Cell Division Neuron Projection Development Regulation Of Binding Multicellular Organismal Development Microtubule Organizing Center Organization Positive Regulation Of Signal Transduction Wnt Signaling Pathway Cell Development Axonogenesis Protein Phosphorylation G2/M Transition Of Mitotic Cell Cycle Phosphorylation Cell Cycle Positive Regulation Of Protein Modification Process Cellular Protein Catabolic Process Regulation Of Cell Cycle Axon Development Regulation Of Metabolic Process Mitotic Nuclear Envelope Disassembly System Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Protein Stability Chemotaxis	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Proteolysis Cellular Protein Metabolic Process Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Proteolysis Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Protein Processing Regulation Of Protein Metabolic Process Protein Metabolic Process Regulation Of Protein Processing Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Toll-like Receptor Signaling Pathway Response To Stimulus Regulation Of Cell Death Cellular Response To Stimulus MAPK Cascade Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Stress Regulation Of Innate Immune Response Activation Of Innate Immune Response Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Peptidase Activity Cellular Response To Stress Cellular Protein Modification Process Signal Transduction By Phosphorylation Response To Organic Substance Cellular Response To DNA Damage Stimulus Positive Regulation Of Innate Immune Response Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Stress-activated MAPK Cascade Peptidyl-serine Phosphorylation Stress-activated Protein Kinase Signaling Cascade Neurotrophin Signaling Pathway
Tagcloud ?		0x 1x 25x 2x 4ebp1 4x 5x 8x arg arginine bovine casein conditionally csn1s csn1s1 csn1s2 csn3 devoid except excess experimental gland mammary mtor output resemble s6k stat5 true	betal concerned decreasing designed ec endometrial er estrogen heterogeneous hnrnp hnrnps ihc immunohistochemisty insight intimate investigation link nucleus performs pharmaceutical possesses prognosis real recurrence recurrent ribonucleoprotein shows towards transformer
Tagcloud (Difference) ?		0x 1x 25x 2x 4ebp1 4x 5x 8x arg arginine bovine casein conditionally csn1s csn1s1 csn1s2 csn3 devoid except excess experimental gland mammary mtor output resemble s6k stat5 true	betal concerned decreasing designed ec endometrial er estrogen heterogeneous hnrnp hnrnps ihc immunohistochemisty insight intimate investigation link nucleus performs pharmaceutical possesses prognosis real recurrence recurrent ribonucleoprotein shows towards transformer
Tagcloud (Intersection) ?