GLI2

Name	GLI family zinc finger 2
Structure	No pdb structure
Novel Interactors	1 novel interactors: HSPD1
Interactors	13 interactors: AR BTRC CREB1 FBXW11 OTUB2 SKI SPOP STK36 SUFU TAF9 TSG101 ZIC1 ZIC2
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Cilium Ciliary Basal Body Cell Projection Ciliary Tip Ciliary Base GLI-SUFU Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation Kidney Development Osteoblast Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Pattern Specification Process Axon Guidance Ventral Midline Development Hindgut Morphogenesis Heart Development Anatomical Structure Morphogenesis Epidermal Cell Differentiation Proximal/distal Pattern Formation Regulation Of Gene Expression Floor Plate Formation Spinal Cord Dorsal/ventral Patterning Ventral Spinal Cord Development Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Spinal Cord Ventral Commissure Morphogenesis Pituitary Gland Development Lung Development Mammary Gland Development Hindbrain Development Hair Follicle Morphogenesis Positive Regulation Of T Cell Differentiation In Thymus Tube Development Odontogenesis Of Dentin-containing Tooth Positive Regulation Of DNA Replication Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Digestive Tract Development Developmental Growth Neuron Development Branching Morphogenesis Of An Epithelial Tube Cellular Response To Virus
Pathways	Degradation of GLI2 by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription RUNX2 regulates chondrocyte maturation
Diseases	Holoprosencephaly (HPE)
GWAS	Acne (severe) ( 30542056 ) Age-related macular degeneration ( 23326517 ) Appendicular lean mass ( 33097823 ) Breast size ( 22747683 ) Diastolic blood pressure ( 30224653 ) Diisocyanate-induced asthma ( 25918132 ) Erectile dysfunction and prostate cancer treatment ( 20932654 ) Estimated glomerular filtration rate ( 31015462 ) Estimated glomerular filtration rate in coronary artery disease and impaired kidney function ( 30809046 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Glomerular filtration rate (creatinine) ( 26831199 ) Height ( 28552196 25429064 31562340 ) Serum alkaline phosphatase levels ( 33547301 ) Serum uric acid levels ( 30993211 ) Type 2 diabetes ( 30054458 30297969 ) Waist circumference adjusted for body mass index ( 34021172 ) Weight ( 34074324 )
Entrez ID	2736
HPRD ID	01312
Ensembl ID	ENSG00000074047
Uniprot IDs	A0A7I2PJA1 P10070 Q1PSW9 Q59FV5
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Smoothened Signaling Pathway Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Protein Stability Regulation Of Proteolysis Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleus Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Regulation Of Cell Communication Positive Regulation Of Nucleobase-containing Compound Metabolic Process Animal Organ Development Regulation Of Signaling Anatomical Structure Morphogenesis Beta-catenin Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Ubiquitin Protein Ligase Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Circadian Rhythm Macromolecule Metabolic Process Regulation Of Signal Transduction RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Olfactory Bulb Development Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Smoothened Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Glial Cell Proliferation Negative Regulation Of Metabolic Process Prostate Induction Transcription Coactivator Binding Negative Regulation Of Transcription By RNA Polymerase II Cellular Developmental Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding