RNF11 and TNIP1

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		RNF11	TNIP1
Description		ring finger protein 11	TNFAIP3 interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Endosome Early Endosome Recycling Endosome Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Identical Protein Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination	MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Translation Defense Response Inflammatory Response Leukocyte Cell-cell Adhesion Glycoprotein Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Regulation Of Primary Metabolic Process Positive Regulation Of Protein Deubiquitination
Pathways			Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Atrial fibrillation ( 29290336) Male-pattern baldness ( 28196072) QRS duration ( 21076409)	Amyotrophic lateral sclerosis ( 29566793) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Cutaneous psoriasis ( 26626624) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 23128233 28067908) Inflammatory skin disease ( 25574825) LDL cholesterol levels in HIV infection ( 33109212) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Myasthenia gravis ( 23055271) Neutrophil percentage of granulocytes ( 27863252) Psoriasis ( 25903422 25854761 25574825 23143594 19169254) Psoriasis vulgaris ( 26626624 29031612) Psoriatic arthritis ( 26626624) Rheumatoid arthritis ( 30572963) Rheumatoid arthritis (ACPA-positive) ( 23143596) Serum alkaline phosphatase levels ( 33547301) Sjögren's syndrome ( 24097067) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469 27399966 26606652 26502338 23273568 19838195 33272962 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 29293537 30572963 31672989 21750679) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		69 interacting genes: AKT1 ANKRD13A ANKRD28 APP ASCC2 AUP1 CALCOCO2 CBLB CCDC127 DCUN1D1 EPN1 EPN2 EPN3 EPS15 ERCC6 FANCL GGA1 GGA2 GGA3 HERC1 HERC2 HUWE1 IKBKG ITCH MYO6 NEDD4 NEDD4L OPTN PDCD6IP POLI PTPRC QARS1 RABGEF1 RIPK1 RNF168 RNF216 RPS27A SDCBP SMURF1 SMURF2 SNRNP70 SPRTN STAM2 STAMBP TAX1BP1 TNFAIP3 TNIP1 TOM1L2 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBQLN2 UBQLN4 USP5 WWP1 WWP2 YAP1 ZFYVE16 ZFYVE9 ZNF350	88 interacting genes: ABHD17A ADH6 AP1M1 BYSL C8orf33 CCDC112 CCDC121 CCNG1 CDC23 CDC37 CDIP1 CDKN1A CFAP53 CYSRT1 DAZAP2 DPPA4 EFEMP1 EHHADH ELOA FAM161A FAM168A GABARAP GABARAPL1 GABARAPL2 GIT2 GTF2B GTF2H1 IKBKG KIFC3 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LENG8 LITAF MAGEB18 MAGEH1 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K1 MAPK1 MAPK10 MCM10 MCRS1 MOB1B MOB3C MORF4L1 MORF4L2 NIFK NME7 NOD2 PIBF1 PNKP RABAC1 RALBP1 RARA RARG RBFOX1 RNF11 RNF8 RPL5 S100B SELPLG SHTN1 SNIP1 SPATA2 SUMO2 SYT6 TBK1 TCEA2 TCEANC TCEANC2 TNFAIP3 TNIP3 TTC39A TTF2 TXLNA TYRO3 UBC VPS33B WTAP ZBTB25 ZMAT2 ZNHIT1
Entrez ID		26994	10318
HPRD ID		09955	09216
Ensembl ID		ENSG00000123091	ENSG00000145901
Uniprot IDs		Q9Y3C5	A0A0A0MRZ4 A8K4N4 B7Z8K2 Q15025
PDB IDs			7EAL 7EAO 7EB9 8YFK 8YFL 8YFM 8YFN 9D34
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Macromolecule Catabolic Process Protein Polyubiquitination Proteolysis Ubiquitin Binding Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Metabolic Process Ubiquitin Protein Ligase Activity Cytosol Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Protein Monoubiquitination Endosome Ubiquitin Ligase Complex Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Negative Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Protein K63-linked Ubiquitination Positive Regulation Of Protein Catabolic Process K63-linked Polyubiquitin Modification-dependent Protein Binding Transferase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Negative Regulation Of Canonical NF-kappaB Signal Transduction Early Endosome Membrane Positive Regulation Of Protein Modification Process Autophagosome Protein-containing Complex Positive Regulation Of Post-translational Protein Modification DNA Damage Response Regulation Of Protein Ubiquitination Cytoplasm Cellular Response To Stress Extracellular Exosome	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Autophagosome Maturation Protein Binding Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome Cellular Response To Starvation Cellular Response To Nutrient Levels Autophagosome Assembly Protein-containing Complex Disassembly Autophagosome Organization Response To Starvation Macroautophagy Intermediate Filament Cytoplasmic Side Of Late Endosome Membrane Response To Nutrient Levels Phospholipid Binding Nucleoplasm Organelle Assembly Positive Regulation Of DNA Repair GABA Receptor Binding Regulation Of Protein Modification Process Positive Regulation Of DNA Metabolic Process Cellular Response To Stress Nucleic Acid Metabolic Process Trachea Cartilage Development Autophagy Negative Regulation Of Canonical NF-kappaB Signal Transduction Face Development Glandular Epithelial Cell Development Regulation Of Canonical NF-kappaB Signal Transduction Vacuole Organization DNA-templated Transcription Intestinal Stem Cell Homeostasis Regulation Of Cellular Response To Stress Cytosol Protein Modification Process Negative Regulation Of Cartilage Development Nucleus Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Damage Response Regulation Of Protein Phosphorylation Ciliary Basal Body Beta-tubulin Binding
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