CSN2 and CELA1

Number of citations: 0 (PubMedID 9187653)
Data Source: HPRD (in vitro)

		CSN2	CELA1
Name		casein beta	chymotrypsin like elastase 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Enzyme Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Calcium Ion Transport Lactation	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Proteolysis Inflammatory Response Post-embryonic Development Wnt Signaling Pathway Exocrine Pancreas Development Multicellular Organism Growth Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Tissue Remodeling Digestive System Development Elastin Catabolic Process Pancreas Morphogenesis
Pathways		Nuclear signaling by ERBB4 Developmental Lineage of Mammary Gland Alveolar Cells	None
Drugs		None	N,N-dimethylformamide Cumidine Mdl 101,146 2-[5-Methanesulfonylamino-2-(4-Aminophenyl)-6-Oxo-1,6-Dihydro-1-Pyrimidinyl]-N-(3,3,3-Trifluoro-1-Isopropyl-2-Oxopropyl)Acetamide N-{4-[(Carboxymethyl)carbamoyl]benzoyl}-L-valyl-N-[(3S)-1,1,1-trifluoro-4-methyl-2-oxo-3-pentanyl]-L-prolinamide N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-alanyl-L-alaninamide N-[2-(1-Formyl-2-Methyl-Propyl)-1-(4-Piperidin-1-Yl-but-2-Enoyl)-Pyrrolidin-3-Yl]-Methanesulfonamide Freselestat (3R)-3-ethyl-N-[(4-methylphenyl)sulfonyl]-L-aspartic acid (TERT-BUTYLOXYCARBONYL)-ALANYL-AMINO ETHYL-FORMAMIDE (2-BROMOETHYL)(2-'FORMYL-4'-AMINOPHENYL) ACETATE [1-(3-CHLORO-2-FORMYL-PHENYLCARBAMOYL)-2-METHYL-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER METHYL(2-ACETOXY-2-(2-CARBOXY-4-AMINO-PHENYL))ACETATE (2R)-3-{[(BENZYLAMINO)CARBONYL]AMINO}-2-HYDROXYPROPANOIC ACID 3-[[(METHYLAMINO)SULFONYL]AMINO]-2-OXO-6-PHENYL-N-[3,3,3-TRIFLUORO-1-(1-METHYLETHYL)-2-OXOPHENYL]-1(2H)-PYRIDINE ACETAMIDE (2S,3S)-3-FORMYL-2-({[(4-METHYLPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID (2S,3S)-3-FORMYL-2-({[(4-NITROPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID
GWAS		No GWAS studies recorded	Neutrophil count ( 32888494 ) Obesity-related traits ( 23251661 )
Novel Interactors		None recorded	2 novel interactors: CDK2 ERBB3
Interacting Genes		18 interacting genes: AURKA CDC42 CDK1 CELA1 CSN3 CSNK2A1 CSNK2B FHL2 GRB2 HTRA2 NEK1 NEK2 NEK9 NFYC PLK1 RAC1 TOLLIP UBQLN2	6 interacting genes: A2M CSN2 LPA PI3 SERPINA1 SERPINA3
Entrez ID		1447	1990
HPRD ID		00281	00553
Ensembl ID		ENSG00000135222	ENSG00000139610
Uniprot IDs		P05814 W5RWE1	Q9UNI1
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Phosphorylation Centrosome Centrosome Separation Protein Kinase Activity Protein Phosphorylation Midbody Regulation Of Attachment Of Spindle Microtubules To Kinetochore Kinase Activity Regulation Of Proteasomal Protein Catabolic Process Protein Localization To Site Of Double-strand Break Spindle Midzone Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Cell Division Protein Kinase Binding Regulation Of Cell Cycle Regulation Of Mitotic Nuclear Division Wnt Signaling Pathway Organelle Organization Positive Regulation Of Organelle Organization Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Mitotic Cell Cycle Spindle Microtubule Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Mitotic Cell Cycle Regulation Of Nuclear Division Centrosome Cycle Signal Transduction In Response To DNA Damage Nucleotide Binding G2/M Transition Of Mitotic Cell Cycle G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Cell Cycle Cell Cycle G2/M Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Cytoskeleton Organization Ventricular Cardiac Muscle Cell Development Thioesterase Binding Regulation Of Cellular Component Organization Mitotic Nuclear Membrane Disassembly Cytoskeleton Cilium Disassembly Positive Regulation Of Protein Catabolic Process Cytosol Regulation Of Cell Cycle Process	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Endopeptidase Inhibitor Activity Extracellular Region Platelet Alpha Granule Lumen Extracellular Space Extracellular Matrix Acute-phase Response Growth Factor Binding Acute Inflammatory Response Plasma Lipoprotein Particle Negative Regulation Of Complement Activation, Lectin Pathway Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Copulation Protease Binding Interleukin-8 Binding Blood Microparticle Positive Regulation Of Chromatin Organization Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Neuregulin Receptor Activity X Chromosome ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity Tumor Necrosis Factor Binding Interleukin-1 Binding Protection From Non-homologous End Joining At Telomere Schwann Cell Differentiation Regulation Of Heterochromatin Formation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway