FEM1B and FAS

Number of citations of the paper that reports this interaction (PubMedID 10542291)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		FEM1B	FAS
Description		fem-1 homolog B	Fas cell surface death receptor
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cul2-RING Ubiquitin Ligase Complex	Extracellular Region Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Nuclear Body Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Extracellular Exosome
	Molecular Function	Death Receptor Binding Protein Binding Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Transmembrane Signaling Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Calmodulin Binding Kinase Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	Epithelial Cell Maturation Apoptotic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of DNA Damage Checkpoint	Apoptotic Process Activation-induced Cell Death Of T Cells Immune Response Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Stress-activated MAPK Cascade Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amino Acid Starvation Fas Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Protein-containing Complex Assembly Cellular Response To Mechanical Stimulus Cellular Response To Hyperoxia Motor Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Neddylation	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 FasL/ CD95L signaling
Drugs
Diseases			Esophageal cancer Chronic lymphocytic leukemia (CLL) Hodgkin lymphoma Adult T-cell leukemia
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Major depressive disorder ( 23377640) Systolic blood pressure ( 26969751)	Ankylosing spondylitis ( 30946743) Atrioventricular conduction ( 21041692) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Chronic lymphocytic leukemia ( 23770605 24292274 26956414 28165464) Immunoglobulin A ( 20694011) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758)
Interacting Genes		9 interacting genes: APAF1 CDK5R1 FAS GLI1 KIAA0319 NKX3-1 PPM1F RAD9A SMCR8	50 interacting genes: ANK3 APAF1 APOA5 ATP6V0B BAG6 BTK CALM1 CASP8 CASP8AP2 CCND3 CD47 CRMP1 DAXX DNAJC5 EEF1A1 EGFR ERG28 EZR FADD FAF1 FAF2 FAIM2 FASLG FBF1 FEM1B FYN GADD45A HIPK3 HNRNPC LCK LRIF1 MBD4 MET PDCD6 PRKCA PTPN13 PTPN6 RAP1A RIPK1 SUMO1 TCAP TMX1 TNFSF13 TRADD TRAF3 TRIP6 UBA7 UBAC1 UBE2I UBQLN1
Entrez ID		10116	355
HPRD ID		16889	00609
Ensembl ID		ENSG00000169018	ENSG00000026103
Uniprot IDs		Q9UK73	A0A8Q3SIR6 K9J972 P25445 Q59FU8
PDB IDs		6LBF 7CNG 7EL6 8IJ1 8JE1 8JE2 8WQA 8WQB 8WQC 8WQD 8WQE 8WQF 8WQG 8WQH 8WQI	1DDF 2NA7 3EWT 3EZQ 3THM 3TJE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Prostate Gland Development Regulation Of Apoptotic Signaling Pathway Signal Transduction Response To G1 DNA Damage Checkpoint Signaling Notochord Regression Positive Regulation Of Androgen Secretion MADS Box Domain Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Xenobiotic Stimulus Regulation Of Apoptotic Process Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Response To Oxygen Levels Apoptotic Process Dorsal Aorta Development Superior Olivary Nucleus Maturation Negative Regulation Of Axon Extension Involved In Regeneration Cell Death Programmed Cell Death Apoptosome Neuron Apoptotic Process Fas Signaling Pathway Ventral Midline Development Protein Kinase 5 Complex Protein Kinase Binding GLI-SUFU Complex Salivary Gland Development Cellular Response To Hyperoxia Negative Regulation Of Canonical Wnt Signaling Pathway Cerebellar Cortex Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Positive Regulation Of Intracellular Signal Transduction Histone Deacetylase Binding Checkpoint Clamp Complex Positive Regulation Of Organelle Organization G1 To G0 Transition Involved In Cell Differentiation Calmodulin-dependent Protein Phosphatase Activity Regulation Of Cellular Response To Stress Neuron Migration Regulation Of Intracellular Signal Transduction	Cell Death Regulation Of Programmed Cell Death Apoptotic Process Programmed Cell Death Regulation Of Apoptotic Process Apoptotic Signaling Pathway Death Receptor Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Death-inducing Signaling Complex Regulation Of Protein Metabolic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cytosol Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Tumor Necrosis Factor Receptor Binding Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Macrophage Differentiation Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Ripoptosome CD95 Death-inducing Signaling Complex Positive Regulation Of Intracellular Signal Transduction Kinase Binding Regulation Of Macrophage Differentiation Regulation Of Primary Metabolic Process Negative Regulation Of Transporter Activity Identical Protein Binding Regulation Of Protein Catabolic Process Positive Regulation Of Signaling Response To Mechanical Stimulus Necroptotic Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Protein Tyrosine Kinase Activity Regulation Of Multicellular Organismal Process Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Protein-macromolecule Adaptor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Phospholipase Activator Activity
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