FEM1B and RAD9A

Number of citations of the paper that reports this interaction (PubMedID 19330022)
0

Data Source:
BioGRID (pull down)

		FEM1B	RAD9A
Description		fem-1 homolog B	RAD9 checkpoint clamp component A
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cul2-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Checkpoint Clamp Complex
	Molecular Function	Death Receptor Binding Protein Binding Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nuclease Activity Exonuclease Activity Protein Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity SH3 Domain Binding Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding
	Biological Process	Epithelial Cell Maturation Apoptotic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of DNA Damage Checkpoint	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Ionizing Radiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		Neddylation	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Major depressive disorder ( 23377640) Systolic blood pressure ( 26969751)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		9 interacting genes: APAF1 CDK5R1 FAS GLI1 KIAA0319 NKX3-1 PPM1F RAD9A SMCR8	39 interacting genes: ABL1 AR ATAD5 ATM BCL2 BCL2L1 CAD CDK1 CHEK2 CLSPN COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEM1B FEN1 HDAC1 HUS1 HUS1B ITSN2 MLH1 MSH2 MSH3 MSH6 NR3C1 OGG1 PCNA POLB PRKCE RAD17 RAD9B RHNO1 RPA1 RPA2 SF3B3 TDG TLK1 TOPBP1 WRN
Entrez ID		10116	5883
HPRD ID		16889	04788
Ensembl ID		ENSG00000169018	ENSG00000172613
Uniprot IDs		Q9UK73	Q99638
PDB IDs		6LBF 7CNG 7EL6 8IJ1 8JE1 8JE2 8WQA 8WQB 8WQC 8WQD 8WQE 8WQF 8WQG 8WQH 8WQI	3A1J 3G65 3GGR 6HM5 6J8Y 7Z6H 8GNN 8JZY 8WU8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Prostate Gland Development Regulation Of Apoptotic Signaling Pathway Signal Transduction Response To G1 DNA Damage Checkpoint Signaling Notochord Regression Positive Regulation Of Androgen Secretion MADS Box Domain Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Xenobiotic Stimulus Regulation Of Apoptotic Process Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Response To Oxygen Levels Apoptotic Process Dorsal Aorta Development Superior Olivary Nucleus Maturation Negative Regulation Of Axon Extension Involved In Regeneration Cell Death Programmed Cell Death Apoptosome Neuron Apoptotic Process Fas Signaling Pathway Ventral Midline Development Protein Kinase 5 Complex Protein Kinase Binding GLI-SUFU Complex Salivary Gland Development Cellular Response To Hyperoxia Negative Regulation Of Canonical Wnt Signaling Pathway Cerebellar Cortex Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Positive Regulation Of Intracellular Signal Transduction Histone Deacetylase Binding Checkpoint Clamp Complex Positive Regulation Of Organelle Organization G1 To G0 Transition Involved In Cell Differentiation Calmodulin-dependent Protein Phosphatase Activity Regulation Of Cellular Response To Stress Neuron Migration Regulation Of Intracellular Signal Transduction	DNA Damage Response DNA Repair DNA Metabolic Process Cellular Response To Stress Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling DNA Recombination Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Nucleic Acid Metabolic Process Mitotic DNA Integrity Checkpoint Signaling Mismatch Repair Response To Stress Regulation Of Cell Cycle Process Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Chromosome Organization Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Macromolecule Metabolic Process Nucleoplasm Intracellular Signal Transduction Response To Ionizing Radiation Response To Radiation Damaged DNA Binding Nucleus Regulation Of DNA Metabolic Process Protein Localization To Site Of Double-strand Break Recombinational Repair Mitotic Intra-S DNA Damage Checkpoint Signaling Base-excision Repair Enzyme Binding Regulation Of Mitotic Cell Cycle DNA Replication Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Stress Chromosome, Telomeric Region Somatic Cell DNA Recombination Mitotic DNA Replication Checkpoint Signaling Negative Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Negative Regulation Of DNA Recombination Mismatched DNA Binding Regulation Of DNA Recombination Guanine/thymine Mispair Binding Mitotic G2/M Transition Checkpoint
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?