CDC37 and EIF2AK1

Number of citations of the paper that reports this interaction (PubMedID 11036079)
0

Data Source:
HPRD (in vitro, in vivo)

		CDC37	EIF2AK1
Description		cell division cycle 37, HSP90 cochaperone	eukaryotic translation initiation factor 2 alpha kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome Protein Folding Chaperone Complex HSP90-CDC37 Chaperone Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Kinase Regulator Activity Kinase Binding Protein Kinase Binding Heat Shock Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding Hsp90 Protein Binding Scaffold Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Heme Binding Protein Homodimerization Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Folding Protein Targeting Post-transcriptional Regulation Of Gene Expression Protein Stabilization Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type 2 Mitophagy	Mitophagy Acute Inflammatory Response Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Phagocytosis Response To Stress Negative Regulation Of Cell Population Proliferation Negative Regulation Of Translation Macrophage Differentiation Negative Regulation Of Translational Initiation By Iron Protoporphyrinogen IX Metabolic Process Protein Autophosphorylation Regulation Of Hemoglobin Biosynthetic Process Negative Regulation Of Hemoglobin Biosynthetic Process Establishment Of Localization In Cell Multicellular Organismal-level Iron Ion Homeostasis Protein Localization To Mitochondrion Integrated Stress Response Signaling HRI-mediated Signaling Positive Regulation Of Mitophagy Response To Iron Ion Starvation
Pathways		Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Constitutive Signaling by EGFRvIII Regulation of necroptotic cell death Downregulation of ERBB2 signaling RHOBTB2 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants	Response of EIF2AK1 (HRI) to heme deficiency Cellular response to mitochondrial stress
Drugs			Fostamatinib
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) LDL cholesterol levels in HIV infection ( 33109212) Multiple sclerosis ( 21833088) White blood cell count ( 32888494)	High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		182 interacting genes: A2M ACTB ACTG1 AKT1 AMOTL2 APOE APP AR BEND7 BLZF1 BTBD10 BTBD3 C19orf44 CAMK2A CAMK2B CAMK2G CARD10 CARD9 CAVIN1 CBY2 CC2D1A CCDC138 CCDC152 CCDC91 CCHCR1 CDC37L1 CDK2 CDK3 CDK4 CDK5 CDK6 CEP55 CEP70 CGGBP1 CHGA CHUK CKS1B CKS2 CRYM CSNK2A1 CSNK2A2 CT45A1 CTAG1A CTAG1B CUTC CYP2C9 DCTN1 DEAF1 DISC1 DRC4 ECSIT EIF2AK1 EIF2S1 ELAVL3 ENOX2 EXOSC1 FAM118A FAM9B FATE1 FBXL12 FBXW4 GABARAP GABARAPL1 GABARAPL2 GAS7 GCDH GCH1 GFAP GMCL1 GOLGA2 GOLGA6L9 GPRASP3 GRAMD2B GRIPAP1 HIVEP1 HOMER3 HSF2BP HSP90AA1 IFIT5 IKBKB IKBKE IKBKG IKZF3 IMMT JRK KATNBL1 KCTD13 KCTD9 KIFC3 KLHL2 KRT75 KRT76 LMNB2 LONP1 LOXL4 LUC7L2 LZTS1 MAD1L1 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K14 MAP3K3 MDFI MID1 MIPOL1 MRPL9 MTOR MZT2B NCOA5 NECAB1 NECAB2 NOS3 NR2C2 NRIP3 NT5C1A OGA OGT PAICS PDE9A PIBF1 PNMA2 POU6F2 PPHLN1 PPP5C PRAM1 PRDX2 PRKAR1B PRMT1 PRMT5 PRPH PRR20A PRR20B PRR20C PRR20D PRR20E PSMC6 PSME1 PTGES3 RABGEF1 RAD23A RAF1 REEP6 RNF32 ROPN1 RPS15A SAFB SEPTIN3 SNX5 SPTBN4 SQSTM1 SRRM4 SSNA1 STAMBPL1 STIP1 STK11 STX1A SYCE2 SYCP3 TBK1 TCF4 THAP1 THAP7 TNFAIP1 TNIP1 TRAF2 TRAF3 TRAF5 TRIM54 UBE2I USHBP1 WAC ZBED1 ZBTB26 ZBTB8A ZNF205 ZNF235 ZNF266 ZNF276 ZNF655 ZNF667 ZNF837	5 interacting genes: CDC37 EIF2S1 HSP90AA1 LCOR LIG4
Entrez ID		11140	27102
HPRD ID		05456	10684
Ensembl ID		ENSG00000105401	ENSG00000086232
Uniprot IDs		Q16543	Q9BQI3
PDB IDs		1US7 2K5B 2N5X 2NCA 2W0G 5FWK 5FWL 5FWM 5FWP 5HPE 7Z37 7Z38 7ZR0 7ZR5 7ZR6 8GAE 8GFT 8U1L
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Cytosol Protein Binding Cytoplasm Cellular Response To Nitrogen Starvation Mitophagy Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Serine/threonine Kinase Activity Phosphatidylethanolamine Binding Autophagy Of Mitochondrion Protein Serine Kinase Activity Regulation Of Canonical NF-kappaB Signal Transduction Organelle Organization Macroautophagy Positive Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of Signal Transduction CD40 Receptor Complex Protein Kinase Activity Regulation Of Proteolysis Regulation Of Intracellular Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Membrane Cyclin-dependent Protein Kinase Holoenzyme Complex IkappaB Kinase Complex Negative Regulation Of Translational Initiation Microtubule Binding Autophagy Regulation Of Protein Localization To Cell Periphery Regulation Of Signal Transduction Intracellular Protein Localization IkappaB Kinase Activity Regulation Of Signaling Regulation Of Cell Communication Serine/threonine Protein Kinase Complex Regulation Of Protein Catabolic Process Kinase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Synaptic Transmission Cellular Response To Nutrient Levels Cellular Response To Starvation Response To Starvation Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Anoikis Positive Regulation Of TORC1 Signaling Tau Protein Binding Regulation Of Macroautophagy	Ubiquitin-specific Protease Binding ER-nucleus Signaling Pathway Protein Folding Chaperone Complex Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Endoplasmic Reticulum Unfolded Protein Response Response To Heat Translation Initiation Ternary Complex Cellular Response To Heat DNA Biosynthetic Process Unfolded Protein Binding CTP Binding DATP Binding Regulation Of Nitric Oxide Metabolic Process Neurofibrillary Tangle Assembly Positive Regulation Of Chromosome Organization UTP Binding Scaffold Protein Binding Sulfonylurea Receptor Binding Establishment Of Integrated Proviral Latency Establishment Of Viral Latency HSP90-CDC37 Chaperone Complex Derlin-1-VIMP Complex Response To Manganese-induced Endoplasmic Reticulum Stress Glial Limiting End-foot Cellular Response To Stress Rho GDP-dissociation Inhibitor Binding Histone Deacetylase Binding DNA Ligase (ATP) Activity DNA Ligase IV Complex DNA Ligase Activity Response To Temperature Stimulus Response To Kainic Acid Eukaryotic Translation Initiation Factor 2 Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination DN2 Thymocyte Differentiation Cellular Response To Radiation Cellular Response To Metal Ion Negative Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Sperm Mitochondrial Sheath Protein Folding Regulation Of Defense Response Telomerase Holoenzyme Complex Assembly Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Cellular Response To Oxidative Stress HRI-mediated Signaling Response To Endoplasmic Reticulum Stress
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