RNF11 and GGA3

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		RNF11	GGA3
Description		ring finger protein 11	golgi associated, gamma adaptin ear containing, ARF binding protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Endosome Early Endosome Recycling Endosome Extracellular Exosome	Lysosome Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Membrane Early Endosome Membrane Protein-containing Complex Recycling Endosome Recycling Endosome Membrane
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding Protein-containing Complex Binding Protein Transporter Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination	Protein Targeting To Lysosome Intracellular Protein Transport Golgi To Plasma Membrane Transport Protein Transport Vesicle-mediated Transport Protein Catabolic Process Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Positive Regulation Of Protein Catabolic Process Protein Localization To Lysosome Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Lysosomal Protein Catabolic Process
Pathways			TBC/RABGAPs MET receptor recycling Amyloid fiber formation
Drugs
Diseases
GWAS		Atrial fibrillation ( 29290336) Male-pattern baldness ( 28196072) QRS duration ( 21076409)
Interacting Genes		69 interacting genes: AKT1 ANKRD13A ANKRD28 APP ASCC2 AUP1 CALCOCO2 CBLB CCDC127 DCUN1D1 EPN1 EPN2 EPN3 EPS15 ERCC6 FANCL GGA1 GGA2 GGA3 HERC1 HERC2 HUWE1 IKBKG ITCH MYO6 NEDD4 NEDD4L OPTN PDCD6IP POLI PTPRC QARS1 RABGEF1 RIPK1 RNF168 RNF216 RPS27A SDCBP SMURF1 SMURF2 SNRNP70 SPRTN STAM2 STAMBP TAX1BP1 TNFAIP3 TNIP1 TOM1L2 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBQLN2 UBQLN4 USP5 WWP1 WWP2 YAP1 ZFYVE16 ZFYVE9 ZNF350	45 interacting genes: ADRA2A ADRA2B AFTPH AP1G1 AP1S2 ARAP3 ARF1 ARF3 CDKN2A CLINT1 CLTC CYTH2 DAZAP2 EGFR ETS1 GGA1 GGA2 GTPBP4 IGF2R LITAF LRP10 M6PR NPM1 P4HA3 PACS1 PLEKHB2 PTGDR PTGDS RABEP1 RNF11 RNF214 RPS27A STAB1 SYNRG TBC1D3 TOLLIP TP53 TRAPPC6A TRIM23 TSG101 UBC UPRT VPS11 VPS18 ZNF497
Entrez ID		26994	23163
HPRD ID		09955	10443
Ensembl ID		ENSG00000123091	ENSG00000125447
Uniprot IDs		Q9Y3C5	A8K6M0 B7Z456 Q9NZ52
PDB IDs			1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Macromolecule Catabolic Process Protein Polyubiquitination Proteolysis Ubiquitin Binding Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Metabolic Process Ubiquitin Protein Ligase Activity Cytosol Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Protein Monoubiquitination Endosome Ubiquitin Ligase Complex Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Negative Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Protein K63-linked Ubiquitination Positive Regulation Of Protein Catabolic Process K63-linked Polyubiquitin Modification-dependent Protein Binding Transferase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Negative Regulation Of Canonical NF-kappaB Signal Transduction Early Endosome Membrane Positive Regulation Of Protein Modification Process Autophagosome Protein-containing Complex Positive Regulation Of Post-translational Protein Modification DNA Damage Response Regulation Of Protein Ubiquitination Cytoplasm Cellular Response To Stress Extracellular Exosome	Vesicle-mediated Transport Intracellular Protein Transport Cellular Localization Clathrin-coated Vesicle Endosome Establishment Of Localization In Cell Intracellular Transport Protein Transport Establishment Of Protein Localization Endosome Membrane Intracellular Protein Localization Early Endosome Golgi Apparatus AP-1 Adaptor Complex Endocytosis Trans-Golgi Network Membrane Trans-Golgi Network Lysosomal Transport Early Endosome Membrane Perinuclear Region Of Cytoplasm Import Into Cell Vacuolar Transport Autophagy Ubiquitin Protein Ligase Binding Endosome To Lysosome Transport Alpha2-adrenergic Receptor Activity Protein-containing Complex Golgi Membrane Protein Localization To Organelle Clathrin-coated Endocytic Vesicle Membrane Endocytic Vesicle Clathrin-coated Pit Disordered Domain Specific Binding Lysosomal Membrane Late Endosome Endomembrane System Negative Regulation Of Epinephrine Secretion Golgi Vesicle Transport Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Clathrin Coat Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Clathrin Coat Of Trans-Golgi Network Vesicle CORVET Complex Ubiquitin Binding Post-Golgi Vesicle-mediated Transport Vesicle Organization Protein Localization To Ciliary Membrane Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Activity
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