FEM1B and PPM1F

Number of citations of the paper that reports this interaction (PMID 11559703)
13

Data Source:
BioGRID (affinity chromatography technology, pull down)

		FEM1B	PPM1F
Gene Name		fem-1 homolog b (C. elegans)	protein phosphatase, Mg2+/Mn2+ dependent, 1F
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Cytosol Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Death Receptor Binding Protein Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding
	Biological Process	Apoptotic Process Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of DNA Damage Checkpoint	Negative Regulation Of Protein Kinase Activity Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Histone Dephosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Drug Peptidyl-threonine Dephosphorylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Growth Positive Regulation Of Chemotaxis Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Major depressive disorder ( 23377640)	Attention deficit hyperactivity disorder ( 18839057)
Protein-Protein Interactions		8 interactors: APAF1 FAS GLI1 HIF1AN KIAA0319 NKX3-1 PPM1F RAD9A	8 interactors: ARHGEF7 CAMK2A CAMK2G FAM161A FEM1A FEM1B MARS PAK1
Entrez ID		10116	9647
HPRD ID		16889	10163
Ensembl ID			ENSG00000100034
Uniprot IDs		Q9UK73	B7Z2C3 P49593
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Endopeptidase Activity Zymogen Activation Cellular Response To Oxygen Levels Regulation Of Peptidase Activity Positive Regulation Of Signal Transduction Regulation Of Proteolysis Regulation Of Apoptotic Process Protein Processing Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Drug Neuron Apoptotic Process Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Programmed Cell Death Neuron Death Positive Regulation Of Hydrolase Activity Positive Regulation Of Response To DNA Damage Stimulus Cell Death Death Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Tube Morphogenesis Peptidyl-histidine Hydroxylation Response To G1 DNA Damage Checkpoint Signaling Peptidyl-asparagine Hydroxylation Positive Regulation Of Protein Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Metabolic Process Peptidyl-aspartic Acid Hydroxylation Motor Neuron Apoptotic Process Positive Regulation Of Androgen Secretion Cellular Response To Stimulus Regulation Of Response To DNA Damage Stimulus	Protein Autophosphorylation Regulation Of Cellular Response To Heat Apoptotic Process Programmed Cell Death Cellular Response To Heat Cell Death Death Regulation Of Ubiquitin-protein Transferase Activity Ephrin Receptor Signaling Pathway Response To Heat Methionyl-tRNA Aminoacylation Cellular Protein Metabolic Process Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Lamellipodium Morphogenesis Cellular Response To Interferon-gamma G1/S Transition Of Mitotic Cell Cycle Response To Interferon-gamma Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Epithelial Cell Maturation Involved In Prostate Gland Development Response To Temperature Stimulus Regulation Of Calcium Ion Transport Cellular Protein Modification Process Innate Immune Response Regulation Of Protein Ubiquitination Cellular Response To Organic Substance Cell Projection Morphogenesis Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Lamellipodium Morphogenesis Regulation Of Relaxation Of Cardiac Muscle Histone H3-T11 Phosphorylation Cell Part Morphogenesis Morphogenesis Of A Branching Epithelium Regulation Of Relaxation Of Muscle Protein Metabolic Process Morphogenesis Of A Branching Structure Regulation Of Skeletal Muscle Adaptation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Immune System Process Contact Inhibition Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Fibroblast Migration Cell Projection Assembly Regulation Of DNA Damage Checkpoint Cell Morphogenesis Response To Abiotic Stimulus Calcium Ion Transport Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Catalytic Activity Cell Projection Organization
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