CDC37 and RPS15A

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CDC37	RPS15A
Gene Name		cell division cycle 37	ribosomal protein S15a
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Ruffle Membrane Protein Complex Extracellular Vesicular Exosome	Cytoplasm Cytosol Membrane Cytosolic Small Ribosomal Subunit Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Kinase Binding Heat Shock Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Kinase B Binding Unfolded Protein Binding Chaperone Binding Hsp90 Protein Binding	RNA Binding Structural Constituent Of Ribosome Poly(A) RNA Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Folding Protein Targeting Protein Stabilization Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Positive Regulation Of Cell Proliferation Response To Virus Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process Positive Regulation Of Cell Cycle
Pathways		Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Constitutive Signaling by EGFRvIII	Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)
Protein-Protein Interactions		72 interactors: A2M APOE APP AR BTBD10 C19orf44 CC2D1A CDC37L1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CHGA CHUK CKS1B CKS2 CRYM CSNK2A1 CSNK2A2 CYP2C9 DCTN1 DEAF1 ECSIT EIF2AK1 ELAVL3 EXOSC1 FBXL12 FBXW4 GCDH GCH1 HSP90AA1 IFIT3 IFIT5 IKBKB IKBKE IKBKG IMMT LONP1 LOXL4 LUC7L2 MAP3K14 MAP3K3 MGEA5 MTOR MZT2B NCOA5 NOS3 NR2C2 PPHLN1 PRAM1 PRDX2 PRMT1 PSME1 RAD23A RNF32 RPS15A SAFB SNX5 SPTBN4 SQSTM1 SRC STAMBPL1 STIP1 STK11 TBK1 UBE2I ZNF205 ZNF235 ZNF266 ZNF667	6 interactors: CALM1 CDC37 DDX39B ELF5 EWSR1 VHL
Entrez ID		11140	6210
HPRD ID		05456	04723
Ensembl ID		ENSG00000105401	ENSG00000134419
Uniprot IDs		Q16543	B2R4W8 P62244
PDB IDs		1US7 2K5B 2W0G	3J3A
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Response To Stress Cellular Metabolic Process Response To External Stimulus Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Kinase Activity I-kappaB Kinase/NF-kappaB Signaling Response To Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Mitotic Cell Cycle Phase Transition Response To Virus Cell Cycle Phase Transition Catabolic Process Regulation Of Catalytic Activity Intracellular Receptor Signaling Pathway Cell Cycle Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Phosphate-containing Compound Metabolic Process Cellular Protein Modification Process Cell Cycle Process Regulation Of Signal Transduction Protein Catabolic Process Mitotic Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Signaling Toll-like Receptor 3 Signaling Pathway Regulation Of Signaling Positive Regulation Of Signal Transduction Cellular Response To Stimulus	Protein Stabilization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Stability RNA Secondary Structure Unwinding Negative Regulation Of DNA Damage Checkpoint Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Cellular Metabolic Process Viral MRNA Export From Host Cell Nucleus Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of DNA Damage Checkpoint Detection Of Calcium Ion Positive Regulation Of Transcription, DNA-templated Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Gene Expression Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Metabolic Process Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Posttranscriptional Regulation Of Gene Expression Regulation Of Interferon-gamma-mediated Signaling Pathway Polysaccharide Catabolic Process Regulation Of Response To Interferon-gamma Positive Regulation Of Monooxygenase Activity Mammary Gland Epithelial Cell Differentiation Regulation Of Cell Cycle Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Metabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Ectoderm Development Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Tagcloud ?		base chick clusters conforms consensus copies emphasize exons finger flanking gctat ggg glycosaminoglycans homeodomain hsp90 introns kilobases mzf1 pair presumptive promotion reorganization repetitive s8 sizes sp1 stabilization striking tatgggga	4e 4f accounts brassica cdc33 cdc33ts4 cerevisiae clone drosophila eif grow multicopy name napus oogenesis phenomenon produces rescuing ribosomal saccharomyces shuttle stabilization suppressing temperature termed unaffected unrelated yeast
Tagcloud (Difference) ?		base chick clusters conforms consensus copies emphasize exons finger flanking gctat ggg glycosaminoglycans homeodomain hsp90 introns kilobases mzf1 pair presumptive promotion reorganization repetitive s8 sizes sp1 striking tatgggga	4e 4f accounts brassica cdc33 cdc33ts4 cerevisiae clone drosophila eif grow multicopy name napus oogenesis phenomenon produces rescuing ribosomal saccharomyces shuttle suppressing temperature termed unaffected unrelated yeast
Tagcloud (Intersection) ?		stabilization