GLI2 and ZIC2

Number of citations of the paper that reports this interaction (PMID 11238441)
36

Data Source:
HPRD (in vitro)

		GLI2	ZIC2
Gene Name		GLI family zinc finger 2	Zic family member 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Membrane Nuclear Speck Motile Primary Cilium Ciliary Tip Ciliary Base	Nucleus Cytoplasm
	Molecular Function	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Chromatin DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Osteoblast Differentiation In Utero Embryonic Development Kidney Development Chondrocyte Differentiation Osteoblast Development Transcription, DNA-templated Smoothened Signaling Pathway Pattern Specification Process Axon Guidance Ventral Midline Development Hindgut Morphogenesis Heart Development Cell Proliferation Regulation Of Smoothened Signaling Pathway Response To Mechanical Stimulus Epidermal Cell Differentiation Proximal/distal Pattern Formation Floor Plate Formation Spinal Cord Dorsal/ventral Patterning Ventral Spinal Cord Development Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Spinal Cord Ventral Commissure Morphogenesis Pituitary Gland Development Lung Development Mammary Gland Development Hindbrain Development Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of T Cell Differentiation In Thymus Tube Development Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Digestive Tract Development Developmental Growth Neuron Development Branching Morphogenesis Of An Epithelial Tube Notochord Regression Prostatic Bud Formation Mammary Gland Duct Morphogenesis Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cellular Response To Organic Cyclic Compound Cochlea Morphogenesis Cellular Response To Virus	Neural Tube Closure Transcription, DNA-templated Brain Development Visual Perception Retinal Ganglion Cell Axon Guidance Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Developmental Pigmentation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways		Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog GLI proteins bind promoters of Hh responsive genes to promote transcription Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Breast size ( 22747683) Erectile dysfunction and prostate cancer treatment ( 20932654)	Refractive error ( 23396134)
Protein-Protein Interactions		7 interactors: CREB1 FBXW11 SKI STK36 SUFU ZIC1 ZIC2	3 interactors: GLI1 GLI2 GLI3
Entrez ID		2736	7546
HPRD ID		01312	04353
Ensembl ID		ENSG00000074047	ENSG00000043355
Uniprot IDs		P10070 Q1PSW9 Q59FV5	O95409
PDB IDs
Enriched GO Terms of Interacting Partners?		Central Nervous System Development Brain Development Head Development Regulation Of Smoothened Signaling Pathway Neural Tube Closure Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neural Tube Formation Nervous System Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Anatomical Structure Morphogenesis Regulation Of RNA Biosynthetic Process Embryonic Epithelial Tube Formation Epithelial Tube Formation Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Tube Formation Regulation Of Protein Import Into Nucleus Morphogenesis Of Embryonic Epithelium Regulation Of Gene Expression Embryonic Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Neural Tube Development Regulation Of Protein Localization To Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nucleocytoplasmic Transport Tube Development Organ Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Signaling Regulation Of Intracellular Protein Transport Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Localization Anatomical Structure Formation Involved In Morphogenesis Epithelium Development Epithelial Tube Morphogenesis Embryo Development System Development Negative Regulation Of Protein Import Into Nucleus Tube Morphogenesis Regulation Of Intracellular Transport Negative Regulation Of Ossification	Proximal/distal Pattern Formation Notochord Regression Positive Regulation Of Neural Precursor Cell Proliferation Digestive Tract Morphogenesis Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Ventral Midline Development Regulation Of Smoothened Signaling Pathway Regulation Of Neural Precursor Cell Proliferation Smoothened Signaling Pathway Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Dorsal/ventral Pattern Formation Digestive Tract Development Digestive System Development Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Hindgut Morphogenesis Notochord Morphogenesis Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Hindgut Development Ventral Spinal Cord Interneuron Specification Spinal Cord Motor Neuron Cell Fate Specification Lung Development Anatomical Structure Regression Ventral Spinal Cord Interneuron Fate Commitment Respiratory Tube Development Ventral Spinal Cord Interneuron Differentiation Respiratory System Development Notochord Development Embryonic Organ Morphogenesis Spinal Cord Dorsal/ventral Patterning Neuron Fate Specification Spinal Cord Patterning Tube Morphogenesis Dorsal/ventral Neural Tube Patterning Forebrain Development Cerebellar Cortex Morphogenesis Pattern Specification Process Embryonic Digestive Tract Development Embryonic Organ Development Gland Development Spinal Cord Motor Neuron Differentiation Organ Formation Epithelial Cell Differentiation Cerebellum Morphogenesis Hindbrain Morphogenesis Pituitary Gland Development Ventral Spinal Cord Development Neural Tube Patterning
Tagcloud ?		activates bcar4 ccl21 chemokine consequences consisting coordinated correlates enables extended h3k18ac hedgehog indirect lnas lncrna lncrnas locked noncanonical nucleic pnuts pol pp1 recruited releases relieve snip1 suppresses tumorigenic turn	alobar anteverted bitemporal c1091 consanguineous etiologically fissures frank gli2 gln364leufs holoprosencephaly hpe insipidus insufficiencies mlu mosm nares narrowing neuroanatomic osmolality osmolarity palpebral philtrum prosencephalon sonic syndromic teratogenic trh upslanting
Tagcloud (Difference) ?		activates bcar4 ccl21 chemokine consequences consisting coordinated correlates enables extended h3k18ac hedgehog indirect lnas lncrna lncrnas locked noncanonical nucleic pnuts pol pp1 recruited releases relieve snip1 suppresses tumorigenic turn	alobar anteverted bitemporal c1091 consanguineous etiologically fissures frank gln364leufs holoprosencephaly hpe insipidus insufficiencies mlu mosm nares narrowing neuroanatomic osmolality osmolarity palpebral philtrum prosencephalon sonic syndromic teratogenic trh upslanting
Tagcloud (Intersection) ?		gli2