FEM1B

Description		fem-1 homolog B
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Death Receptor Binding Protein Binding Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Epithelial Cell Maturation Apoptotic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of DNA Damage Checkpoint
Pathways		Neddylation
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Major depressive disorder ( 23377640) Systolic blood pressure ( 26969751)
Novel Interacting Genes		1 novel interacting genes: TLE3
Interacting Genes		9 interacting genes: APAF1 CDK5R1 FAS GLI1 KIAA0319 NKX3-1 PPM1F RAD9A SMCR8
Entrez ID		10116
HPRD ID		16889
Ensembl ID		ENSG00000169018
Uniprot IDs		Q9UK73
PDB IDs		6LBF 7CNG 7EL6 8IJ1 8JE1 8JE2 8WQA 8WQB 8WQC 8WQD 8WQE 8WQF 8WQG 8WQH 8WQI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Prostate Gland Development Regulation Of Apoptotic Signaling Pathway Signal Transduction Response To G1 DNA Damage Checkpoint Signaling Notochord Regression Positive Regulation Of Androgen Secretion MADS Box Domain Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Xenobiotic Stimulus Regulation Of Apoptotic Process Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Response To Oxygen Levels Apoptotic Process Dorsal Aorta Development Superior Olivary Nucleus Maturation Negative Regulation Of Axon Extension Involved In Regeneration Cell Death Programmed Cell Death Apoptosome Neuron Apoptotic Process Fas Signaling Pathway Ventral Midline Development Protein Kinase 5 Complex Protein Kinase Binding GLI-SUFU Complex Salivary Gland Development Cellular Response To Hyperoxia Negative Regulation Of Canonical Wnt Signaling Pathway Cerebellar Cortex Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Positive Regulation Of Intracellular Signal Transduction Histone Deacetylase Binding Checkpoint Clamp Complex Positive Regulation Of Organelle Organization G1 To G0 Transition Involved In Cell Differentiation Calmodulin-dependent Protein Phosphatase Activity Regulation Of Cellular Response To Stress Neuron Migration Regulation Of Intracellular Signal Transduction
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