GLI2 and ZIC2

Number of citations: 0 (PubMedID 11238441)
Data Source: HPRD (in vitro)

		GLI2	ZIC2
Name		GLI family zinc finger 2	Zic family zinc finger 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Cilium Ciliary Basal Body Cell Projection Ciliary Tip Ciliary Base GLI-SUFU Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation Kidney Development Osteoblast Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Pattern Specification Process Axon Guidance Ventral Midline Development Hindgut Morphogenesis Heart Development Anatomical Structure Morphogenesis Epidermal Cell Differentiation Proximal/distal Pattern Formation Regulation Of Gene Expression Floor Plate Formation Spinal Cord Dorsal/ventral Patterning Ventral Spinal Cord Development Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Spinal Cord Ventral Commissure Morphogenesis Pituitary Gland Development Lung Development Mammary Gland Development Hindbrain Development Hair Follicle Morphogenesis Positive Regulation Of T Cell Differentiation In Thymus Tube Development Odontogenesis Of Dentin-containing Tooth Positive Regulation Of DNA Replication Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Digestive Tract Development Developmental Growth Neuron Development Branching Morphogenesis Of An Epithelial Tube Cellular Response To Virus	Regulation Of Transcription By RNA Polymerase II Nervous System Development Central Nervous System Development Brain Development Visual Perception Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of DNA-binding Transcription Factor Activity
Pathways		Degradation of GLI2 by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription RUNX2 regulates chondrocyte maturation	Formation of the anterior neural plate
Diseases		Holoprosencephaly (HPE)	Holoprosencephaly (HPE)
GWAS		Acne (severe) ( 30542056 ) Age-related macular degeneration ( 23326517 ) Appendicular lean mass ( 33097823 ) Breast size ( 22747683 ) Diastolic blood pressure ( 30224653 ) Diisocyanate-induced asthma ( 25918132 ) Erectile dysfunction and prostate cancer treatment ( 20932654 ) Estimated glomerular filtration rate ( 31015462 ) Estimated glomerular filtration rate in coronary artery disease and impaired kidney function ( 30809046 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Glomerular filtration rate (creatinine) ( 26831199 ) Height ( 28552196 25429064 31562340 ) Serum alkaline phosphatase levels ( 33547301 ) Serum uric acid levels ( 30993211 ) Type 2 diabetes ( 30054458 30297969 ) Waist circumference adjusted for body mass index ( 34021172 ) Weight ( 34074324 )	Hyperopia ( 25233373 ) Myopia ( 27182965 ) Refractive error ( 23396134 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 )
Interacting Genes		13 interacting genes: AR BTRC CREB1 FBXW11 OTUB2 SKI SPOP STK36 SUFU TAF9 TSG101 ZIC1 ZIC2	3 interacting genes: GLI1 GLI2 GLI3
Entrez ID		2736	7546
HPRD ID		01312	04353
Ensembl ID		ENSG00000074047	ENSG00000043355
Uniprot IDs		A0A7I2PJA1 P10070 Q1PSW9 Q59FV5	O95409
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Smoothened Signaling Pathway Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Protein Stability Regulation Of Proteolysis Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleus Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Regulation Of Cell Communication Positive Regulation Of Nucleobase-containing Compound Metabolic Process Animal Organ Development Regulation Of Signaling Anatomical Structure Morphogenesis Beta-catenin Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Ubiquitin Protein Ligase Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Circadian Rhythm Macromolecule Metabolic Process Regulation Of Signal Transduction RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Olfactory Bulb Development Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Smoothened Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Glial Cell Proliferation Negative Regulation Of Metabolic Process Prostate Induction Transcription Coactivator Binding Negative Regulation Of Transcription By RNA Polymerase II Cellular Developmental Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding	GLI-SUFU Complex Proximal/distal Pattern Formation Ciliary Tip Ciliary Base Dorsal/ventral Pattern Formation Ventral Midline Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Hindgut Morphogenesis Lung Development Cerebellar Cortex Morphogenesis Osteoblast Differentiation Double-stranded DNA Binding Spinal Cord Dorsal/ventral Patterning Embryonic Digestive Tract Development Gland Development Regionalization Tube Morphogenesis Pituitary Gland Development RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Pattern Specification Process Mammary Gland Development Positive Regulation Of DNA Replication Sequence-specific DNA Binding Digestive Tract Development Cilium Odontogenesis Of Dentin-containing Tooth Regulation Of Smoothened Signaling Pathway Epidermal Cell Differentiation Odontogenesis Regulation Of DNA Replication Notochord Regression Axoneme Positive Regulation Of T Cell Differentiation Branching Morphogenesis Of An Epithelial Tube Lateral Semicircular Canal Development Sagittal Suture Morphogenesis Lambdoid Suture Morphogenesis Lateral Ganglionic Eminence Cell Proliferation Anterior Semicircular Canal Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Lymphocyte Differentiation Regulation Of Osteoblast Differentiation Morphogenesis Of A Branching Epithelium DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Morphogenesis Of A Branching Structure Embryonic Organ Development Kidney Development Negative Regulation Of Wnt Signaling Pathway