FEM1B and KIAA0319

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		FEM1B	KIAA0319
Gene Name		fem-1 homolog b (C. elegans)	KIAA0319
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Early Endosome Plasma Membrane Integral Component Of Membrane Early Endosome Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Death Receptor Binding Protein Binding	Protein Binding
	Biological Process	Apoptotic Process Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of DNA Damage Checkpoint	Neuron Migration Negative Regulation Of Dendrite Development
Pathways
Drugs
Diseases
GWAS		Major depressive disorder ( 23377640)	Radiation response ( 20923822)
Protein-Protein Interactions		8 interactors: APAF1 FAS GLI1 HIF1AN KIAA0319 NKX3-1 PPM1F RAD9A	2 interactors: FEM1B SH2B1
Entrez ID		10116	9856
HPRD ID		16889	18713
Ensembl ID			ENSG00000137261
Uniprot IDs		Q9UK73	Q5VV43
PDB IDs			2E7M
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Endopeptidase Activity Zymogen Activation Cellular Response To Oxygen Levels Regulation Of Peptidase Activity Positive Regulation Of Signal Transduction Regulation Of Proteolysis Regulation Of Apoptotic Process Protein Processing Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Drug Neuron Apoptotic Process Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Programmed Cell Death Neuron Death Positive Regulation Of Hydrolase Activity Positive Regulation Of Response To DNA Damage Stimulus Cell Death Death Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Tube Morphogenesis Peptidyl-histidine Hydroxylation Response To G1 DNA Damage Checkpoint Signaling Peptidyl-asparagine Hydroxylation Positive Regulation Of Protein Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Metabolic Process Peptidyl-aspartic Acid Hydroxylation Motor Neuron Apoptotic Process Positive Regulation Of Androgen Secretion Cellular Response To Stimulus Regulation Of Response To DNA Damage Stimulus	Epithelial Cell Maturation Involved In Prostate Gland Development Regulation Of Cell Cycle Process Regulation Of DNA Damage Checkpoint Epithelial Cell Differentiation Involved In Prostate Gland Development Regulation Of Cell Cycle Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Maturation Regulation Of Cell Cycle Checkpoint Prostate Gland Epithelium Morphogenesis Positive Regulation Of Mitotic Nuclear Division Prostate Gland Morphogenesis Regulation Of DNA Biosynthetic Process Lamellipodium Assembly Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Lamellipodium Organization Prostate Gland Development Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud ?			6p acetylated alleles arrays chip contributing covering dcdc2 differential disabilities encompassed haplotype histones indicates intron kb located mapped markers narrowing opposite pointing rd rds reading region strongest tiling vmp
Tagcloud (Difference) ?			6p acetylated alleles arrays chip contributing covering dcdc2 differential disabilities encompassed haplotype histones indicates intron kb located mapped markers narrowing opposite pointing rd rds reading region strongest tiling vmp
Tagcloud (Intersection) ?