GLI2 and SUFU

Number of citations of the paper that reports this interaction (PMID 10564661)
29

Data Source:
HPRD (in vitro)

		GLI2	SUFU
Gene Name		GLI family zinc finger 2	suppressor of fused homolog (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Membrane Nuclear Speck Motile Primary Cilium Ciliary Tip Ciliary Base	Nucleus Nucleoplasm Cytoplasm Cytosol Primary Cilium Ciliary Tip Ciliary Base
	Molecular Function	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	Transcription Corepressor Activity Signal Transducer Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Osteoblast Differentiation In Utero Embryonic Development Kidney Development Chondrocyte Differentiation Osteoblast Development Transcription, DNA-templated Smoothened Signaling Pathway Pattern Specification Process Axon Guidance Ventral Midline Development Hindgut Morphogenesis Heart Development Cell Proliferation Regulation Of Smoothened Signaling Pathway Response To Mechanical Stimulus Epidermal Cell Differentiation Proximal/distal Pattern Formation Floor Plate Formation Spinal Cord Dorsal/ventral Patterning Ventral Spinal Cord Development Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Spinal Cord Ventral Commissure Morphogenesis Pituitary Gland Development Lung Development Mammary Gland Development Hindbrain Development Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of T Cell Differentiation In Thymus Tube Development Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Digestive Tract Development Developmental Growth Neuron Development Branching Morphogenesis Of An Epithelial Tube Notochord Regression Prostatic Bud Formation Mammary Gland Duct Morphogenesis Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cellular Response To Organic Cyclic Compound Cochlea Morphogenesis Cellular Response To Virus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Neural Tube Closure Heart Looping Regulation Of Transcription, DNA-templated Proteolysis Signal Transduction Multicellular Organismal Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Negative Regulation Of Transcription Factor Import Into Nucleus Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Skin Development Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog GLI proteins bind promoters of Hh responsive genes to promote transcription Degradation of GLI2 by the proteasome	Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Breast size ( 22747683) Erectile dysfunction and prostate cancer treatment ( 20932654)	Prostate cancer ( 23535732)
Protein-Protein Interactions		7 interactors: CREB1 FBXW11 SKI STK36 SUFU ZIC1 ZIC2	26 interactors: BTRC GLI1 GLI2 GLI3 GLIS3 HDX HMGA1 HNRNPA1 LAMTOR3 LGALS3 MID1IP1 NCOA3 PEX26 PIAS1 QPRT RBPJ RCN3 RNF19A SAP18 SETDB1 STK36 ZNF219 ZNF263 ZNF446 ZNF747 ZNF764
Entrez ID		2736	51684
HPRD ID		01312	06124
Ensembl ID		ENSG00000074047	ENSG00000107882
Uniprot IDs		P10070 Q1PSW9 Q59FV5	Q9UMX1
PDB IDs			1M1L
Enriched GO Terms of Interacting Partners?		Central Nervous System Development Brain Development Head Development Regulation Of Smoothened Signaling Pathway Neural Tube Closure Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neural Tube Formation Nervous System Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Anatomical Structure Morphogenesis Regulation Of RNA Biosynthetic Process Embryonic Epithelial Tube Formation Epithelial Tube Formation Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Tube Formation Regulation Of Protein Import Into Nucleus Morphogenesis Of Embryonic Epithelium Regulation Of Gene Expression Embryonic Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Neural Tube Development Regulation Of Protein Localization To Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nucleocytoplasmic Transport Tube Development Organ Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Signaling Regulation Of Intracellular Protein Transport Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Localization Anatomical Structure Formation Involved In Morphogenesis Epithelium Development Epithelial Tube Morphogenesis Embryo Development System Development Negative Regulation Of Protein Import Into Nucleus Tube Morphogenesis Regulation Of Intracellular Transport Negative Regulation Of Ossification	RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Smoothened Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Notochord Regression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Mammary Gland Morphogenesis Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Tube Morphogenesis Smoothened Signaling Pathway Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Ventral Midline Development Gland Development Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Organ Formation Proximal/distal Pattern Formation Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Pituitary Gland Development Gland Morphogenesis Positive Regulation Of Neural Precursor Cell Proliferation Mammary Gland Development Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation
Tagcloud ?		activates bcar4 ccl21 chemokine consequences consisting coordinated correlates enables extended h3k18ac hedgehog indirect lnas lncrna lncrnas locked noncanonical nucleic pnuts pol pp1 recruited releases relieve snip1 suppresses tumorigenic turn	beta1 blots cck colorectal constructed counting enhances gli1 hedgehog hh ht29 infecting integrin interference invasion itgb1 kit lentiviral lentivirus malignancies migrating rnai shh sonic transwell unrelated vectors xenografted xenografting
Tagcloud (Difference) ?		activates bcar4 ccl21 chemokine consequences consisting coordinated correlates enables extended h3k18ac indirect lnas lncrna lncrnas locked noncanonical nucleic pnuts pol pp1 recruited releases relieve snip1 suppresses tumorigenic turn	beta1 blots cck colorectal constructed counting enhances gli1 hh ht29 infecting integrin interference invasion itgb1 kit lentiviral lentivirus malignancies migrating rnai shh sonic transwell unrelated vectors xenografted xenografting
Tagcloud (Intersection) ?		hedgehog