GLI2 and TAF9

Number of citations of the paper that reports this interaction (PubMedID 26282181)
52

Data Source:
BioGRID (pull down)

		GLI2	TAF9
Description		GLI family zinc finger 2	TATA-box binding protein associated factor 9
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Cilium Ciliary Basal Body Cell Projection Ciliary Tip Ciliary Base GLI-SUFU Complex	SAGA Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFTC Complex Pre-snoRNP Complex MLL1 Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Transcription Cis-regulatory Region Binding P53 Binding DNA Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Protein Heterodimerization Activity ATPase Binding C2H2 Zinc Finger Domain Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation Kidney Development Osteoblast Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Pattern Specification Process Axon Guidance Ventral Midline Development Hindgut Morphogenesis Heart Development Anatomical Structure Morphogenesis Epidermal Cell Differentiation Proximal/distal Pattern Formation Regulation Of Gene Expression Floor Plate Formation Spinal Cord Dorsal/ventral Patterning Ventral Spinal Cord Development Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Spinal Cord Ventral Commissure Morphogenesis Pituitary Gland Development Lung Development Mammary Gland Development Hindbrain Development Hair Follicle Morphogenesis Positive Regulation Of T Cell Differentiation In Thymus Tube Development Odontogenesis Of Dentin-containing Tooth Positive Regulation Of DNA Replication Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Digestive Tract Development Developmental Growth Neuron Development Branching Morphogenesis Of An Epithelial Tube Cellular Response To Virus	Box C/D SnoRNP Assembly Regulation Of DNA Repair Chromatin Remodeling DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		Degradation of GLI2 by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription RUNX2 regulates chondrocyte maturation	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome HATs acetylate histones RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases		Holoprosencephaly (HPE)
GWAS		Acne (severe) ( 30542056) Age-related macular degeneration ( 23326517) Appendicular lean mass ( 33097823) Breast size ( 22747683) Diastolic blood pressure ( 30224653) Diisocyanate-induced asthma ( 25918132) Erectile dysfunction and prostate cancer treatment ( 20932654) Estimated glomerular filtration rate ( 31015462) Estimated glomerular filtration rate in coronary artery disease and impaired kidney function ( 30809046) Femur bone mineral density x serum urate levels interaction ( 34046847) Glomerular filtration rate (creatinine) ( 26831199) Height ( 28552196 25429064 31562340) Serum alkaline phosphatase levels ( 33547301) Serum uric acid levels ( 30993211) Type 2 diabetes ( 30054458 30297969) Waist circumference adjusted for body mass index ( 34021172) Weight ( 34074324)
Interacting Genes		13 interacting genes: AR BTRC CREB1 FBXW11 OTUB2 SKI SPOP STK36 SUFU TAF9 TSG101 ZIC1 ZIC2	57 interacting genes: AHR ANK2 APP CEBPB CIITA COIL DRAP1 EEF1A1 ELF3 FBL FBLN1 FEZ1 GALNT6 GLI1 GLI2 GLI3 GTF2B H3-4 HCFC1 HNF4A HSF1 KLF6 KMT2A KPNA1 KPNA6 LAMTOR5 MAGEC2 MYC NCOA2 NCOR1 NDRG1 NFATC2 NR1D2 NUFIP1 PJA1 RBM48 RELA RNF138 RPS14 RPS24 RUVBL1 RUVBL2 SF3B3 TAF1 TAF10 TAF11 TAF12 TAF2 TAF4 TAF5 TAF6 TAF6L TAF7 TAF8 TBCA TP53 UBA1
Entrez ID		2736	6880
HPRD ID		01312	15983
Ensembl ID		ENSG00000074047	ENSG00000273841
Uniprot IDs		A0A7I2PJA1 P10070 Q1PSW9 Q59FV5	Q16594
PDB IDs			6F3T 6MZC 6MZD 6MZL 6MZM 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGF 7EGG 7EGI 7EGJ 7ENA 7ENC 8GXQ 8GXS 8H7G 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Smoothened Signaling Pathway Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Protein Stability Regulation Of Proteolysis Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleus Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Regulation Of Cell Communication Positive Regulation Of Nucleobase-containing Compound Metabolic Process Animal Organ Development Regulation Of Signaling Anatomical Structure Morphogenesis Beta-catenin Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Ubiquitin Protein Ligase Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Circadian Rhythm Macromolecule Metabolic Process Regulation Of Signal Transduction RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Olfactory Bulb Development Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Smoothened Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Glial Cell Proliferation Negative Regulation Of Metabolic Process Prostate Induction Transcription Coactivator Binding Negative Regulation Of Transcription By RNA Polymerase II Cellular Developmental Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding	RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFIID Complex Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Transcription Initiation At RNA Polymerase II Promoter RNA Polymerase II Preinitiation Complex Assembly Nucleoplasm Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Transcription Transcription Preinitiation Complex Assembly Positive Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Positive Regulation Of Transcription Initiation By RNA Polymerase II MRNA Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process TBP-class Protein Binding Protein-DNA Complex Assembly MLL1 Complex Nucleic Acid Metabolic Process Transcription Factor TFTC Complex Macromolecule Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA Metabolic Process Protein Heterodimerization Activity Protein-containing Complex Assembly Protein-containing Complex Organization Regulation Of Gene Expression DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA Repair
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