GLI2 and SKI

Number of citations of the paper that reports this interaction (PMID 12435627)
19

Data Source:
HPRD (two hybrid)

		GLI2	SKI
Gene Name		GLI family zinc finger 2	SKI proto-oncogene
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Membrane Nuclear Speck Motile Primary Cilium Ciliary Tip Ciliary Base	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Centrosome Nuclear Body PML Body Transcriptional Repressor Complex Protein Complex
	Molecular Function	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding SMAD Binding Histone Deacetylase Inhibitor Activity Repressing Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Osteoblast Differentiation In Utero Embryonic Development Kidney Development Chondrocyte Differentiation Osteoblast Development Transcription, DNA-templated Smoothened Signaling Pathway Pattern Specification Process Axon Guidance Ventral Midline Development Hindgut Morphogenesis Heart Development Cell Proliferation Regulation Of Smoothened Signaling Pathway Response To Mechanical Stimulus Epidermal Cell Differentiation Proximal/distal Pattern Formation Floor Plate Formation Spinal Cord Dorsal/ventral Patterning Ventral Spinal Cord Development Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Spinal Cord Ventral Commissure Morphogenesis Pituitary Gland Development Lung Development Mammary Gland Development Hindbrain Development Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of T Cell Differentiation In Thymus Tube Development Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Digestive Tract Development Developmental Growth Neuron Development Branching Morphogenesis Of An Epithelial Tube Notochord Regression Prostatic Bud Formation Mammary Gland Duct Morphogenesis Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cellular Response To Organic Cyclic Compound Cochlea Morphogenesis Cellular Response To Virus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Tube Closure Lens Morphogenesis In Camera-type Eye Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Cell Proliferation Negative Regulation Of Cell Proliferation Anterior/posterior Axis Specification Gene Expression Negative Regulation Of Schwann Cell Proliferation Myotube Differentiation Olfactory Bulb Development Myelination In Peripheral Nervous System Positive Regulation Of Wnt Signaling Pathway Embryonic Limb Morphogenesis BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Histone Deacetylation Negative Regulation Of Activin Receptor Signaling Pathway Somatic Stem Cell Maintenance Regulation Of Apoptotic Process Camera-type Eye Development Positive Regulation Of DNA Binding Nose Morphogenesis Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Fibroblast Proliferation Camera-type Eye Morphogenesis Skeletal Muscle Fiber Development Cell Motility Palate Development Retina Development In Camera-type Eye Face Morphogenesis Bone Morphogenesis SMAD Protein Signal Transduction Protein Homotrimerization
Pathways		Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog GLI proteins bind promoters of Hh responsive genes to promote transcription Degradation of GLI2 by the proteasome	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Signaling by BMP Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Breast size ( 22747683) Erectile dysfunction and prostate cancer treatment ( 20932654)
Protein-Protein Interactions		7 interactors: CREB1 FBXW11 SKI STK36 SUFU ZIC1 ZIC2	20 interactors: AKT1 GLI2 GLI3 HIPK2 JUN MECP2 MYB NCOR1 NFIX PML SIN3A SKIL SMAD1 SMAD2 SMAD3 SMAD4 SNW1 SPI1 TGFBR1 TRIM28
Entrez ID		2736	6497
HPRD ID		01312	01271
Ensembl ID		ENSG00000074047	ENSG00000157933
Uniprot IDs		P10070 Q1PSW9 Q59FV5	P12755
PDB IDs			1MR1 1SBX
Enriched GO Terms of Interacting Partners?		Central Nervous System Development Brain Development Head Development Regulation Of Smoothened Signaling Pathway Neural Tube Closure Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neural Tube Formation Nervous System Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Anatomical Structure Morphogenesis Regulation Of RNA Biosynthetic Process Embryonic Epithelial Tube Formation Epithelial Tube Formation Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Tube Formation Regulation Of Protein Import Into Nucleus Morphogenesis Of Embryonic Epithelium Regulation Of Gene Expression Embryonic Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Neural Tube Development Regulation Of Protein Localization To Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nucleocytoplasmic Transport Tube Development Organ Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Signaling Regulation Of Intracellular Protein Transport Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Localization Anatomical Structure Formation Involved In Morphogenesis Epithelium Development Epithelial Tube Morphogenesis Embryo Development System Development Negative Regulation Of Protein Import Into Nucleus Tube Morphogenesis Regulation Of Intracellular Transport Negative Regulation Of Ossification	Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cell Differentiation Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transcription, DNA-templated Organ Development RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway System Development Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process In Utero Embryonic Development Cellular Response To Growth Factor Stimulus Developmental Process Response To Growth Factor Cellular Response To Organic Substance Embryo Development Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation Response To Organic Substance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Biosynthetic Process Tissue Development Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		activates bcar4 ccl21 chemokine consequences consisting coordinated correlates enables extended h3k18ac hedgehog indirect lnas lncrna lncrnas locked noncanonical nucleic pnuts pol pp1 recruited releases relieve snip1 suppresses tumorigenic turn	behind board compression compressive conservative consider fundamental hyperflexed knee knees manufacturers nerve neuropathy nylon outrigger padding palsy participation peroneal predisposition recreational rider secured sport strap straps thighs tibia wish
Tagcloud (Difference) ?		activates bcar4 ccl21 chemokine consequences consisting coordinated correlates enables extended h3k18ac hedgehog indirect lnas lncrna lncrnas locked noncanonical nucleic pnuts pol pp1 recruited releases relieve snip1 suppresses tumorigenic turn	behind board compression compressive conservative consider fundamental hyperflexed knee knees manufacturers nerve neuropathy nylon outrigger padding palsy participation peroneal predisposition recreational rider secured sport strap straps thighs tibia wish
Tagcloud (Intersection) ?