GLI2 and FBXW11

Number of citations of the paper that reports this interaction (PMID 16651270)
27

Data Source:
HPRD (in vivo)

		GLI2	FBXW11
Gene Name		GLI family zinc finger 2	F-box and WD repeat domain containing 11
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Membrane Nuclear Speck Motile Primary Cilium Ciliary Tip Ciliary Base	Ubiquitin Ligase Complex Nucleus Centrosome Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	Ubiquitin-protein Transferase Activity Protein Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Osteoblast Differentiation In Utero Embryonic Development Kidney Development Chondrocyte Differentiation Osteoblast Development Transcription, DNA-templated Smoothened Signaling Pathway Pattern Specification Process Axon Guidance Ventral Midline Development Hindgut Morphogenesis Heart Development Cell Proliferation Regulation Of Smoothened Signaling Pathway Response To Mechanical Stimulus Epidermal Cell Differentiation Proximal/distal Pattern Formation Floor Plate Formation Spinal Cord Dorsal/ventral Patterning Ventral Spinal Cord Development Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Spinal Cord Ventral Commissure Morphogenesis Pituitary Gland Development Lung Development Mammary Gland Development Hindbrain Development Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of T Cell Differentiation In Thymus Tube Development Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Digestive Tract Development Developmental Growth Neuron Development Branching Morphogenesis Of An Epithelial Tube Notochord Regression Prostatic Bud Formation Mammary Gland Duct Morphogenesis Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cellular Response To Organic Cyclic Compound Cochlea Morphogenesis Cellular Response To Virus	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Protein Dephosphorylation Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Negative Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Rhythmic Process
Pathways		Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog GLI proteins bind promoters of Hh responsive genes to promote transcription Degradation of GLI2 by the proteasome	Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) Antigen processing: Ubiquitination & Proteasome degradation Activation of NF-kappaB in B cells G2/M Transition Class I MHC mediated antigen processing & presentation Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Adaptive Immune System
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Breast size ( 22747683) Erectile dysfunction and prostate cancer treatment ( 20932654)	Height ( 20881960 23563607)
Protein-Protein Interactions		7 interactors: CREB1 FBXW11 SKI STK36 SUFU ZIC1 ZIC2	14 interactors: AMER1 BHLHE40 BTRC CDC25A CUL1 GLI2 IFNAR1 KDR NFKB1 NFKBIA PRLR TRIM21 UBE2D3 WEE1
Entrez ID		2736	23291
HPRD ID		01312	07294
Ensembl ID		ENSG00000074047	ENSG00000072803
Uniprot IDs		P10070 Q1PSW9 Q59FV5	B4DH70 Q9UKB1
PDB IDs
Enriched GO Terms of Interacting Partners?		Central Nervous System Development Brain Development Head Development Regulation Of Smoothened Signaling Pathway Neural Tube Closure Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neural Tube Formation Nervous System Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Anatomical Structure Morphogenesis Regulation Of RNA Biosynthetic Process Embryonic Epithelial Tube Formation Epithelial Tube Formation Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Tube Formation Regulation Of Protein Import Into Nucleus Morphogenesis Of Embryonic Epithelium Regulation Of Gene Expression Embryonic Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Neural Tube Development Regulation Of Protein Localization To Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nucleocytoplasmic Transport Tube Development Organ Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Signaling Regulation Of Intracellular Protein Transport Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Localization Anatomical Structure Formation Involved In Morphogenesis Epithelium Development Epithelial Tube Morphogenesis Embryo Development System Development Negative Regulation Of Protein Import Into Nucleus Tube Morphogenesis Regulation Of Intracellular Transport Negative Regulation Of Ossification	Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Stimulus Regulation Of Type I Interferon Production Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity G2/M Transition Of Mitotic Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Monoubiquitination Response To Organic Substance Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Regulation Of Innate Immune Response Cellular Response To Stimulus Signal Transduction Positive Regulation Of Type I Interferon Production Mitotic Cell Cycle Phase Transition Toll-like Receptor 4 Signaling Pathway Cell Cycle Phase Transition Response To Abiotic Stimulus Mammary Gland Epithelium Development Signaling Rhythmic Process Negative Regulation Of RNA Biosynthetic Process Cell Communication Toll-like Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Signal Transduction Negative Regulation Of Gene Expression Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Biosynthetic Process Innate Immune Response Regulation Of Cellular Process Activation Of Innate Immune Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Immune System Process Protein Destabilization G1/S Transition Of Mitotic Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Mammary Gland Development Protein Polyubiquitination Circadian Rhythm Regulation Of Cell Cycle Cellular Protein Modification Process Positive Regulation Of Innate Immune Response
Tagcloud ?		activates bcar4 ccl21 chemokine consequences consisting coordinated correlates enables extended h3k18ac hedgehog indirect lnas lncrna lncrnas locked noncanonical nucleic pnuts pol pp1 recruited releases relieve snip1 suppresses tumorigenic turn	adapter aneuploidy betatrcp2 biochemistry comprehensively computation cul1 destabilized gef guanine identifier immunopurified instrumentation ligases multinucleation necessitates pac polyubiquitylated processivity proteomexchange proteomics putatively pxd001062 rap1 rapgef2 scf skp1 ubiquitylated ubiquitylation
Tagcloud (Difference) ?		activates bcar4 ccl21 chemokine consequences consisting coordinated correlates enables extended h3k18ac hedgehog indirect lnas lncrna lncrnas locked noncanonical nucleic pnuts pol pp1 recruited releases relieve snip1 suppresses tumorigenic turn	adapter aneuploidy betatrcp2 biochemistry comprehensively computation cul1 destabilized gef guanine identifier immunopurified instrumentation ligases multinucleation necessitates pac polyubiquitylated processivity proteomexchange proteomics putatively pxd001062 rap1 rapgef2 scf skp1 ubiquitylated ubiquitylation
Tagcloud (Intersection) ?